Short CV/Education and training

  • 1983 – 1987
    Bachelor in Science (Biology): distinction licent in biology (zoology): great distinction at the Free University Brussels (VUB) Thesis: "The micronucleus assay as an assay for genome and chromosome mutations". This work was performed in collaboration with the department Toxicology of the company Janssens Pharmaceuticals at Beerse, Belgium.

  • 1988
    Aggregation HSO (VUB) with distinction

  • 1990
    Partial programm of Medical and Pharmaceutical Research (VUB)(Immunology, Cancer Research, Cell Technology, Cell Pathology)

  • 1994
    PhD in Sciences (biology) with greatest distinction

Selected publications

  • K. Vanderkerken, K. Asosingh, F. Braet, I. Van Riet, B. Van Camp. Insulin-like growth factor-1 acts as a chemoattractant factor for 5T2 multiple myeloma cells. Blood 93, 235-241 (1999)

  • K. Asosingh, H. De Raeve, I. Van Riet, B. Van Camp, K. Vanderkerken.MultIFle myeloma tumor progression in the 5T2 murine model is a multi-stage and dynamic process of differentiation, proliferation, invasion and apoptosis. Blood, 101: 3136-3141 (2003)

  • K. Vanderkerken, K. Asosingh, P. Croucher, B. Van Camp. Multiple myeloma biology: lessons from the 5TMM models..Immunological Reviews ,194:196-206 (2003)

  • K. Asosingh, A. Willems, I. Van Riet, B. Van Camp, K. Vanderkerken. Delayed in vivo disease is associated with high proportions of CD45+ myeloma cells in the 5T2 murne model. Cancer Research 2003 63(12):3019-20 (2003)

  • K. Asosingh, H. De Raeve, E. Menu, I. Van Riet, E. Van Marck, B. Van Camp, K. Vanderkerken. Angiogenic switch during 5T2MM murine myeloma tumorigenesis; role of CD45 heterogeneity. Blood, 103(8):3131-7 (2004)

  • E. Menu, H. Jernberg Wiklund, T. Stromberg, H. De Raeve, L. Girnita, O. Larsson, M. Axelson, K. Asosingh, K. Nilsson, B. Van Camp, K. Vanderkerken. Inhibiting the IGF-1 receptor tyrosine kinase swith the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model. Blood 107 655-660 (2006)

  • T. Stromberg, S. Ekman, L. Girnita, LY. Dimberg, O. Larsson, M. Axelson, J. Lennartsson, U. Hellman, K. Carlson, A. Osterborg, K. Vanderkerken, K. Nilsson, H. Jernberg-Wiklund.IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells. IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells. Blood 107 669-678 (2006)

  • Deleu S, Lemaire M, Arts J, Menu E, Van Valckenborgh E, King P, Vande Broek I, De Raeve H, Van Camp B, Croucher P, Vanderkerken K. The effect of JNI-26481585, a novel hydroxamate-based histone deacetylase inhbitor, on the development of multiple myeloma in the 5T2MM and 5T33MM murine models. Leukemia Oct;23(10):1894-903. (2009)

  • De Bruyne E, Bos TJ, Schuit F, Van Valckenborgh E, Menu E, Thorrez L, Atadja P, Jernberg-Wiklund H, Vanderkerken K. IGF-1 suppresses Bim expression in multiple myeloma via epigenetic and posttranslational mechanisms. Blood. 115(12):2430-40 (2010)

  • Hu J, Handisides DR, Van Valckenborgh E, De Raeve H, Menu E, Vande Broek I, Liu Q, Sun JD, Van Camp B, Hart CP, Vanderkerken K.Targeting the multiple myeloma hypoxic niche with TH-302, a hypoxia-activated prodrug.Blood. 116(9):1524-7 (2010)


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