Short CV/Education and training

University Education

  • 1970 – 1974
    University of St. Andrews, BSc 2.i Biochemistry

  • 1974 – 1975
    University of Edinburgh, M.Sc. in Human Genetics, Supported by the Medical Research Council, Thesis entitled "The Cystic Fibrosis Factor".

  • 1975 – 1978
    University of Edinburgh, Ph.D. in Human Genetics, Supported by the Medical Research Council, Thesis entitled “Biochemical and Immunological Investigation into Cystic Fibrosis”.

Career since Graduation

  • 1978 – 1981
    Research Fellow in the Department of Human Genetics, University of Edinburgh. Funded by the Cystic Fibrosis Research Trust. Development of a diagnostic assay for cystic fibrosis.

  • 1981 – 1986
    Research Fellow, Dept. of Molecular Biology, University of Edinburgh. Supported by the Science and Engineering Research Council. Transposable DNA elements associated male sterile in maize.

  • 1986 – 1988
    Research Fellow Department of Medicine, University of Edinburgh supported by the Arthritis and Rheumatism Council for Research. Regulation of cytokine gene expression in arthritis.

  • 1989 – 1996
    Senior Scientific Officer (Band 5) IAH, NPU, I established and directed a research programme aimed at understanding the role of PrP in TSEs.

  • 1996 – 2003
    Principle Scientific Officer (Band 4), IAH, NPU directing a research a group of 16 people.

  • since 2003
    Head of the Neurobiology Division of The Roslin Institute (formerly TSE Division of the Institute for Animal Health)

Selected publications

  • Krejciova Z, De Sousa P, Manson J, Ironside J, Head M (2014) Human tonsil-derived follicular dendritic-like cells are refractory to human prion infection in vitro and traffic disease-associated prion protein to lysosomes. Am. J. Pathol. 184(1): 64-70.

  • Bishop M., Diack A., Ritchie D., Ironside, Will R., Manson J. (2013) Prion infectivity in the spleen of a PRNP heterozygous individual with subclinical variant Creutzfeldt-Jakob disease. Brain 136(4): 1139-45.

  • Piccardo P, King D, Telling G, Manson J, Barron R (2013) Dissociation of prion protein amyloid seeding from transmission of a spongiform encephalopathy. J. Virol. 87(22): 12349.

  • Cancellotti E, Mahal S, Somerville R, Diack A, Brown D, Piccardo P, Weissmann C, Manson J (2013) Post-translational changes to PrP alter transmissible spongiform encephalopathy strain properties. EMBO 32: 756-69.

  • Diack, A, Ritchie D, Bishop, M, Pinion V, Brandel J-P, Haik, S, Tagliavini F, Van Duijn, C, Belay, E D, Gambetti, P, Schonberger, L B, Piccardo, P, Will, R G, Manson, J C (2012) Constant transmission properties of variant Creutzfeldt-Jakob disease in 5 countries. Emerging Infectious Diseases 18: 1574-9.

  • Lewis, V.; Whitehouse, I.J.; Baybutt, H.; Manson, J.C.; Collins, S.J.; Hooper, N.M. Cellular prion protein expression is not regulated by the Alzheimer's amyloid precursor protein intracellular domain. (2012) PLoS One 7: e31754.

  • Moda, F.; Suardi, S.; Di Fede, G.; Indaco, A.; Limido, L.; Vimercati, C.; Ruggerone, M.; Campagnani, I.; Langeveld, J.; Terruzzi, A.; Brambilla, A.; Zerbi, P.; Fociani, P.; Bishop, Matthew; Will, R.G.; Manson, J; Giaccone, G.; Tagliavini, F. (2012) MM2-thalamic Creutzfeldt-Jakob disease: neuropathological, biochemical and transmission studies identify a distinctive prion strain. Brain Pathol. 22: 662-669

  • Tan, B-C; Alejo-Blanco R; Houston F., Stewart P., Goldmann W., Gill A., de Wolf C., McCutcheon S., Manson J. ( 2012) Significant differences in incubation times in sheep infected with BSE result from variation at codon 141 in the PRNP gene. J. Gen. Virol., 93: 2749-56.

  • Jeffrey M, McGovern G, Chambers E, King D, González L, Manson J, Ghetti B, Piccardo P, Barron R (2012) Mechanism of PrP-amyloid formation in mice without transmissible spongiform encephalopathy. Brain Pathol. 22: 58-66.

  • McCutcheon S, Alejo-Blanco A, Houston E, deWolf C, Tan B, Smith A, Groschup M, Hunter N, Hornsey V, MacGregor I, Prowse C, Turner M, Manson J.(2011) All clinically-relevant blood components transmit prion disease following a single blood transfusion: a sheep model of vCJD. PLOS One 6: e23169.


Membership in scientific bodies/juries

  • Member of the WHO Transmissible Spongiform Encephalopathies Working Group – since 1999

  • Member of the CJD Sample Oversight Committee – since 2007

  • Member of the SEAC – a government advisory body – 2004-2011

  • Chair of the STN, which I established in 2004 with the aim of promoting excellence in TSE scientific research and a better public understanding of the TSEs

  • Member of the Executive Committee of NeuroPrion

  • Member of the Advisory Committee on Dangerous Pathogens (ACDP) – since 2011

  • Member of the ACDP, TSE Working Group – since 2007

  • Member of the British Neuroscience Association Scientific Advisory Committee – since 2009

  • Member of Scientific Advisory Committee for Alberta Prion Research 2012

  • Established and co-ordinate the Interdisciplinary Group of Dementia and Neurodegenerative Disease for the University of Edinburgh

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