Short CV/Education and training

Education / professional experience / academic appointments

  • 2002 – 2003
    Diploma work under the supervision of Prof. D. Neri (Swiss Federal Institute of technology Zurich (ETHZ), Zurich)

  • 2004
    Studies of Molecular Biology completed with Diploma Degree at the University of Zurich. Specialisations: Molecular Biology and Immunology/Biochemistry

  • 2004 – 2007
    PhD under the supervision of Prof. F. Sallusto and Prof. A. Lanzavecchia (Institute for Research in Biomedicine (IRB), Bellinzona)

  • 2007 – 2010
    Post-doctoral position in Prof. J. Tschopp's group (UNIL, Biochemistry Department)

  • 2010 – 2012
    Senior lecturer position in the group of Prof. J. Tschopp (UNIL, Biochemistry Department)

  • Since 2012
    Assistant Professor funded by the wiss National Science Foundation (SNSF) (University of Lausanne (UNIL), Biochemistry Department)

Selected publications

  • G. Guarda, C. Dostert, F. Staehli, K. Cabalzar, R. Castillo, A. Tardivel, P. Schneider and J. Tschopp. Activated T lymphocytes dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes. Nature, 2009 Jul 9; 460(7252):269-73

  • G. Guarda*, M. Zenger*, A. Yazdi, K. Schroder, I. Ferrero, P. Menu, A. Tardivel , C. Mattmann and J. Tschopp. Differential NLRP3 expression among hematopoietic cells. The Journal of Immunology, 2011 Feb 15;186:2529-2534

  • G. Guarda*, M. Braun*, F. Staehli, A. Tardivel, I. Förster, M. Farlik, T. Decker, R.A. Du Pasquier, P. Romero and J. Tschopp. Type I IFN inhibits IL-1 production and inflammasome activation. Immunity, 2011 Feb 25;34:213-223

  • F. Staehli, K. Ludigs, L.X. Heinz, I. Ferrero, M. Braun, K. Schroder, M. Rebsamen, A. Tardivel, C. Mattmann, H.R. MacDonald, P. Romero, G. Guarda*,° and J. Tschopp*. NLRC5-deficiency selectively impairs MHC class I-dependent lymphocyte killing by cytotoxic T cells. The Journal of Immunology, 2012 Apr 15;188: 3820-3828

    *Shared senior authorship; °Corresponding author

  • MC. Michallet, G. Rota and G. Guarda. Innate receptors for adaptive immunity. Current Opinion in Microbiology, 2013 Jun;16(3):296-302

  • K. Ludigs°, Q. Seguín-Estévez°, S. Lemeille°, I. Ferrero, G. Rota, S. Chelbi, C. Mattmann, H. R. MacDonald, W. Reith* and G. Guarda*. NLRC5 specifically transactivates MHC class I and related genes through a distinctive SXY module. Plos genetics, 2015 Mar, DOI:10.1371/journal.pgen.1005088 °These authors contributed equally to this work; *Shared senior authorship

Selected projects

  • European Research Council Starting Grant; project entitled: "NLRs AS TRANSCRIPTIONAL REGULATORS", 2013 – 2018

  • Swiss National Science Foundation Professorship; project entitled: "T CELL-INTRINSIC ROLE OF PATTERN RECOGNITION RECEPTORS", 2012 – 2016


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