Short CV/Education and training

  • 1986
    Abitur (A-levels) at the Gymnasium (grammar school) in Markdorf, Germany

  • 1986 – 1991
    Studied biology at the University of Konstanz, Germany

  • 1990 – 1991
    Wrote Diplom thesis under the Chair for biological chemistry, University of Konstanz

  • 1991
    Diplom degree in biology

  • 1991 – 1993
    Doctoral studies under the Chair for biological chemistry, University of Konstanz

  • 1992 – 1995
    Research associate in the biochemical and experimental section of the II Department of Surgery at the University of Cologne, Germany

  • 1993
    Doctor of Natural Science (Dr rer. nat.)

  • 1995 – 2001
    C1 research associate in the Medizinische Klinik III (medical clinic), Cardiology, Goethe University Frankfurt

  • Since 1997
    Head of the division of Molecular Cardiology at Goethe University Frankfurt

  • 1998
    Habilitation (postdoctoral qualification) in experimental medicine

  • 2001
    Appointed University professor of molecular cardiology (C3 professorship with tenure)

  • 2005
    Visiting Professor, Baylor College of Medicine, Houston, USA

  • Since 2006
    Visiting Professor, New York Medical College, USA

  • 2007
    Edmond Hustinx Chair, University of Maastricht, Netherlands

  • Since 2008
    W3 professor, director of the Director of the Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt

  • 2008
    Appointed to the Deutscher Ethikrat (German Ethical Committee) by the president of the German Bundestag

Selected publications

  • Dimmeler, S. et al.: Activation of the nitric oxide synthase in endothelial cells via Akt-dependent phosphorylation. In: Nature 399, 1999. pp. 601-605.

  • Dimmeler, S. et al.: Suppression of apoptosis by nitric oxide via inhibition of interleukin-1ß-converting enzyme (ICE)-like and cysteine protease protein (CPP-32)-like proteases. In: J. Exp. Med 185, 1997. pp. 601-607.

  • Dimmeler, S. et al.: HMG-CoA-reductase inhibitors (statins) increase endothelial progenitor cells via the PI3K/Akt pathway. In: J Clin Invest 108, 2001. pp. 391-397.

  • Assmus, B. et al.: Transplantation of Progenitor Cells and Re-generation Enhancement in Acute Myocardial Infarction (TOPCARE-AMI). In: Circulation 106, 202. pp. 3009-3017.

  • Haendeler, J. et al.: Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69. In: Nature Cell Biology 2002. pp. 743-749.

  • Aicher, A. et al.: Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. In: Nature Medicine 9, 2003. pp. 1370-1376.

  • Badorff, C., Dimmeler, S.: NO balance: regulation of the cytoskeleton in congestive heart failure by nitric oxide (Editorial). In: Circulation 107, 2003. pp. 1348-1349.

  • Chavakis, E. et al.: Role of ß2-integrins for homing and neovascularization capacity of endothelial progenitor cells. In: J Exp Med 201, 2005. pp. 63-72.

  • Urbich, C. et al.: Cathepsin L is required for endothelial progenitor cell-induced neovascularization. In: Nat Med 11, 2005. pp. 206-213.

  • Rössig, L. et al.: Histone deacetylase activity is essential for the expression of HoxA9 and for endothelial commitment of pro-genitor cells. In: J Exp Med 201, 2005. pp. 1825-1835.

  • Sasaki, K. et al.: Ex vivo pretreatment of bone marrow mononuclear cells with endothelial NO synthase enhancer AVE9488 enhances their functional activity for cell therapy. In: Proc Natl Acad Sci USA 103, 2006. pp. 14537-14541.

  • Assmus, B. et al.: Transcoronary transplanta-tion of progenitor cells after myocardial infarction. In: N Engl J Med 355, 2006. pp. 1222-1232.

  • Schächinger, V. et al.: Intra-coronary bone marrow-derived progenitor cells in acute myocardial infarction. In: N Engl J Med 355, 2006. pp. 1210-1221.


Selected projects

  • German Research Foundation (DFG):

  • Transregional Collaborative Research Centre SFB/TR 23

  • Excellence Cluster Cardio-Pulmonary System (ECCPS)

  • Collaborative Research Centre SFB 834

  • European Union (EU):

  • Integrated Project European Union (EU) Integrated Project Angioscaff, Endostem

  • Leducq Foundation Transatlantic Network of Excellence for Cardiac Regeneration

  • European Research Council (ERC)

Membership in scientific bodies/juries

  • Member of the German Cardiac Society – Heart and Circulation Research

  • Member of the German Society for Biochemistry and Molecular Biology (GBM)

  • German Society of Stemcell Research

  • Fellow of the American Heart Association

Member of the editorial board of the following journals:

  • Journal of Clinical Investigation, since 2005

  • Arteriosclerosis Thrombosis Vascular Biology (ATVB), since 2001

  • Basic Research in Cardiology, since 2001

  • Circulation, since 2001

  • Circulation Research, since 2000

Media coverage

Additional qualifications

  • Patents / Patent applications:

  • sCD40L as biochemical marker in cardiovascular disease (Heeschen/Zeiher/Hamm/Dimmeler) (DE 102 53 525.6, 16.11.06)

  • Circulating endothelial cells as diagnostic tool to assess cardiovascular disease progression (Rössig/Zeiher/Dimmeler) (PCT/EP03/12853, 17.11.03, WO 2004/046718 A1, 03.06.04)

  • Placental growth factor, a marker of vascular inflammation, as a diagnostic tool for patients with cardiovascular disease, as a tool to aid in the selection and as a target for the treatment of atherosclerotic disease (Heeschen/Dimmeler/Zeiher) (DE 103 16 059.0, 08.04.03)

  • Chemokine-induced cell migration, a marker for the functional activity of stem and progenitor cells, as a diagnostic tool for patients with cardiovascular disease, as a tool to aid in the selection for patients suitable for autologous cell therapy and as a target for the treatment of atherosclerotic disease (Heeschen/Zeiher/Dimmeler) (DE 103 47 436.6, 13.10.03)

  • Use of eNOS transcription enhancers in the cell therapy of ischemic heart diseases – enhanced expression of endothelial nitric oxide synthase using C2431 as a therapeutic tool to enhance stem/progenitor cell function prior to cell therapy for tissue regeneration and tissue neovascularisation (in cooperation with Aventis, Frankfurt) (Dimmeler/Zeiher/Heeschen)

  • Shock wave pre-treatment as a therapeutic tool for targeted recruitment of stem/progenitor cell (in cooperation with Dornier, Munich) (Dimmeler/Zeiher/Heeschen/Aicher)

  • Method for the promotion of angiogenesis, vascularisation, or vascular repair or for the inhibition of tumour angiogenesis (miR-92) (Dimmeler/Zeiher/Kühbacher/Urbich) (DE 102 0007052114.8 30.10.2007)


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News

  1. Stefanie Dimmeler Receives ERC Grant

    Professsor Stefanie Dimmeler gets the prestigious "Advanced Investigator Grant" from the European Research Council ERC for her pioneering research on non-coding RNAs. The grant is worth 2,5 million Euros for five years.