Short CV/Education and training

  • 1987
    Abitur (A-levels), Gymnasium (grammar school), Cologne, Germany

  • 1988 – 1995
    Studied medicine at the University of Cologne; Harvard Medical School, Boston, USA; University of California, San Francisco, USA; University of Arizona, Phoenix, USA; University College Dublin, Ireland

  • 1995
    United States Medical Licensing Examinations I & II

  • 1995 – 1996
    Foundation year at the University Children's Hospital, Heidelberg, Germany

  • 1996 – 1997
    Postdoc at the German Cancer Research Centre (DKFZ)

  • 1997 – 2001
    Junior doctor at the University Children's Hospitals of Heidelberg and Ulm, Germany

  • 1998
    Postdoc at Institute Gustave Roussy, Villejuif, France

  • 2001
    Specialist examination in paediatrics

  • 2001
    Habilitation (postdoctoral qualification) and venia legendi (authorisation to teach) in the field of paediatrics in the Faculty of Medicine, Ulm University

  • 2002 – 2007
    Heisenberg Fellowship from the German Research Foundation (DFG)

  • 2007 – 2010
    DFG W3 research professorship in paediatrics research, Ulm University

  • Since 2010
    W3 professorship and director of the Institute of Experimental Tumour Research in Paediatrics, Goethe University Frankfurt, Germany

Selected publications

  • Fulda, S. et al.: Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo. In: Nat. Med. 8, 2002, pages 808-815.

  • Vogler, M. et al.: Small molecule XIAP inhibitors enhance TRAIL-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma. In: Cancer Res. 69, 2009, pages 2425-2434.

  • Fakler, M. et al.: Small molecule XIAP inhibitors prime childhood acute leukemia cells for TRAIL-induced apoptosis and overcome Bcl-2-mediated resistance. In: Blood 113, 2009, pages 1710-1722.

  • Loeder, S. et al.: A novel paradigm to trigger apoptosis in chronic lymphocytic leukaemia. In: Cancer Res. 69, 2009, pages 8977-8986.

  • Zibat A.: Activation of the hedgehog pathway confers a poor prognosis in embryonal and fusion gene negative alveolar rhabdomyosarcoma. In: Oncogene 29, 2010, pages 6323-30.

  • Haag, C. et al.: Identification of c-FLIPL and c-FLIPS as critical regulators of death receptor-induced apoptosis in pancreatic cancer cells. In: Gut 60, 2011, pages 225-37.

  • Häcker S.: Histone deacetylase inhibitors prime medulloblastoma cells for chemotherapy-induced apoptosis by enhancing p53-dependent Bax activation. In: Oncogene 30, 2011, pages 2275-2281.

  • Bender A.: PI3K inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic Bcl-2 proteins and enhanced mitochondrial apoptosis. In: Oncogene 30, 2011, pages 494-503.

  • Unterkircher T.: Bortezomib primes glioblastoma including glioblastoma stem cells for TRAIL by increasing tBid stability and mitochondrial apoptosis. In: Clin Cancer Res 17, 2011, pages 4019-30.

  • Naumann I.: Bortezomib primes neuroblastoma cells for TRAIL-induced apoptosis by linking the death receptor to the mitochondrial pathway. In: Clin Cancer Res 17, 2011, pages 3204-18.

  • Opel D.: Targeting aberrant PI3K/Akt activation by PI103 restores sensitivity to TRAIL-induced apoptosis in neuroblastoma. In: Clin Cancer Res 17, 2011, pages 3233-47.

  • Jennewein C.: Identification of a novel pro-apoptotic role of NF-kB in the regulation of TRAIL- and CD95-mediated apoptosis of glioblastoma cells. In: Oncogene, 2011 Aug 8. [Epub ahead of print].

  • Bangert A. et al.: Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP. In: Oncogene, 2011. In print.

  • Loeder S. et al.: RIP is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis. In: Leukemia, 2011. In print.

  • Fulda S. et al.: Targeting IAP proteins for therapeutic intervention in cancer. In: Nat Rev Drug Discov 2011. In print.


Selected projects

  • Director of the EU Seventh Framework Programme (FP7) project: Systems biology of apoptosis in cancer and AIDS

  • Director of EU project IAP6/18: Signal transduction in inflammation: from gene to organism

  • Director of the BMBF (German Federal Ministry of Education and Research) project: TranSaRNet – Translational sarcoma network

  • Director of German Research Foundation (DFG) Clinical Research Unit 167: Regulation of apoptosis and its dysfunction in human diseases, since 2006

  • Director of the Marie Curie Research Training Network: ApopTrain (European Commission, Sixth Framework Programme – FP6), since 2006

  • Director of the BMBF network: Apoptosis as a target in tumour therapy, within the framework of the funding programme "Innovative therapies on a molecular and cellular basis", since 2006

Membership in scientific bodies/juries

Memberships:

  • Advisory board of the German Society for Paediatric Oncology and Haematology

  • Board of directors, International Cell Death Society

  • Executive committee, APO-SYS Consortium (EU Seventh Framework Programme – FP7)

  • Scientific advisory board, LOEWE Oncogenic Signal Transduction priority programme

  • Advisory board of the Catalan Agency for Health Technology Assessment and Research, Barcelona, Spain

  • Advisory board of the Canceropole du Grand-Est, France

  • Advisory board of the Associazione Italiana per la Ricerca sul Cancro (AIRC), Italy

  • Selection committee, executive committee of the German National Academic Foundation

  • Deputy chairperson of the Ingrid zu Solms Foundation

  • Fellowship from the Ingrid zu Solms Foundation

  • Liaison between the German National Academic Foundation and students at Goethe University Frankfurt, Germany

Editorial boards:

  • Cancer Research, Cancer Letters, Anti-Cancer Drugs, Drug Resistance Updates, Genes & Cancer, International Journal of Oncology, Molecular and Cellular Pharmacology, Open Cancer Journal, Recent Patents on Anti-Cancer Drug Discovery, American Journal of Translational Research

Additional qualifications

  • "Leadership and Responsibility" professional development certificate from the Württemberg Management and Business Academy, 2007

  • Coaching as a Leadership Role: professional development seminar, 2007

  • Baden-Württemberg certificate of higher-education pedagogy (200 hours of instruction), 2005


Contact

You can only see the contact information of the academics in the database if you are a registered user of AcademiaNet.
Please register here

Testimonials

  1. Read what our members say about AcademiaNet.

No more excuses!

  1. Please download the brochure "No more excuses" and read more about female experts in Europe, and about AcademiaNet.

Similar profiles

  1. Prof. Patrizia Agostinis

    Biology, Human medicine, Cell Biology, Cellular signaling, Cancer biology, Cancer therapy

  2. Dr. Irene Agyepong

    Human medicine, Humanmedizin, Public Health, Public Health, Public Health

  3. Prof. Dr. Heike Allgayer

    Biology, Human medicine

  4. Prof. Caroline Ann Austin

    Biology, Chemistry, Human medicine, Molecular Biology and Cell Biology and Biochemistry and Biology