Short CV/Education and training

  • 1987
    Abitur (A-levels), Gymnasium (grammar school), Cologne, Germany

  • 1988 – 1995
    Studied medicine at the University of Cologne; Harvard Medical School, Boston, USA; University of California, San Francisco, USA; University of Arizona, Phoenix, USA; University College Dublin, Ireland

  • 1995
    United States Medical Licensing Examinations I & II

  • 1995 – 1996
    Foundation year at the University Children's Hospital, Heidelberg, Germany

  • 1996 – 1997
    Postdoc at the German Cancer Research Centre (DKFZ)

  • 1997 – 2001
    Junior doctor at the University Children's Hospitals of Heidelberg and Ulm, Germany

  • 1998
    Postdoc at Institute Gustave Roussy, Villejuif, France

  • 2001
    Specialist examination in paediatrics

  • 2001
    Habilitation (postdoctoral qualification) and venia legendi (authorisation to teach) in the field of paediatrics in the Faculty of Medicine, Ulm University

  • 2002 – 2007
    Heisenberg Fellowship from the German Research Foundation (DFG)

  • 2007 – 2010
    DFG W3 research professorship in paediatrics research, Ulm University

  • Since 2010
    W3 professorship and director of the Institute of Experimental Tumour Research in Paediatrics, Goethe University Frankfurt, Germany

Selected publications

  • Fulda, S. et al.: Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo. In: Nat. Med. 8, 2002, pages 808-815.

  • Vogler, M. et al.: Small molecule XIAP inhibitors enhance TRAIL-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma. In: Cancer Res. 69, 2009, pages 2425-2434.

  • Fakler, M. et al.: Small molecule XIAP inhibitors prime childhood acute leukemia cells for TRAIL-induced apoptosis and overcome Bcl-2-mediated resistance. In: Blood 113, 2009, pages 1710-1722.

  • Loeder, S. et al.: A novel paradigm to trigger apoptosis in chronic lymphocytic leukaemia. In: Cancer Res. 69, 2009, pages 8977-8986.

  • Zibat A.: Activation of the hedgehog pathway confers a poor prognosis in embryonal and fusion gene negative alveolar rhabdomyosarcoma. In: Oncogene 29, 2010, pages 6323-30.

  • Haag, C. et al.: Identification of c-FLIPL and c-FLIPS as critical regulators of death receptor-induced apoptosis in pancreatic cancer cells. In: Gut 60, 2011, pages 225-37.

  • Häcker S.: Histone deacetylase inhibitors prime medulloblastoma cells for chemotherapy-induced apoptosis by enhancing p53-dependent Bax activation. In: Oncogene 30, 2011, pages 2275-2281.

  • Bender A.: PI3K inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic Bcl-2 proteins and enhanced mitochondrial apoptosis. In: Oncogene 30, 2011, pages 494-503.

  • Unterkircher T.: Bortezomib primes glioblastoma including glioblastoma stem cells for TRAIL by increasing tBid stability and mitochondrial apoptosis. In: Clin Cancer Res 17, 2011, pages 4019-30.

  • Naumann I.: Bortezomib primes neuroblastoma cells for TRAIL-induced apoptosis by linking the death receptor to the mitochondrial pathway. In: Clin Cancer Res 17, 2011, pages 3204-18.

  • Opel D.: Targeting aberrant PI3K/Akt activation by PI103 restores sensitivity to TRAIL-induced apoptosis in neuroblastoma. In: Clin Cancer Res 17, 2011, pages 3233-47.

  • Jennewein C.: Identification of a novel pro-apoptotic role of NF-kB in the regulation of TRAIL- and CD95-mediated apoptosis of glioblastoma cells. In: Oncogene, 2011 Aug 8. [Epub ahead of print].

  • Bangert A. et al.: Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP. In: Oncogene, 2011. In print.

  • Loeder S. et al.: RIP is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis. In: Leukemia, 2011. In print.

  • Fulda S. et al.: Targeting IAP proteins for therapeutic intervention in cancer. In: Nat Rev Drug Discov 2011. In print.

Selected projects

  • Director of the EU Seventh Framework Programme (FP7) project: Systems biology of apoptosis in cancer and AIDS

  • Director of EU project IAP6/18: Signal transduction in inflammation: from gene to organism

  • Director of the BMBF (German Federal Ministry of Education and Research) project: TranSaRNet – Translational sarcoma network

  • Director of German Research Foundation (DFG) Clinical Research Unit 167: Regulation of apoptosis and its dysfunction in human diseases, since 2006

  • Director of the Marie Curie Research Training Network: ApopTrain (European Commission, Sixth Framework Programme – FP6), since 2006

  • Director of the BMBF network: Apoptosis as a target in tumour therapy, within the framework of the funding programme "Innovative therapies on a molecular and cellular basis", since 2006

Membership in scientific bodies/juries


  • Advisory board of the German Society for Paediatric Oncology and Haematology

  • Board of directors, International Cell Death Society

  • Executive committee, APO-SYS Consortium (EU Seventh Framework Programme – FP7)

  • Scientific advisory board, LOEWE Oncogenic Signal Transduction priority programme

  • Advisory board of the Catalan Agency for Health Technology Assessment and Research, Barcelona, Spain

  • Advisory board of the Canceropole du Grand-Est, France

  • Advisory board of the Associazione Italiana per la Ricerca sul Cancro (AIRC), Italy

  • Selection committee, executive committee of the German National Academic Foundation

  • Deputy chairperson of the Ingrid zu Solms Foundation

  • Fellowship from the Ingrid zu Solms Foundation

  • Liaison between the German National Academic Foundation and students at Goethe University Frankfurt, Germany

Editorial boards:

  • Cancer Research, Cancer Letters, Anti-Cancer Drugs, Drug Resistance Updates, Genes & Cancer, International Journal of Oncology, Molecular and Cellular Pharmacology, Open Cancer Journal, Recent Patents on Anti-Cancer Drug Discovery, American Journal of Translational Research

Additional qualifications

  • "Leadership and Responsibility" professional development certificate from the Württemberg Management and Business Academy, 2007

  • Coaching as a Leadership Role: professional development seminar, 2007

  • Baden-Württemberg certificate of higher-education pedagogy (200 hours of instruction), 2005


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