Short CV/Education and training

  • 1982
    B. Sc. in Biology. Universidad Autónoma. Madrid. Spain

  • 1983
    M. Sc. in Biochemistry. Universidad Autónoma. Madrid. Spain

  • 1985 – 1987
    Postdoctoral Fello. Spanish Research Council. Centre for Molecular Biology (CBMSO)

  • 1987
    Ph. D. in Biochemistry. Universidad Autónoma. Madrid. Spain

  • 1988 – 1989
    Postdoctoral Fellow. Spanish Ministry of Education and Science at IIB. CSIC. Madrid. Spain

  • 1989 – 1991
    Grantee of the Science Plan (E.U.) National Institute for Medical Research. London. UK

  • 1991 – 1992
    Scientist at the National Institute for Medical Research. London. UK

  • 1993 – 2000
    Assistant Professor and Group Leader. Cajal Institute. Madrid. Spain

  • 2000 – 2003
    Associate Professor. Cajal Institute. Madrid. Spain

  • 2003 – 2004
    Full Professor. Cajal Institute. Madrid. Spain

  • Since 2004
    Full Professor and Head of Developmental Neurobiology at the Instituto de Neurociencias. CSIC-UMH. Alicante. Spain

Selected publications

  • Nieto, M.A., Sargent, M., Wilkinson, D.G. and Cooke, J. (1994) Control of cell behavior during vertebrate development by Slug, a zinc-finger gene. Science 264, 836-840.

  • Cano, A., Pérez, M. A., Rodrigo, I., Locascio, A., Blanco, M. J., Del Barrio, M. G., Portillo, F. and Nieto, M. A. (2000). The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nature Cell Biol. 2, 76-83.

  • Nieto, M. A. (2002). The Snail superfamily of zinc finger transcription factors.Nature Rev. Mol. Cell Biol. 3, 155-166.

  • Locascio, A., Manzanares, M., Blanco, M.J. and Nieto, M.A. (2002). Modularity and reshuffling of Snail and Slug expression during vertebrate evolution.Proc. Natl. Acad. Sci. USA. 99, 16841-16846.

  • Blanco, M.J., Moreno-Bueno, G., Sarrio, D., Locascio, A., Cano, A., Palacios, J. and Nieto, M.A. (2002). Correlation of Snail expression with histological grade and lymph node status in breast carcinomas.Oncogene 21, 3241-3246.

  • Vega, S., Morales, A.V., Ocaña, O., Valdés, F., Fabregat, I. and Nieto, M.A. (2004). Snail blocks the cell cycle and confers resistance to cell death. Genes Dev. 118, 1131-1143.

  • Boutet, A., De Frutos, C.A., Maxwell, P.H., Mayol, M.J., Romero, J. and Nieto, M.A. (2006). Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney. EMBO J. 25, 5603-5613

  • De Frutos, C.A., Vega, S., Manzanares, M., Flores, J.M., Huertas, H., Martinez-Frías, M.L. and Nieto M.A. (2007). Snail 1 is a trasncriptional effector of FGFR3 signaling during chondrogenesis and achondroplasias. Dev. Cell 13, 872-883.

  • Acloque, H., Adams, M., Fishwick, K., Bronner-Fraser, M. and Nieto, M.A. (2009). Epithelial-mesenchymal transitions: The importance of changing cells? state in development and disease.J. Clin. Invest. 119, 1438-1449.

  • De Frutos, C.A., Dacquin, R., Vega, S., Jurdic, P., Machuca-Gayet, I. and Nieto, M.A. (2009). Snail1 controls bone mass by regulating Runx2 and VDRexpression during osteoblast differentiation. EMBO J. 28, 686-696.

  • Thiery, J.P., Acloque, H., Huang, R.Y. and Nieto, M.A. (2009). Epithelial-mesenchymal transitions in development and disease: the remarkable plasticity of the mesenchymal state. Cell 139, 871-890.

  • Acloque, H., Ocaña, O.H., Matheu, A., Rizzoti, K., Wise,C., Lovell-Badge, R. and Nieto, M.A. (2011). Reciprocal repression between Sox3 and Snail transcription factors defines embryonic territories at gastrulation. Dev. Cell.21, 546-558.

  • Rodriguez-Aznar, E. and Nieto, M.A. (2011).Repression of Puma by Scratch2 is required for neuronal survival during embryonic development. Cell Death Diff.18, 1196-1207.

  • Nieto, M.A. (2011).The ins and outs of the Epithelial to mesenchymal transition in health and disease.Ann. Rev. Cell Dev. Biol. 27, 347?376.

  • Ocaña, O.H., Córcoles, R., Fabra, A., Moreno-Bueno, G., Acloque, H., Vega, S., Barrallo-Gimeno, A., Cano, A. and Nieto, M.A. (2012). Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. Cancer Cell22, 709-724.


Selected projects

  • Polymeric nanostructures as synthetic vectors in gene therapy. Application to siRNA intracellular delivery: use of conditional transgenic models. NAN2004-09230-C04-04.2008.

  • Functional and evolutive analysis of the Snail superfamily. MEC-BFU2005-05772/BMC.2005-2008.

  • Cancer Biology. MICINN Ingenio 2010. Consolider. 2007 – 2012.(I.P. Subproject 9).

  • Functional analysis of the Snail family in Physiology and Pathology. Generalitat Valenciana. Prometeo 2008/049. 2009 – 2012

  • Snail and Prx gene families in physiology and pathology. BFU2008-01042/BMV. 2008-2013. 2009- 2013.

  • The role of Snail factor inskeletal development: physiology and pathology. 2010HK0010. 2011- 2013.

  • STEMT. ISIC 2012/010. 2012 – 2017

  • EMTASY. ERG AdG 322694. 2013 – 2018.

Membership in scientific bodies/juries

  • Head of Developmental Neurobiology Unit. Insitituto Neurociencias.

  • President of the Spanish Society of Developmental Biology (SEBD)

  • Vicechair of the European Molecular Biology Conference (EMBC)

  • Spanish Scientific Delegate for the European Molecular Biology Laboratory (EMBL) and EMBC

  • President of the EMT International Association (TEMTIA)

  • Member of the Board of Directors of the International Society of Differentiation (ISD)

  • Member of the European Molecular Biology (EMBO)

Advisory Boards / Scientific Committees

  • Member of CONCYTEC. Permanent Research and Technology Council of the Government of Valencia.

  • Member of ACCGV. High Advisory Council of the Valencian Government.

  • Member of Scientific Advisory Committee (SAC) National Center for Oncological Research (CNIO), Madrid

  • Member of SACCenter for Genomic Regulation (CRG), Barcelona

  • Member of SAC Ramón y Cajal Hospital, Madrid

  • Member of SAC Centro de Ciencias de Benasque Pedro Pascual

  • Member of SAC Biomedical Research Institute. IDIBELL. Barcelona

  • Member of SAC Andalusian Centre for Developmental Biology (CABD). Seville.

  • Member of Committee for tercentennial celebration of the Spanish National Library

  • Member of the Advisory Board for Editors at EMBO Publications.

Editorial Boards

  • EMBO J, EMBO reports, Current Opinion in Genetics and Development, Mechanisms of Development, Gene Expression Patterns and Int. J. Dev. Biol.

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