Short CV/Education and training

EDUCATION

  • 1998
    PhD in experimental physics, University of Southern Denmark

  • 1995
    Cand. Scient., specialization in mathematics and physics, University of Southern Denmark

  • 1992
    Bachelor of Science, specialization in mathematics and physics, University of Southern Denmark

EMPLOYMENTS

  • Since 2015
    Center leader for StemPhys, a Danish National Research Foundation Center of Excellence, Denmark

  • Since 2015
    Professor at the Niels Bohr Institute (NBI), Denmark

  • Since 2003
    Group Leader for the Optical Tweezers Group ( ~15 people), NBI, Denmark

  • 2003 – 2014
    Tenured associate professor at the NBI, Denmark

  • 1998 – 2003
    Assistant professor at NBI, in experimental biological physics. Responsible for constructing the optical tweezers laboratory, this was the first optical trapping facility in Scandinavia, Denmark

  • 1996 – 1997
    Visiting graduate student at the James Frank Institute, University of Chicago, in the group of Professor Sidney R. Nagel, USA

GRANTS

  • 2015 – 2021
    Danmarks Grundforskning Center of Excellence ‘StemPhys: Stem Cell Decision making’, 60 mio Dkr, PI: LBO

  • 2015 – 2018
    Novo Nordisk Foundation Synergy Grant ‘LANTERN: Laser activated nanoparticles for tumor elimination’, 14.5 mio Dkr, PI: LBO

  • 2014 – 2017
    FNU Research Project 2 ‘Force mapping during cancer cell division and invasion’, 6 mio Dkr, PI: LBO

  • 2012 – 2014
    Lundbeckfonden Center for active nanoparticles, 2.5 mio Dkr, PI: LBO

  • 2010 – 2013
    Lundbeckfonden Center for complexity of amyloid formation, 5 mio Dkr, PI: M. Høgh Jensen, LBO one of 3 co-applicants

  • 2010 – 2015
    Lundbeckfonden Center for biomembranes in nanomedicine, 36 mio Dkr, PIs: D. Stamou and U. Gether, LBO one of 7 co-applicants

  • 2009
    FNU Equipment, Danish research councils, 1.2 mio Dkr, PI: LBO

  • 2008
    - 2013 Excellence Center at University of Copenhagen, 20 mio Dkr, PI: LBO

  • 2004
    - 2009 BioNET a Villum Kann Rasmussen Center, 25 mio Dkr, PI: M. Høgh Jensen, LBO one of 9 co-applicants

  • 2006
    - 2008 FNU Rammebevilling Danish Research Councils, 600.000 Dkr, PI: LBO

  • 2006
    Carlsbergfoundation, Equipment 1 mio Dkr, PI: LBO

  • 1999
    - 2004 FREJA grant Danish Research Councils, 6 mio Dkr, PI K. Berg-Sørensen, LBO co-applicant

  • 1995
    - 1998 PhD fellowship from Danish Research Councils, applicant: LBO

Selected publications

  • N.S. Rossen, J.M. Tarp, J. Mathiesen, M.H. Jensen, L.B. Oddershede. Long-range ordered vorticity patterns patterns in living tissue induced by cell division. Nature Communications, vol. 5 p. 5720 (1-7) (2014).

  • K. Norregaard, M. Andersson, P.E. Nielsen, S. Brown, L.B. Oddershede. Tethered particle analysis of supercoiled circular DNA using PNA handles. Nature Protocols, vol. 9 p. 2206 (2014).

  • H. Ma, P. Tian, J. Pello, P.M. Bendix, L.B. Oddershede. Heat generation by irradiated complex composite nanostructures. Nano Letters, vol. 14 p.612-619 (2014).

  • K. Norregaard, M. Andersson, K. Sneppen, P.E. Nielsen, S. Brown, L.B. Oddershede. DNA supercoiling enhances cooperativity and efficiency of an epigenetic switch. PNAS, vol. 110 p.17386-17391 (2013).This paper prompted an invitation for an Addendum in Bacteriophage 2014.

  • T. Jakociunas, M.D. Jordo, M.A. Mebarek, C.M. Bunner, J. Verhain-Hansen, L.B. Oddershede, G. Thon, Subnuclear relocalization and silencing of a chromosomal region by an ectopic rDNA repeat, PNAS, vol. 110 p.E4465-E4473 (2013).

    Rated as 'of outstanding interest' in Curr Opinion in Cell Bio. vol. 28 p. 54 (2014).

  • H. Ma, P.M. Bendix, L.B. Oddershede. Large-Scale Orientation Dependent Heating from a Single Irradiated Gold Nanorod. Nano Letters vol.12 p.3954-3960 (2012).

  • L.B. Oddershede. Force probing of individual molecules inside the living cell is now a reality. Nature Chemical Biology, vol 8 p.879-886 (2012).

  • P. Gross, N. Laurens, L.B. Oddershede, U. Bockelmann, E.J.G. Peterman, G.J.L. Wuite. Quantifying how DNA stretches, melts and changes twist under tension, Nature Physics vol. 7 p.731-736 (2011).

  • A. Kyrsting, P.M. Bendix, D.G. Stamou, and L.B. Oddershede. Heat Profiling of Three-Dimensionally Optically Trapped Gold Nanoparticles using Vesicle Cargo Release. Nano Letters, vol 11 p.888-892 (2011).

  • J.H. Jeon, V. Tejedor, S. Burov, E. Barkai, C. Selhuber, K. Berg-Sørensen, L. Oddershede, R. Metzler. In vivo anomalous diffusion and weak ergodicity breaking of lipid granules. Physical Review Letters, vol. 106 p.048103 (2011). This paper received the CeNS award for an outstanding publication.



Complete list of publications

Selected projects

  • Stem cell decision making

  • Development of a plasmon based cancer therapy

  • Force mapping during cancer cell division and migration

Membership in scientific bodies/juries

  • Member of the Royal Danish Academy of Sciences and Letters, since 2014

  • Danish member of ERC COST action no 1205 (optics and microfluidics), 2012 – 2016

  • Danish National Committee for Biophysics, since 2007

  • NBI Visionary and Strategic Committee, 2003 and 2008 – 2013

  • Board of BIOP graduate school, 2003 – 2005

  • NBI educational committee, 2003 – 2010

  • Board of high-technological network for biophotonics, 2005 – 2006

  • Committee of Future Education in Natural Sciences, 2002 – 2003

Additional qualifications

  • LBO is expert on in vivo manipulation of living matter from the single molecule to whole cell level, on optical manipulation of individual metallic nanoparticles, on matter-light-nanoparticle interactions, and on in vitro investigations of nucleic acids. Methodologically, areas of expertise include optical manipulation, force spectroscopy, fluorescent visualization (also super-resolution), and single particle tracking.


Soft Skills/Other activities and achievements

Other activities and achievements/family

  • Lene B. Oddershede was born in 1970.

    She is married to Ulrich J. Quaade and they have 3 sons born 1997, 2000 and 2006.


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