Short CV/Education and training

  • 1979 – 1985
    Diploma in Chemistry, University of Munich

  • 1989
    Dr. rer. nat. in Biochemistry, University of Munich

  • 1989 – 1991
    Postdoc, Medical School, University of Manchester

  • 1991 – 1997
    EMBO long term fellow and independent research group leader,Institute for Molecular Biology, University of Zürich, Switzerland

  • 1997 – 2004
    Leader of the independent Neurogenetics Research Group, Max-Planck-Institut für Hirnforschung, Frankfurt

  • 1999
    Habilitation for Molecular Biology, University of Zürich

  • Since 2005
    Full Professor for Functional Genomics (W3), Inst. for Pharmacy and Molecular Biotechnology IPMB, Heidelberg University

Selected publications

  • Caldwell et al.,(2013). Roles of the amyloid precursor protein family in the peripheral nervous system. Mech Dev 130(6-8):433.

  • Müller, UC and Zheng, H. (2012). Physiological Functions of APP Family Proteins, CSH Persp. Med 2(2):a006288.

  • Weyer et al., (2011). APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP. EMBO J, 30:2266-80.

  • Anliker et al., (2010). Specific gene transfer to neurons, endothelial cells and hematopoietic progenitors with lentiviral vectors. Nature Methods 7:929-35.

  • Bach et al., (2009). Vaccination with Aβ-displaying virus-like particles reduces soluble and insoluble cerebral Abeta and lowers plaque burden in APP transgenic mice.J. Immunology 182: 7613.

  • Ring et al., (2007) The secreted APPsalpha domain is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP deficient mice J. Neuroscience, 27: 7817-7826.

  • Herms et al., (2004). Cortical Dysplasia Resembling Human Type 2 Lissencephaly in Mice Lacking all Three APP-Family Members. EMBO J, 23: 4106.

  • Harvey et al., (2004). GlyRalpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization. Science, 304: 884.

  • Müller et al., (1994). Behavioral and Anatomical Deficits in Mice homozygous for a Modified beta-Amyloid Precursor Gene. Cell 79,755-765.

  • Müller at al., (1994). Functional role of Type I and type II Interferons in antiviral defense. Science 264,1918-1921.


Selected projects

  • Neuronal differentiation and synaptogenesis, molecular Neurogenetics, molecular mechanisms of synaptic transmission disorders and the pathogenesis of neurodegenerative diseases, e.g. Alzheimer´s disease, physiological and pathophysiological roles of proteins of the amyloid precursor protein family, physiology and function of neurotransmitter receptors

Membership in scientific bodies/juries

  • Speaker (coordinator) of the DFG Research Unit 1332 on "Physiological Functions of the APP gene family in the nervous system", since 2010

  • Speaker (coordinator) of the international ERANET Network neuAPPs, since 2013

  • Member of the Excellence Cluster: Cellular Networks, since 2007

  • Faculty member of The Hartmut-Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (HBIGS), since 2007

  • Dean of Studies Pharmacy, 2007 – 2011

  • Coordinator of the IPMB Graduate School, since 2006

  • Member of the Society of Neuroscience, USA

  • Member of the Society of Neuroscience, Germany

  • NGFNplus Nationales Genomforschungsnetz (BMBF), Netzwerk Alzheimer

Soft Skills/Other activities and achievements

Other activities and achievements/family

  • married, 2 children


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