Short CV/Education and training

  • 1996
    Doctorate, Freie Universität (FU) Berlin, Germany

  • 1996 – 1998
    Postdoctoral fellowship, Harvard Medical School, Boston, MA, USA

  • 1999
    Diplomate in clinical molecular genetics, American Board of Medical Genetics

  • Since 2002
    Head of a clinical research group at the Department of Child and Adolescent Medicine, Dresden University of Technology, Germany

  • 2002
    Specialist in human genetics

  • 2008
    Habilitation (postdoctoral qualification), Dresden University of Technology

  • Since 2010
    Head of the German Research Foundation (DFG) Clinical Research Unit KFO 249

  • Since 2012
    Professor for Molecular Paediatrics

Selected publications

  • Yan N, Regalado-Magdos AD, Stiggelbout B, Lee-Kirsch MA, Lieberman J (2010) The cytosolic exonuclease TREX1 inhibits the innate immune response to HIV-1. Nat Immunol (Epub 2010 Sept 26)

  • Ramantani G, Niggemann P, Bast T, Lee-Kirsch MA (2010) Reconciling neuroimaging and clinical findings in Aicardi-Goutières syndrome: an autoimmune-mediated encephalopathy. Am J Neuroradiol 31(7): E62-3

  • Ramantani G, Kohlhase J, Hertzberg C, Innes AM, Engel K, Hunger S, Borozdin W, Mah JK, Ungerath K, Walkenhorst H, Richardt HH, Buckard J, Bevot A, Siegel C, von Stülpnagel C, Ikonomidou C, Thomas K, Proud V, Niemann F, Wieczorek D, Häusler M, Niggemann P, Baltaci V, Conrad K, Lebon P, Lee-Kirsch MA (2010) Expanding the phenotypic spectrum of lupus erythematosus in Aicardi-Goutières syndrome. Arthritis Rheumat 62: 1469-77

  • Günther C, Meurer M, Stein A, Viehweg A, Lee-Kirsch MA (2009) Familial chilblain lupus – a monogenic form of cutaneous lupus erythematosus due to a heterozygous mutation in TREX1. Dermatology 219(2): 162-6

  • Esparza-Gordillo J, Weidinger S, Fölster-Holst R, Bauerfeind A, Ruschendorf F, Patone G, Rohde K, Marenholz I, Schulz F, Kerscher T, Hubner N, Wahn U, Schreiber S, Franke A, Vogler R, Heath S, Baurecht H, Novak N, Rodriguez E, Illig T, Lee-Kirsch MA, Ciechanowicz A, Kurek M, Piskackova T, Macek M, Lee YA, Ruether A (2009) A common variant on chromosome 11q13 is associated with atopic dermatitis. Nat Genet 41: 596-601

  • Lee-Kirsch MA, Gong M, Chowdhury D, Senenko L, Engel K, Lee Y, De Silva U, Bailey S, Witte T, Vyse TJ, Kere J, Pfeiffer S, Harvey S, Wong A, Koskenmies S, Hummel O, Rohde K, Schmidt RE, Dominiczak AF, Gahr M, Hollis T, Perrino FW, Lieberman J, Hubner N (2007) Mutations in the 3´-5´ DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nat Genet 39: 1065-1067

  • Lee-Kirsch MA, Chowdhury D, Harvey S, Gong M, Senenko L, Engel K, Pfeiffer C, Hollis T, Gahr M, Perrino FW, Lieberman J, Hubner N (2007) A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus. J Mol Med 85: 531-537

  • Lee-Kirsch MA, M. Gong, H. Schulz, F. Ruschendorf, A. Stein, C. Pfeiffer, A. Ballarini, M. Gahr, N. Hubner, and M. Linne (2006) Familial chilblain lupus, a monogenic form of cutaneous lupus erythematosus, maps to chromosome 3p. Am J Hum Genet 79: 731-737

  • Biller-Andorno N, Jakovljevic AK, Landfester K, Lee-Kirsch MA (eds) (2005) Karriere und Kind: Erfahrungsberichte von Wissenschaftlerinnen. Campus Verlag, Frankfurt, New York

Membership in scientific bodies/juries

  • Faculty, Dresden International Graduate School for Biomedicine and Bioengineering, 2011

  • National Action League for People with Rare Diseases (NAMSE), 2010


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