Short CV/Education and training

  • 1993
    M.Sc.Biomedical Sciences (Leiden University)

  • 1993 – 1998
    Ph.D in Immunology (Dept of Clinical Viro-Immunology, University of Amsterdam, van Lier Lab)

  • 1999 – 2001
    Fellow of the Dutch Cancer Society (Biochemistry Institute, University of Lausanne, Switzerland, Tschopp Lab)

  • 2001 – 2005
    Post-doc (Netherlands Cancer Institute, Amsterdam, Medema Lab)

  • 2005 – 2006
    Assistant Professor (Dept. of Medical Oncology, UMC Utrecht)

  • 2006 – 2013
    Associate Professor (Dept. of Medical Oncology, UMC Utrecht)

  • Since 2013
    Professor of Genomic Instability (Dept. of Medical Oncology, UMC Utrecht)

Selected publications

  • Van der Waal MS, Saurin AT, Vromans MJ, Vleugel M, Wurzenberger C, Gerlich DW, Medema RH, Kops GJ, Lens SM. Mps1 promotes rapid centromere accumulation of Aurora B. EMBO Rep. 13: 847 (2012).

  • Van der Waal MS, Hengeveld RC, van der Horst A, Lens SM. Cell division control by the Chromosomal Passenger Complex. Exp Cell Res. 318: 1407 (2012).

  • Hengeveld RC, Hertz NT, Vromans MJ, Zhang C, Burlingame AL, Shokat KM, Lens SM. Development of a chemical genetic approach for human Aurora B kinase identifies novel substrates of the chromosomal passenger complex. Mol. Cell. Proteomics 11: 47 (2012).

  • Wang F, Ulyanova NP, van der Waal MS, Patnaik D, Lens SM, Higgins JMG. A positive feedback loop involving Haspin and Aurora B promotes CPC accumulation at centromeres in mitosis. Current Biology 21: 1061 (2011).

  • Saurin AT, van der Waal MS, Medema RH, Lens SM, Kops GJ. Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis. Nature Communications 2: 316 (2011)

  • DeLuca KF, Lens SM, DeLuca JG. Temporal changes in Hec1 phosphorylation control kinetochore-microtubule attachment stability in mitosis. J. Cell Science 124: 622 (2011).

  • Lens SM*, Voest EE, Medema RH*. Shared and separate functions of Polo-like and Aurora kinases in cancer. Nature Reviews Cancer 10: 825 (2010).*corresponding authors

  • Vader G and Lens SM. Chromosome Segregation: Taking the Passenger Seat. Dispatch, Current Biology 20: R879-81 (2010).

  • Maia AF, Feijao T, Vromans MJM, Sunkel CE and Lens SM. Aurora B kinase cooperates with CENP-E to promote timely anaphase onset. Chromosoma 119: 405 (2010).

  • Liu D, Vader G, Vromans MJ, Lampson MA*, Lens SM*. Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates. Science 323:1350-53 (2009). *Equal contribution.

Complete list of publications

Selected projects

  • A striking feature of nearly all tumors is aneuploidy. Along the road from normal to tumor cell, cells lose or gain whole chromosomes (chromosomal instability, CIN) resulting in an aneuploid genome of the tumor. Whether CIN is cause or consequence of the cancer has for long been a matter of debate, but evidence is accumulating that it can indeed support tumorigenesis. My lab studies how chromosomal stability is normally ensured and aims to identify factors that control the chromosome segregation process, since they are key to comprehend why cancer cells become chromosomally unstable and will allow the selection of new targets that could selectively kill aneuploid tumor cells.

Membership in scientific bodies/juries

  • Netherlands Organization for Scientific Research: panel member "Mosaic" programme

  • Organizer of the EMBO Workshop on Chromosome Segregation & Aneuploidy 2013 (Breukelen, The Netherlands)

  • Member of the Executive Board of the Graduate School of Life Sciences Utrecht University


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