Short CV/Education and training

Education

  • 1969 – 1972
    B.Sc. Chemistry (Cum Laude), the Hebrew University of Jerusalem, Israel.

  • 1972 – 1977
    Ph.D. in Chemical Immunology, Department of Chemical Immunology, Weizmann Institute of Science, Israel.

  • 1977 – 1978
    Postdoctoral Fellow, Department of Chemical Immunology, Weizmann Institute of Science, Israel. Research field: Neuroimmunology

  • 1978 – 1980
    Postdoctoral fellow, Department of Neuroscience, University of Michigan, Ann Arbor, MI, USA. Research subject: Nerve regeneration

Academic Appointments

  • 1980
    - 1985 Senior Scientist, Department of Neurobiology, Weizmann Institute of Science, Israel

  • 1985 – 1998
    Associate Professor with Tenure, Department of Neurobiology, Weizmann Institute of Science, israel.

  • since 1987
    Maurice and Ilse Katz Professorial Chair in Neuroimmunology.

  • since 1998
    Professor, Department of Neurobiology, Weizmann Institute of Science.

  • 1988 – 1992
    Visiting Professor, Department of Anatomy, Medical College of Pennsylvania, PA, USA.

  • 2009 – 2011
    Visiting Professor Cedars-Sinai Medical Center, Neurosurgery Department, LA, USA.

  • 2009 – 2011
    Visiting Professor, UCLA, Department of Psychiatry, LA, USA.

  • since 2011
    Visiting honorary doctor, University of Manchester, UK.

Selected publications

  • Rapalino O, Lazarov-Spiegler O, Agranov E, Velan GJ, Yoles E, Fraidakis M, Solomon A, Gepstein R, Katz A, Belkin M, Hadani M, Schwartz M. 1998. Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats. Nature Medicine 4: 814-21.

  • Moalem G, Leibowitz-Amit R, Yoles E, Mor F, Cohen IR, Schwartz M. 1999. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nature Medicine 5: 49-55.

  • Ziv Y, Ron N, Butovsky O, Landa G, Sudai E, Greenberg N, Cohen H, Kipnis J, Schwartz M. 2006. Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood. Nature Neuroscience 9: 268-75.

  • Rolls A, Shechter R, London A, Ziv Y, Ronen A, Levy R, Schwartz M. 2007. Toll-like receptors modulate adult hippocampal neurogenesis. Nature Cell Biology 9: 1081-8.

  • Shechter R, London A, Varol C, Raposo C, Cusimano M, Yovel G, Rolls A, Mack M, Pluchino S, Martino G, Jung S, Schwartz M. 2009. Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice. PLoS Medicine 6: e1000113

  • London A, Itskovich E, Benhar I, Kalchenko V, Mack M, Jung S, Schwartz M. 2011. Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages. J Exp Med 208: 23-39.

  • Shechter R, Miller O, Yovel G, Rosenzweig N, London A, Ruckh J, Kim KW, Klein E, Kalchenko V, Bendel P, Lira SA, Jung S, Schwartz M. 2013. Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus. Immunity 38: 555-69.

  • Kunis G, Baruch K, Rosenzweig N, Kertser A, Miller O, Berkutzki T, Schwartz M. 2013. IFN-γ-dependent activation of the brain’s choroid plexus for CNS immune surveillance and repair. Brain 136: 3427-40

  • Baruch K, Deczkowska A, David E, Castellano JM, Miller O, Kertser A, Berkutzki T, Barnett-Itzhaki Z, Bezalel D, Wyss-Coray T, Amit I, Schwartz M. 2014. Science 346: 89-93.

  • Baruch, K., Rosenzweig, N., Kertser, A., Deczkowska, A., Sharif, A., Spinrad, A., Tsitsou-Kampeli, A., Sarel, A., Cahalon, L., Schwartz, M. (2015) Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer’s disease pathology. Nature Communications. In press



Complete list of publications

Selected projects

  • Deciphering the cellular, molecular, and genomic regulation underlying the involvement of circulating macrophages and T cells in supporting CNS repair:

    -Network regulation of immune cells in the circulation.

    -Immune cell entry to the CNS following injury; temporal, spatial and phenotype regulation.

    -Mechanism of action within the CNS.

    -Development of immune cell-based therapy for CNS traumatic injury

  • In depth understanding of how the immune system supports healthy brain plasticity, and the implications to brain ageing and mental dysfunction:

    -Types of immune cells

    -Location and mechanism of action.

  • Understanding the cellular, molecular and genomic regulation of the "permissive" immunological interface between the brain and the circulation, the brain’s choroid plexus.

  • Understanding how the fate of the immune system affects the brain, via the activity of the choroid plexus interface, in ageing and neurodegenerative disease, and searching for approaches to modulate immune activity for therapy. Development of immune-based therapeutic strategies to chronic neurodegenerative diseases.

Membership in scientific bodies/juries

  • Scientific advisor board of the European Society of Neuroimmunology.

  • Scientific advisor board of the Inrernational society of Neuroimmunology

  • Promotion committee for the rank of associate professor with tenure and full professor, Weizmann Institute (2012-2015)

  • Life science Promotion committee for the rank of associate professor with tenure and full professor, Weizmann Institute of Science (2010-2015)

  • European Research Commission , Evaluation Panel (2013, 2015)

  • Promotion committee for senior scientists, Weizmann Institute of Science (3 years)

Past committees

  • Life Science Education Committee, The Feinberg graduate School, The Weizmann Institute (several years)

  • Ad-hoc member of promotion committees for associate and full professors at the Hebrew University of Jerusalem.

  • Ad-hoc member of promotion committees for associate and full professors, Bar-Ilan University.

  • Ad-hoc member of promotion committees for associate and full professors, Tel Aviv University.

  • Chairperson of grant committees, Israel Academy of Science (twice); a member several times.

  • Chairperson of grant committees, Israel Academy of Science (several times).

  • Member of the Alon National Fellowship committee for young investigators

  • Member of grant committees, Israel Ministry of Health (several times).

  • Member of grant committees for the Glaucoma Research Foundation (several times).

  • Member of Germany ministry of Education and Research grant committee.

Additional qualifications

  • Selected Honorary lectures (of 270 invited lectures in symposia, conferences, workshops)

  • Presidential lecture, International Congress of Academy of Ophthalmology. June, 1998.

  • Keynote lecture, FASEB Summer Conference on Interaction of the Nervous and the Immune Systems. Copper Mountain, CO, USA, July, 1998.

  • Award lecture, Alcon Research Institute Symposium (Alcon Awardee for Outstanding Contributions in the Field of Vision Research). Texas, USA, March 1999.

  • The 3rd International symposium on Ocular Pharmacology and Pharmaceutics – ISOPP, (keynote lecturer). Lisbon, February, 2000.

  • Honorary Lecturer of the 22nd Annual Peter and Eva Safar Lecture, University of Pittsburgh, December 2001.

  • Awardee lecture, distinguished lectureship, The G. Heiner Sell Memorial Lectureship in the Joint meeting of the American Spinal Injury Association and the International Medical Society of Paraplegia, Vancouver, Canada, May 2002.

  • Awardee lecture, Association for Research in Vision and Ophthalmology (Lecturer as Recipient of the Friedenwald Award), Fort Lauderdale, Florida, May 2002.

  • Presidential lecture, European Neurological Society Meeting. Istanbul, Turkey, June 2003.

  • Keynote lecture, American Uveitis Society Meeting. Ft. Lauderdale, Florida, May 2003.

  • Presidential lecture, European Neurological Society Meeting. Istanbul, Turkey, June 2003.

  • Keynote lecture. Kentucky Spinal Cord Injury Research Trust Symposium. Louisville, Kentucky, June 2003.

  • Presidential Lecture, in the annual meeting of the Psychoneuroimmunology Research Society, Breckenridge Colorado, June 3-6, 2009.

  • Keynote lecture, University of Sydney- Israel Research Partnership Forum “Shared Challenges, Future Solutions”. October 31, 2011.

  • Presidential Lecture, Canadian Association of Neuropathologists, Mont Tremblant, Quebec, October 25-27, 2012.

  • Sweden Neuroscience day, May 2013, Lund, Sweden

  • Keynote Lecture, British Society for Research on Ageing, University of East Anglia, Norwich, UK 2013

  • Selected scientist in “Meet-the-Experts”, by the Society for Neuroscience, The 44rd Annual Society for Neuroscience Meeting, Washington, 2014.

  • Award lecture, International Conference "Allergy and Immunology-view to future", January 25-26, Moscow, 2015.

  • The Gabriele M. Zu Rhein lectureship, University of Wisconsin-Madison, November, 2015.


Soft Skills/Other activities and achievements

Other activities and achievements/family

  • Married and a mother of 4 children


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