Short CV/Education and training

  • EDUCATION:

    • 1998 PhD in experimental physics, University of Southern Denmark

    • 1995 Cand. Scient., specialization in mathematics and physics, University of Southern Denmark

    • 1992 Bachelor of Science, specialization in mathematics and physics, University of Southern Denmark

  • EMPLOYMENTS:

    • Center leader for StemPhys, a Danish National Research Foundation Center of Excellence since April 2015.

    • Professor at the Niels Bohr Institute (NBI) since January 2015.

    • Group Leader for the Optical Tweezers Group ( ~15 people), NBI, since 2003.

    • Tenured associate professor at the NBI 2003-2014.

    • Assistant professor at NBI, 1998-2003, in experimental biological physics. Responsible for constructing the optical tweezers laboratory, this was the first optical trapping facility in Scandinavia.

    • Visiting graduate student at the James Frank Institute, University of Chicago, in the group of Professor Sidney R. Nagel, 1996-1997.

  • GRANTS:

    • 2015-2021 Danmarks Grundforskning Center of Excellence ‘StemPhys: Stem Cell Decision making’, 60 mio Dkr, PI: LBO.

    • 2015-2018 Novo Nordisk Foundation Synergy Grant ‘LANTERN: Laser activated nanoparticles for tumor elimination’, 14.5 mio Dkr, PI: LBO.

    • 2014-2017 FNU Research Project 2 ‘Force mapping during cancer cell division and invasion’, 6 mio Dkr, PI: LBO.

    • 2012-2014 Lundbeckfonden Center for active nanoparticles, 2.5 mio Dkr, PI: LBO.

    • 2010-2013 Lundbeckfonden Center for complexity of amyloid formation, 5 mio Dkr, PI: M. Høgh Jensen, LBO one of 3 co-applicants.

    • 2010-2015 Lundbeckfonden Center for biomembranes in nanomedicine, 36 mio Dkr, PIs: D. Stamou and U. Gether, LBO one of 7 co-applicants.

    • 2009 FNU Equipment, Danish research councils, 1.2 mio Dkr, PI: LBO.

    • 2008-2013 Excellence Center at University of Copenhagen, 20 mio Dkr, PI: LBO.

    • 2004-2009 BioNET a Villum Kann Rasmussen Center, 25 mio Dkr, PI: M. Høgh Jensen, LBO one of 9 co-applicants.

    • 2006-2008 FNU Rammebevilling Danish Research Councils, 600.000 Dkr, PI: LBO.

    • 2006 Carlsbergfoundation, Equipment 1 mio Dkr, PI: LBO.

    • 1999-2004 FREJA grant Danish Research Councils, 6 mio Dkr, PI K. Berg-Sørensen, LBO co-applicant.

    • 1995-1998 PhD fellowship from Danish Research Councils, applicant: LBO.

Selected publications

  • N.S. Rossen, J.M. Tarp, J. Mathiesen, M.H. Jensen, L.B. Oddershede. Long-range ordered vorticity patterns patterns in living tissue induced by cell division. Nature Communications, vol. 5 p. 5720 (1-7) (2014).

  • K. Norregaard, M. Andersson, P.E. Nielsen, S. Brown, L.B. Oddershede. Tethered particle analysis of supercoiled circular DNA using PNA handles. Nature Protocols, vol. 9 p. 2206 (2014).

  • H. Ma, P. Tian, J. Pello, P.M. Bendix, L.B. Oddershede. Heat generation by irradiated complex composite nanostructures. Nano Letters, vol. 14 p.612-619 (2014).

  • K. Norregaard, M. Andersson, K. Sneppen, P.E. Nielsen, S. Brown, L.B. Oddershede. DNA supercoiling enhances cooperativity and efficiency of an epigenetic switch. PNAS, vol. 110 p.17386-17391 (2013).This paper prompted an invitation for an Addendum in Bacteriophage 2014.

  • T. Jakociunas, M.D. Jordo, M.A. Mebarek, C.M. Bunner, J. Verhain-Hansen, L.B. Oddershede, G. Thon, Subnuclear relocalization and silencing of a chromosomal region by an ectopic rDNA repeat, PNAS, vol. 110 p.E4465-E4473 (2013).

    Rated as 'of outstanding interest' in Curr Opinion in Cell Bio. vol. 28 p. 54 (2014).

  • H. Ma, P.M. Bendix, L.B. Oddershede. Large-Scale Orientation Dependent Heating from a Single Irradiated Gold Nanorod. Nano Letters vol.12 p.3954-3960 (2012).

  • L.B. Oddershede. Force probing of individual molecules inside the living cell is now a reality. Nature Chemical Biology, vol 8 p.879-886 (2012).

  • P. Gross, N. Laurens, L.B. Oddershede, U. Bockelmann, E.J.G. Peterman, G.J.L. Wuite. Quantifying how DNA stretches, melts and changes twist under tension, Nature Physics vol. 7 p.731-736 (2011).

  • A. Kyrsting, P.M. Bendix, D.G. Stamou, and L.B. Oddershede. Heat Profiling of Three-Dimensionally Optically Trapped Gold Nanoparticles using Vesicle Cargo Release. Nano Letters, vol 11 p.888-892 (2011).

  • J.H. Jeon, V. Tejedor, S. Burov, E. Barkai, C. Selhuber, K. Berg-Sørensen, L. Oddershede, R. Metzler. In vivo anomalous diffusion and weak ergodicity breaking of lipid granules. Physical Review Letters, vol. 106 p.048103 (2011). This paper received the CeNS award for an outstanding publication.



Complete list of publications

Selected projects

  • Stem cell decision making

  • Development of a plasmon based cancer therapy

  • Force mapping during cancer cell division and migration

Membership in scientific bodies/juries

  • Member of the Royal Danish Academy of Sciences and Letters (since 2014)

  • Danish member of ERC COST action no 1205 (optics and microfluidics) (2012-2016)

  • Danish National Committee for Biophysics (since 2007)

  • NBI Visionary and Strategic Committee (2003 and 2008-2013)

  • Board of BIOP graduate school (2003-2005)

  • NBI educational committee (2003-2010)

  • Board of high-technological network for biophotonics (2005-2006)

  • Committee of Future Education in Natural Sciences (2002-2003)

Media coverage

  • Danish television:

  • 2015 March 4th on TV2: http://www.tv2lorry.dk/arkiv/2015/3/4?video_id=101180

  • http://www.dr.dk/nyheder/viden/her-er-aarets-eliteforskere

  • 2014: http://video.ku.dk/1026869.ihtml/player.html?source=share&photo_id=9035521

  • Newspapers:

  • Berlingske tidende February 2015: http://www.b.dk/nationalt/kvinden-med-verdens-mindste-pincet

  • The Danish scientific magazine 'Videnskab.dk': http://videnskab.dk/krop-sundhed/kroppen-kan-selv-fjerne-blodpropper

  • http://videnskab.dk/teknologi/kan-laserlys-og-nanopartikler-erstatte-kemoterapi

Additional qualifications

  • LBO is expert on in vivo manipulation of living matter from the single molecule to whole cell level, on optical manipulation of individual metallic nanoparticles, on matter-light-nanoparticle interactions, and on in vitro investigations of nucleic acids. Methodologically, areas of expertise include optical manipulation, force spectroscopy, fluorescent visualization (also super-resolution), and single particle tracking.


Soft Skills/Other activities and achievements

Other activities and achievements/family

  • Lene B. Oddershede was born in 1970.

    She is married to Ulrich J. Quaade and they have 3 sons born 1997, 2000 and 2006.


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