Short CV/Education and training

  • Wiebke Arlt graduated from University of Cologne Medical School in 1990, followed by clinical training in Neurology, Psychiatry, General Internal Medicine in and Specialist Training in Endocrinology & Diabetes, the latter undertaken at the University Hospital Wuerzburg, Germany. From 1998 to 2000 she spent two years training in Molecular Endocrinology at the University of California at San Francisco (UCSF) funded by a DFG Postdoctoral Research Fellowship. In 2001 she was appointed DFG Heisenberg Senior Research Fellowship and moved to the University of Birmingham, UK, in 20002. There she was awarded an MRC Senior Clinical Research Fellowship in 2004, helping her to create a multi-disciplinary research group focusing on pre-receptor regulation of androgen synthesis and action. In 2006 she was promoted to Professor of Medicine and in 2008 she was appointed as the Head of the Centre of Endocrinology, Diabetes and Metabolism (CEDAM) at the University of Birmingham. As a consultant at the University Hospital Birmingham she specialises on adrenal and gonadal disorders and leads the adrenal tumour specialist service.

Selected publications

  • Dehydroepiandrosterone replacement in women with adrenal insufficiency. Arlt W, Callies F, van Vlijmen JC, Koehler I, Reincke M, Bidlingmaier M, Huebler D, Oettel M, Ernst M, Schulte HM, Allolio B. N Engl J Med. 1999 Sep 30;341(14):1013-20.

  • Beyond adrenal and ovarian androgen generation: Increased peripheral 5 alpha-reductase activity in women with polycystic ovary syndrome. Fassnacht M, Schlenz N, Schneider SB, Wudy SA, Allolio B, Arlt W. J Clin Endocrinol Metab. 2003 Jun;88(6):2760-6.

  • Congenital adrenal hyperplasia caused by mutant P450 oxidoreductase and human androgen synthesis: analytical study. Arlt W, Walker EA, Draper N, Ivison HE, Ride JP, Hammer F, Chalder SM, Borucka-Mankiewicz M, Hauffa BP, Malunowicz EM, Stewart PM, Shackleton CH. Lancet. 2004 Jun 26;363(9427):2128-35.

  • No evidence for hepatic conversion of dehydroepiandrosterone (DHEA) sulfate to DHEA: in vivo and in vitro studies. Hammer F, Subtil S, Lux P, Maser-Gluth C, Stewart PM, Allolio B, Arlt W. J Clin Endocrinol Metab. 2005 Jun;90(6):3600-5.

  • Inactivating PAPSS2 mutations in a patient with premature pubarche. Noordam C, Dhir V, McNelis JC, Schlereth F, Hanley NA, Krone N, Smeitink JA, Smeets R, Sweep FC, Claahsen-van der Grinten HL, Arlt W. N Engl J Med. 2009 May 28;360(22):2310-8.

  • Health status of adults with congenital adrenal hyperplasia: a cohort study of 203 patients. Arlt W, Willis DS, Wild SH, Krone N, Doherty EJ, Hahner S, Han TS, Carroll PV, Conway GS, Rees DA, Stimson RH, Walker BR, Connell JM, Ross RJ; United Kingdom Congenital Adrenal Hyperplasia Adult Study Executive (CaHASE). J Clin Endocrinol Metab. 2010 Nov;95(11):5110-21.

  • Urine steroid metabolomics as a biomarker tool for detecting malignancy in adrenal tumors. Arlt W, Biehl M, Taylor AE, Hahner S, Libé R, Hughes BA, Schneider P, Smith DJ, Stiekema H, Krone N, Porfiri E, Opocher G, Bertherat J, Mantero F, Allolio B, Terzolo M, Nightingale P, Shackleton CH, Bertagna X, Fassnacht M, Stewart PM. J Clin Endocrinol Metab. 2011 Dec;96(12):3775-84.

  • Clinical and biochemical consequences of CYP17A1 inhibition with abiraterone given with and without exogenous glucocorticoids in castrate men with advanced prostate cancer. Attard G, Reid AH, Auchus RJ, Hughes BA, Cassidy AM, Thompson E, Oommen NB, Folkerd E, Dowsett M, Arlt W*, de Bono JS*. J Clin Endocrinol Metab. 2012 Feb;97(2):507-16.

  • Mitotane Therapy in Adrenocortical Cancer Induces CYP3A4 and Inhibits 5?-Reductase, Explaining the Need for Personalized Glucocorticoid and Androgen Replacement. Chortis V, Taylor AE, Schneider P, Tomlinson JW, Hughes BA, O'Neil DM, Libé R, Allolio B, Bertagna X, Bertherat J, Beuschlein F, Fassnacht M, Karavitaki N, Mannelli M, Mantero F, Opocher G, Porfiri E, Quinkler M, Sherlock M, Terzolo M, Nightingale P, Shackleton CH, Stewart PM, Hahner S, Arlt W. J Clin Endocrinol Metab. 2013 Jan;98(1):161-71.

  • Hyperandrogenemia predicts metabolic phenotype in polycystic ovary syndrome: the utility of serum androstenedione. O'Reilly MW, Taylor AE, Crabtree NJ, Hughes BA, Capper F, Crowley RK, Stewart PM, Tomlinson JW, Arlt W. J Clin Endocrinol Metab. 2014 Mar;99(3):1027-36.


Membership in scientific bodies/juries

  • Member, Physiology and Systems Medicine Board, Medical Research Council UK, 2013-2017

  • Wellcome Trust Investigator Award Panel "Physiology in Health and Disease", Wellcome Trust, 2010-2013

  • Clinical Lecturer Starter Grant Panel, Academy of Medical Sciences, UK, 2011-2015

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News

  1. All About Hormones: Endocrinology

    Four AcademiaNet researchers are presented who study steroid hormones: Wiebke Arlt, Elisabet Stener-Victorin (photo), Inger Sundström Poromaa and Mirjam Christ-Crain.