Short CV/Education and training

  • 1986
    Scientific Baccalaureate, Mention Bien

  • 1989
    University of Geneva, Faculty of Sciences, B. Sc.

  • 1990
    University of Geneva, Faculty of Sciences, M. Sc.

  • 1994
    Ph.D. Mention Très Bien. Thesis director: Prof. Philippe Halban. Louis Jeantet Research Laboratory, Faculty of Medicine, University of Geneva

  • 1995 – 1998
    Post-doctoral projects with Prof. Stylianos Antonarakis, Division of Medical Genetics, Faculty of Medicine, University of Geneva

    1: development of a gene therapy protocol in a Factor VIII knock-out mouse model for Hemophilia A.

    2: molecular basis of Combined Factor V-Factor VIII deficiency.

  • Since 2008
    Associate Professor, Department of Genetic Medicine and Development, Faculty of Medicine, University of Geneva

Selected publications

  • Fish RJ and Neerman-Arbez M. A novel regulatory element between the human FGA and FGG genes. Thromb Haemost. 2012 Sep 4;108(3):427-34.

  • Fish RJ and Neerman-Arbez M. Fibrinogen gene regulation. Thromb Haemost. 2012 Sep 4;108(3):419-26.

  • Fish RJ et al. Developmental expression and organisation of fibrinogen genes in the zebrafish. Thromb Haemost. 2012 Jan;107(1):158-66.

  • Fort A et al. A liver enhancer in the fibrinogen gene cluster. Blood. 2011 Jan 6;117(1):276-82.

  • Fort A et al. Regulation of fibrinogen production by microRNAs. Blood. 2010 Oct 7;116(14):2608-15.

  • de Moerloose et al. Fibrinogen and the risk of thrombosis. Semin Thromb Hemost. 2010 Feb;36(1):7-17.

  • de Moerloose P and Neerman-Arbez M. Congenital fibrinogen disorders. Semin Thromb Hemost. 2009 Jun;35(4):356-66.

  • Neerman-Arbez M and de Moerloose P. Mutations in the fibrinogen gene cluster accounting for congenital afibrinogenemia: an update and report of 10 novel mutations. Hum Mutat. 2007 Jun;28(6):540-53.

  • Neerman-Arbez et al. Mutations in the fibrinogen Aalpha gene account for the majority of cases of congenital afibrinogenemia. Blood. 2000 Jul 1;96(1):149-52.

  • Neerman-Arbez et al. Deletion of the fibrinogen alpha-chain gene (FGA) causes congenital afibrinogenemia. J Clin Invest. 1999 Jan;103(2):215-8.



Complete list of publications

Selected projects

  • The discovery of novel mechanisms determining fibrinogen levels in the circulation is clinically relevant since a high fibrinogen level is an independent risk factor for cardiovascular disease.

  • We recently demonstrated that microRNAs (miRNAs) contribute to fibrinogen production, by direct and indirect effects on fibrinogen mRNA levels. We are now manipulating miRNA levels in several model systems followed by transcriptome analysis using RNAseq and functional validation of miRNA targets.

  • We have also identified novel enhancer elements in the fibrinogen gene cluster and are currently investigating whether variation in these newly identified genomic sequences can affect hepatic fibrinogen production and cardiovascular disease risk.

Membership in scientific bodies/juries

  • European Society of Human Genetics

  • International Society of Thrombosis and Haemostasis

  • International Fibrinogen Research Society

  • Member Forum for Genetic Research, a Platform of the Swiss Academy of Life Sciences, 2007 – 2010

Media coverage

Websites:

Soft Skills/Other activities and achievements

Additional interests

  • Board membership


Soft Skills

  • Enthusiastic and charismatic speaker

  • Communication to the lay public


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