Short CV/Education and training

  • 1993
    MsSc in Chemistry and Pharmaceutical Technology, Federico II University of Naples, Italy

  • 1994 – 1995
    CNR Postgraduate Fellow, Federico II University of Naples

  • 1995 – 1999
    PhD student in Cellular and Molecular Genetics, Federico II University of Naples

  • 2000
    PhD in Cellular and Molecular Genetics, Federico II University of Naples

  • 1997 – 2000
    Marie Curie Fellow, Institute of Molecular Pathology (IMP), Vienna, Austria

  • 2000 – 2003
    Research Associate, Telethon Institute of Genetics and Medicine (TIGEM), Naples

  • 2003 – 2010
    Group Leader (Associate Investigator), TIGEM

  • 2003
    EMBO Young Investigator (YIP)

  • 2004 – 2010
    Lecturer, European School of Molecular Medicine (SEMM), Naples

  • 2005
    Marie Curie Excellence Award

  • 2009
    Associate Investigator, Institute of Genetics and Biophysics (IGB), CNR, Naples

  • 2010
    ICREA Research Professor and Senior Group Leader, Centre for Genomic Regulation (CRG), Barcelona, Spain

  • 2010
    EMBO Member

Selected publications

  • Lluis F, Ombrato L, Pedone E, Pepe S, Merrill BJ, Cosma MP. T-cell factor 3 (Tcf3) deletion increases somatic cell reprogramming by inducing epigenome modifications. PNAS (2011) Jul 19;108(29):11912-7.

  • Buono M, Visigalli I, Bergamasco R, Biffi A, and Cosma MP (2010). SUMF1-mediated FGF signaling primes multilineage development Hematopoietic Stem and Progenitor Cells. J Exp Med.Aug 2;207(8):1647-60.

  • Cantone I, Marucci L, Iorio F, Ricci MA, Belcastro V, Bansal M, di Bernardo M, Santini D, di Bernardo D and Cosma MP (2009). A yeast synthetic network for In-vivo assessment of reverse-engineering and modelling approaches. Cell Apr 3;137(1):172-81

  • Polito V and Cosma MP (2009). IDS crossing of the blood-brain barrier corrects CNS defects in MPSII mice. AJHG Aug;85(2):296-301.

  • Lluis F, Pedone E, Pepe S, Cosma MP (2008). Periodic activation of Wnt/?-catenin signalling enhances somatic cell reprogramming mediated by cell fusion. Cell Stem Cell. Nov 6;3(5):493-507

  • Zito E, Fraldi A, Buono M, Pepe S, Settembre C, Annunziata I, Surace EM, Dierks T, Monti M, Cozzolino, M, Pucci P, Ballabio A and Cosma MP. (2007) Sulfatase modifying factor 1 trafficking through the cells: from endoplasmic reticulum to the endoplasmic reticulum. EMBO Journal Apr 19. May 16;26(10):2443-53.

  • Cosma MP, Pepe S, Annunziata A, Newbold RF, Grompe M, Parenti G, and Ballabio A. (2003). The Multiple Sulfatase Deficiency Gene Encodes an Essential and Limiting Factor for the Activity of Sulfatases. Cell, Vol. 113:445-456

  • Cosma MP (2002) Ordered recruitment: gene-specific mechanism of transcription activation. Molecular Cell, Vol. 10, 227-236

  • Cosma MP, Panizza S and Nasmyth K (2001) Cdk1 triggers association of RNA polymerase to cell cycle promoters only after recruitment of the mediator by SBF. Molecular Cell, Vol. 7(6): 1213-1220

  • Cosma MP, Tanaka T and Nasmyth K (1999) Ordered recruitment of transcription and chromatin remodeling factors to a cell cycle- and developmentally regulated promoter. Cell, Vol. 97(3):299-311



Complete list of publications

Selected projects

  • Identification of beta-catenin targets and molecular pathways that control cell reprogramming, and analysis of their interactions via network-identification algorithms.

  • To determine whether Wnt/beta-catenin-dependent reprogramming of fused cells is a mechanism of regeneration in higher vertebrates.

Membership in scientific bodies/juries

  • Human Frontier Science Programme (HFSP) (member of evaluation Panel for Long Term HFSP Fellowships, years 2008-2010)

  • European Molecular Biology Organization (EMBO)

Media coverage

Public Outreach

  • Scientific achievements have been reported in several Italian and Spanish newspapers from 2003 up to now.

Additional qualifications

Patents

  • Diagnosis and treatment of Multiple Sulfatase Deficiency and other sulfatase deficiencies (WO/2004/072275 and PCT Application PCT/US04/03632)

  • Method for reprogramming differentiated cells. (WO/2009/101084 and PCT/EP2009/051512)

Lecturer for PhD courses

  • Stazione Zoologica Anton Dohrn, Naples

  • TIGEM Institute, Naples

  • Instituto Gulbenkian de Ciência, Oeiras, Portugal

  • EMBO practical course “Deciphering Chromosomes by Chromatin Immunoprecipitation”

  • SEMM, Naples

  • Open University (UK), Naples

  • Synthetic Biology, Università di Padova

Invited Speaker in Universities and Research Insitutes, among others:

  • MIT, Whitehead, Cambridge, USA 1999; University of Milan, Italy, 1999; Stazione Zoologica "Anton Dohrn", Naples,Italy, 2000; OHSU, Portland, USA, 2000; La Sapienza, University of Rome, Italy, 2003; St. Jude Children’s Research Hospital, Memphis, USA, 2003; University of Pavia, Italy, 2004; Sanger Center, Cambridge, UK, 2006; Shire pharmaceutical, Boston, USA, 2007; Mario Negri Sud, Santa Maria in Baro, Chieti, Italy, 2007; Federico II, University of Naples, Italy, 2008; VIB, Lueven, Belgium 2008; IEO, Milan, Italy 2009; University of Siena, Italy 2009; IRB, Barcelona, Spain 2011; CNIO, Madrid, Spain 2011; CCBR, Cambridge, UK 2011

Invited Speaker for a selection of meetings, among others:

  • European Society of Human Genetics 2004, Monaco; DGZ Annual Meeting of German Society for Cell Biology 2005, Heidelberg, Germany; ELSO 2005 Heidelberg, Germany; CRUI 2006, ERC meeting Bologna; Festival della Scienza 2006, Genova; Scientificamente 2007, Cattolica, Glycobiology meeting, Boston 2007; University of Basilicata, Potenza 2008; Golgi meeting 2008, Pavia, Italy; SIBBM 2009, Naples, Italy; Unistem 2010, Milan; EMBO meeting 2010, Barcelona; CSLH Systems Biology 2010, Hinxton, UK; Yeast Model Convention 2010, La Sapienza, Roma, Italy; DTI meeting, Taormina 2010; Annual SCB Meeting 2010; Catalan Society of Biology, Barcelona, Spain; Fundación Duques de Soria 2010, Madrid, Spain; AIMPS 2011, Senago (MI), Italy; ABCD 2011, Ravenna, Italy; EMBO Members 2011, Heidelberg; Crossroads in Biology 2012, Cologne, Germany


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