Short CV/Education and training

  • Since 2019
    Director General European Molecular Biology Laboratory (EMBL)

  • Since 2012
    Professor at the Collège de France, Chair of Epigenetics and Cellular Memory

  • Since 2010
    Director of the Genetics and Developmental Biology Department, UMR 3215-U934 Institut Curie, Paris, France

  • 2008 – 2010
    Co-Director with Prof. Spyros Artavanis Tsakonas, of the Genetics and Developmental Biology Department, UMR 3215-U934, Institut Curie, Paris, France

  • 2006 – 2008
    Senior Group Leader, Mammalian Developmental Epigenetics team, Institut Curie, Paris (France), CNRS UMR218 Unit of Dr. G. Almouzni

  • 2001 – 2006
    Junior Group leader (CNRS ATIPE), Institut Curie, Paris (France), CNRS UMR218, Unit of Dr. G. Almouzni

  • 2000 – 2001
    Visiting Scientist, Cold Spring Harbor Laboratory (NY, USA). Lab. of Dr. D. Spector

  • 1993 – 2000
    CNRS research scientist position (CR2, then CR1) Pasteur Institute, Paris (France), Lab. of Dr. P. Avner

  • 1990 – 1993
    Postdoctoral Fellow (HFSP and Wellcome Trust funding), URA 1968, Pasteur Institute, Paris (France). Lab. of Dr. P. Avner

Selected publications

  • Giorgetti L†., Lajoie, B.†, Carter, A.C.†, Attia, M†., Zhan, Y., Xu, J., Chen, C.J., Kaplan, N., Chang, H.Y., Heard, E.* and J. Dekker* (2016) Structural organization of the inactive X chromosome. Nature 535: 575-579

  • Chaligné, R. Popova, T., Mendoza-Parra, M-A. , Saleem, M., Gentien, D., Ban, K. Piolot, T., Leroy, O., Mariani, O., Gronemeyer, H*., Vincent-Salomon, A.*, Stern, M-H*. and Heard, E.*. (2015) The inactive X chromosome is epigenetically unstable and transcriptionally labile in breast cancer. Genome Res. 4:488-503.

  • Giorgetti, L., Galupa, R., Nora, EP., Lam, F., Piolot, F., Dekker, J., Tiana, G*. and Heard, E*. (2014) Predictive polymer modeling reveals coupled fluctuations in chromosome conformation and transcription. Cell 157: 950–963.

  • Nora E.P., Lajoie B., Schulz E.G., Giorgetti L., Okamoto I., Servant N. Piolot T., van Berkum N.L., Meisig J., Sedat J., Barillot E., Blüthgen N., Dekker J.* and Heard E*. (2012) Spatial partitioning of the regulatory landscape of the X-inactivation center. Nature 485: 381-385.

  • Gendrel, A-V., Attia, M., Chen, C., Diabangouaya, P., Servant, N., Barillot, E. and Heard, E. (2014) The developmental dynamics and disease potential of random monoallelic gene expression. Developmental Cell, 28: 366–380.

  • Schulz, E., Meisig, J., Nakamura, T., Okamoto, I., Sieber, A., Picard, C., Borensztein, M., Saitou, M., Bluthgen, N. and Heard E. (2014) The two active X chromosomes in female embryonic stem cells block exit from the pluripotent state by modulating the ES cell signaling network. Cell Stem Cell, 14: 203-16.

  • Okamoto I., Patrat C., Thepot D., Peynot,N., Diabangouya, P., Fauque P., Daniel N., Wolf JP., Renard JP., Duranthon V*. and Heard E*. (2011) Evolutionary Diversity of X-chromosome Inactivation in Mammals. Nature 472 : 370-374.

  • Masui O., Bonnet I., Le Baccon P., Brito I., Pollex T., Murphy N., Hupé P., Barillot E., Belmont A. and Heard E. (2011) Live cell chromosome dynamics and outcome of X-chromosome pairing events during ES cell differentiation. Cell 145: 447-458.

  • Okamoto, I., Arnaud, D., Otte, AP, Disteche, C., Avner, P. and Heard E. (2005) Evidence for de novo imprinted X-chromosome inactivation independent of meiotic inactivation in mice. Nature 438: 369-373.

  • Okamoto, I., Otte, A., Allis, C. D., Reinberg, D. and Heard, E. (2004) Epigenetic dynamics of imprinted X inactivation during early mouse development. Science 303: 644-649.


Membership in scientific bodies/juries

Advisory Board / Scientific Committees

  • Scientific Advisory Board of the EMBL, 2017

  • Scientific Advisory Board of the Hubrecht Institute (Utrecht, Netherlands), since 2017

  • Scientific Advisory Board of the BRIC (Copenhagen, Denmark), since 2017

  • Scientific Advisory Board of the Crick Institute (London, UK), since 2016

  • Scientific Advisory Board of the Institut de Génétique Humaine (Montpellier, France), since 2014

  • Scientific Advisory Board of the Institut de Génétique Humaine (Montpellier, France)

  • EMBO Young Investigator Program, 2008- 2012

  • ITMO Génétique Génomique Bioinformatique, since 2009

  • INSERM Institut de Développement et Génétique, 2008 – 2009

  • CNRS ATIP scientific board – Development section, 2006 – 2009

  • INSERM commission CT1 (Epigenetics–Development -Cancer study section), 2003 – 2007

  • Curie Institute Research Section scientific board, since 2004

  • French Genetics Society board, since 2003

Ad-hoc expertise

  • Reviewer for major journals eg Cell, Science, Nature, Nature Genetics, Development, Journal of Cell Biology, Genes and development, Journal of Cell Science and others

  • Expert for international and national funding bodies including: ERC, BBRC, EMBO, Human Frontier of Science, NSF (USA), Wellcome Trust (UK), Riken (Japan) and others

Editorial Activities

  • Editor special issue Seminars in Cell and Developmental Biology: Epigenetics and Disease

  • Editor special issue of Chromosome Research on Dosage Compensation

  • Editor of Henry Stewart Lecture Series on Epigenetics (CD)

  • Editorial Board of PlOS ONE, Chromatin and Epigenetics

Participation in Scientific Networks

  • EU EpiGeneSys Network of Excellence, since 2011

  • EU Epigenome Network of Excellence, 2004 – 2010

  • GDR Epigenetique, 2002 – 2006

  • “Breast Cancer and Epigenetics” Canceropole IDF, since 2004

  • Réseau ARECA, ARC “Epigentique et Cancer”, 2005 – 2008

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