Short CV/Education and training

  • 1993
    BS Pharmacy at San Pablo-CEU University, Madrid, Spain

  • 1993 – 2002
    Graduate Fellow, Spanish National Cancer Center, CNIO, Spain; supervisors Drs. Mariano Barbacid & Marcos Malumbres

  • 2002
    PhD in Molecular Biology at Autónoma University, Madrid, Spain

  • 2003 – 2008
    Postdoctoral Fellow, Memorial Sloan Kettering Cancer Center, New York, USA; supervisor Dr. Robert Benezra

  • 2008 – 2010
    Research Associate, Memorial Sloan Kettering Cancer Center, New York, USA; supervisor Dr. Robert Benezra

  • 2010
    Staff Scientist, European Molecular Biology Laboratory, EMBL-Monterotondo

  • 2011
    ERC Investigator

  • 2012
    HHMI International Early Career Scientist

Selected publications

  • Schvartzman JM, Duijf PH, Sotillo R, Coker C, Benezra R. Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition. (2011) Cancer Cell 19, 701-14.

  • Sotillo R, Schvartzman JM, Socci ND, Benezra R. Mad2-induced chromosome instability leads to lung tumor relapse after oncogene withdrawal. (2010) Nature 464, 436-440.

  • Schvartzman JM*, Sotillo R* and Benezra R. Chromosomal Instability and Cancer: Mouse Modeling Through a Human Lens. (2010) Nature Reviews Cancer 10, 102-115. (*equal contribution).

  • Sotillo R, Schvartzman JM and Benezra R. Very CIN-ful: Whole chromosome instability and tumor suppressor loss-of-heterozygosity. (2009) Cancer Cell 16, 451-452.

  • Diaz-Rodriguez E*, Sotillo R*, Schvartzman JM, Benezra R. Hec1 overexpression hyperactivates the spindle assembly checkpoint and induces multiorgan tumor formation in vivo. (2008) Proceedings of the National Academy of Sciences 105, 16719?16724. (*equal contribution).

  • Sotillo R, Hernando E, Diaz-Rodriguez E, Teruya-Feldstein J, Cordon-Cardo C, Lowe SW, Benezra R. Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. (2007) Cancer Cell 1, 9-23.

  • Sotillo R, Renner O, Dubus P, Ruiz-Cabello J, Martín-Caballero J, Barbacid M, Carnero A, Malumbres M. Cooperation Between Cdk4 and p27Kip1 in Tumor Development: a Preclinical Model to Evaluate Cell Cycle Inhibitors with Therapeutic Activity. (2005) Cancer Research 65, 3846-3852.

  • Malumbres M, Sotillo R, Santamaría D, Galan J, Cerezo A, Ortega S, Dubus P, Barbacid M. Mammalian Cells Cycle without the D-Type Cyclin-Dependent Kinases Cdk4 and Cdk6. (2004) Cell 118, 1-20.

  • Ortega S, Prieto I, Odajima J, Martin A, Dubus P, Sotillo R, Barbero JL, Malumbres M, Barbacid M. Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. (2003) Nature Genetics 35, 25-31.

  • Martin J, Hunt SL, Dubus P, Sotillo R, Nehme-Pelluard F, Magnuson MA, Parlow AF, Malumbres M, Ortega S, Barbacid M. Genetic rescue of Cdk4 null mice restores pancreatic ß-cell proliferation but not homeostatic cell number. (2003) Oncogene 22, 5261-5269.

  • Sotillo R, Dubus P, Martin J, de la Cueva E, Ortega S, Malumbres M, Barbacid M. Wide spectrum of tumors in knock in mice carrying a Cdk4 protein insensitive to INK4 inhibitors. (2001) EMBO J. 20, 6637-6647.

  • Sotillo R, Garcia JF, Ortega S, Martin J, Dubus P, Barbacid M, Malumbres M. Invasive melanoma in Cdk4-targeted mice. (2001) Proceedings of the National Academy of Sciences 98, 13312-13317.

  • Latres E, Malumbres M, Sotillo R, Martin J, Ortega S, Martin-Caballero J, Flores JM, Cordon- Cardo C, Barbacid M. Limited overlapping roles of P15 (INK4b) and P18 (INK4c) cell cycle inhibitors in proliferation and tumorigenesis. (2000) EMBO J. 19, 3496-3506.


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