Short CV/Education and training

  • 1985 – 1992
    Undergrad studies at the University of Vienna, Faculty of Natural Sciences. Major: Pharmacy

  • 1991
    Undergrad Fellow at the Academy of Sciences, Prague, Czech Republic (Advisor: Prof. Vaclav Horejsi)

  • 1991 – 1992
    Diploma thesis, University of Vienna Medical School, Institute of Immunology (Advisors: Prof. Hannes Stockinger). Degree granted 04/08/1992 (Mag. pharm.).

  • 1992 – 1998
    PhD, General Immunology and Immunodermatology. University of Vienna, Medical School (Advisor: Prof. Georg Stingl). Degree granted 10/21/1998.

  • 1999
    Postdoctoral fellow, University of Vienna, Medical School (Advisor: Prof. Dieter Maurer)

  • 2000 – 2005
    Postdoctoral fellow, Harvard Medical School (Advisor: Prof. Hidde Ploegh)

  • 2005
    Habilitation for Immunology at the Medical University of Vienna, affiliation as Assistant Professor of Immunology

  • 2005 – 2007
    Instructor for Pediatrics, Children's Hospital Boston and Harvard Medical School

  • Since 2007
    Assistant Professor of Pediatrics, Children's Hospital Boston and Harvard Medical School

Selected publications

  • Lennon-Dumenil, A.M. et al.: Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation. In: J Exp Med. 196(4), 2002. S. 529-540. PMC2196045

  • Fiebiger, E. et al.: Invariant chain controls the activity of extracellular cathepsin L. In: J Exp Med. 196(9), 2002. S. 1263-1269. PMC2194106

  • Fiebiger, E. et al.: Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin. In: Mol Biol Cell. 15(4), 2004. S. 1635-1646. PMC379262

  • Jaksits, S. et al.: Lipid raft-associated GTPase signaling controls morphology and CD8+ T cell stimulatory capacity of human dendritic cells. In: J Immunol. 173(3), 2004. S. 1628-1639. http://www.jimmunol.org/cgi/content/full/173/3/1628

  • Fiebiger, E. et al.: Cotranslational endoplasmic reticulum assembly of Fc{varepsilon}RI controls the formation of functional IgE-binding receptors. In: J Exp Med. 201(2), 2005. S. 267-277. PMC2212795

  • Dehlink, E. et al.: First evidence of a possible association between gastric acid suppression during pregnancy and childhood asthma: a population-based register study. In: Clin Exp Allergy 39(2), 2009. S. 246-253. PMC2745130

  • Singleton, T.E. et al.: The first transmembrane region of the beta-chain stabilizes the tetrameric FcvarepsilonRI complex. In: Mol Immunol. 46(11-12), 2009. S. 2333-2339. PMC2745130

  • Platzer, B., Fiebiger, E.: The signal peptide of the IgE receptor α-chain prevents surface expression of an immunoreceptor tyrosine-based activation motif (ITAM)-free receptor pool. In: J Biol Chem. 285(20), 2010. S. 15314-15323. PMC2865261

  • Yen, E. et al.: Comparative analysis of Fc epsilon RI expression patterns in patients with eosinophilic and reflux esophagitis. JPGN accepted for publication.

  • Dehlink, E. et al.: Relationships between levels of serum IgE, cell-bound IgE, and IgE-receptors on peripheral blood cells in a pediatric population. In: PLoS ONE 5(8), 2010. e12204.

  • Wurbel, M.-A. et al.: CCL25/CCR9 Interactions Regulate Large Intestinal Inflammation in a Murine Model of Acute Colitis. In: PLoS ONE, Jan 2011. 10.1371/journal.pone.0016442


Selected projects

  • Diploma thesis: The human leukocyte surface protein CD31: solubilisation, isolation, and molecular association studies

  • PhD thesis: Circulating IgG antibodies directed against the alpha-chain of the high affinity receptor for IgE, FcepsilonRI

Postdoctoral projects:

  • Studies on MHC class II processing and antigen presentation in human dendritic cells

  • Analysis of proteases involved in MHC class II processing and antigen degradation with inhibitors of the peptide vinyl sulfone class

  • Studies on ER quality control and deubiquitinating enzymes

    Receptor assembly studies focusing on FcEpsilonRI

Current research projects:

  • Studies on FcEpsilonRI as an antigen presentation structure at mucosal surfaces

  • Studies on establishing diagnostic markers for eosinophilic esophagitis

  • IgE-transgenic animals as models for food allergy

Membership in scientific bodies/juries

  • Österreichische Gesellschaft für Allergologie und Immunologie (ÖGAI)

  • Österreichische Gesellschaft für Dermatologie und Venerologie (ÖGDV)

  • American Association of Immunologists (AAI)

  • Austrian scientists and scholars in North America (AsciNA)

  • North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN)

  • American Gastroenterological Association (AGA)

Additional qualifications

Funding

  • NIH, RO1 funding for studies on IgE-mediated immune responses on mucosal surfaces, 2009

  • NIH, R56 funding for studies on IgE-mediated immune responses on mucosal surfaces, 2008

  • American Gastrointestinal Association Foundation Research Scholar Award, 2008

  • Gerber Foundation Grant, 2008

  • CDHNF Young Investigator Development Award, NASPGHAN, 2007

  • Harvard Digestive Disease Center Pilot Project Grant, 2007

  • Junior Faculty Award at Children's Hospital Boston, Eleanor and Miles Shore Foundation, 2006

  • Fellowship of the Royal Academy of Sciences, UK, 5-year award, declined, 2004

  • Charles King Trust Fellowship, 2003

  • APART Fellowship, Austrian Academy of Sciences, 2002

  • Max Kade Fellowship, Max Kade Foundation New York and Austrian Academy of Sciences, 2001

  • Erwin Schrödinger Fellowship of the FWF Austria, 1999-2000

Invited Talks and Seminars

  • IgE-mediated immune responses – pushing late phase responses in allergy. Harvard Digestive Disease Center, Boston, 2009

  • Controlling IgE-receptors, controlling allergy – GI-ID Research Seminar Series, Children's Hospital, Boston, 2008

  • The high affinity receptor for IgE: What controls the receptor? What does the receptor control? Children's Hospital, Boston; Seminar for the Division of Immunology, Host: Dr. Raif S. Geha, 2008

  • Fc-epsilon-RI in the human gastrointestinal tract, GI-ID Research Seminar Series, Children's Hospital, Boston, 2007

  • Cysteine Proteases control the elicitation of MHC II-dependent immune responses. Austrian Academy of Physicians, Vienna, Billrothhaus, 2006

  • Publish or perish: efficient writing strategies for bench scientists. Keynote teaching lecture at the retreat of the PhD program of the Medical University Vienna, 2006

  • The role of ER quality control for the elicitation of immune responses. Department of Dermatology, Brigham&Women's Hospital, Boston, hosted by Prof. Marianne Boes, 2006

  • Control of surface expression of immune recognition receptors in the ER. Center for Human Genetics, Oxford University, Oxford, hosted by Prof. Elizabeth Robertson, 2004

  • Immunevasion: how viral proteins trick the immune system.

    AsciNA (Austrian scientists and scholars in North America), Boston, 2003

  • Visualization of the ER-to-cytosol dislocation reaction of a type I membrane protein, November 2001, AKH, DIAID, Dept. of Dermatology, hosted by Prof. Dieter Maurer, 2003

  • MHC class II antigen presentation in human dendritic cells.

    Harvard Medical School, hosted by Prof. H. Ploegh, 1999

  • The role of Cathepsin S in the li degradation of human dendritic cells, Harvard Medical School, Dept. of Pathology, hosted by Prof. H. Ploegh, 1998

  • Cathepsin S – a key enzyme in allergy? Brigham and Women's Hospital, Dept. of Pulmonology, hosted by Prof. H. Chapman, 1998


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