Short CV/Education and training

  • 1993
    PhD in Medical Sciences, School of Medicine, University of Utrecht

  • 1992
    PhD in “Pharmacology”, Faculty of Pharmacy, University of Milan

  • 1986
    Laurea cum laude in Chemistry and Pharmacology Technology, Faculty of Pharmacy, University of Milan

Selected publications

  • Elongation factor-2 phosphorylation in dendrites and the regulation of dendritic mRNA translation in neurons. Heise C, Gardoni F, Culotta L, Di Luca M, Verpelli C, Sala C. Front Cell Neurosci. 2014 Feb 10;8:35.

  • Region-specific restoration of striatal synaptic plasticity by dopamine grafts in experimental parkinsonism. Rylander D, Bagetta V, Pendolino V, Zianni E, Grealish S, Gardoni F, Di Luca M, Calabresi P, Cenci MA, Picconi B. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):E4375-84.

  • Aβ leads to Ca²⁺ signaling alterations and transcriptional changes in glial cells. Grolla AA, Fakhfouri G, Balzaretti G, Marcello E, Gardoni F, Canonico PL, DiLuca M, Genazzani AA, Lim D. Neurobiol Aging. 2013 Feb;34(2):511-22.

  • Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease. Marcello E, Saraceno C, Musardo S, Vara H, de la Fuente AG, Pelucchi S, Di Marino D, Borroni B, Tramontano A, Pérez-Otaño I, Padovani A, Giustetto M, Gardoni F, Di Luca M. J Clin Invest. 2013 Jun 3;123(6):2523-38.

  • Effects of central and peripheral inflammation on hippocampal synaptic plasticity. Di Filippo M, Chiasserini D, Gardoni F, Viviani B, Tozzi A, Giampà C, Costa C, Tantucci M, Zianni E, Boraso M, Siliquini S, de Iure A, Ghiglieri V, Colcelli E, Baker D, Sarchielli P, Fusco FR, Di Luca M, Calabresi P. Neurobiol Dis. 2013 Apr;52:229-36.

  • The neuropeptide PACAP38 induces dendritic spine remodeling through ADAM10/N-Cadherin signaling pathway. Gardoni F, Saraceno C, Malinverno M, Marcello E, Verpelli C, Sala C and Di Luca M. J Cell Science, 2012, 125(Pt 6) :1401-6. Epub 2012 Feb 10.

  • Malinverno M, Carta M, Epis R, Marcello E, Verpelli C, Cattabeni F, Sala C, Mulle C, Di Luca M, Gardoni F. Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-Cadherin cleavage J Neurosci, 2010 Dec 1; 30(48) :16343-55.

  • Epis R, Marcello E, Gardoni F, Vastagh C, Malinverno M, Balducci C, Colombo A, Borroni B, Vara H, Dell'agli M, Cattabeni F, Giustetto M, Borsello T, Forloni G, Padovani A, Di Luca M. Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer's disease. Brain. 2010 Nov; 133(11) :3323-35

  • Gardoni F, Mauceri D, Malinverno M, Polli F, Costa C, Tozzi A, Siliquini S, Picconi B, Cattabeni F, Calabresi P, Di Luca M. Decreased NR2B subunit synaptic levels cause impaired long-term potentiation but not long-term depression. J Neurosci. 2009 Jan 21; 29(3) :669-677.

  • Marcello E, Gardoni F, Mauceri D, Romorini S, Jeromin A, Epis R, Borroni B, Cattabeni F, Sala C, Padovani A, Di Luca M. Synapse-associated protein-97 mediates alpha-secretase ADAM 10 trafficking and promotes its activity. J Neurosci. 2007 Feb 14; 27(7) :1682-91.

  • Picconi B, Gardoni F, Centonze D, Mauceri D, Cenci MA, Bernardi G, Calabresi P, Di Luca M. Abnormal Ca2+-calmodulin-dependent protein kinase II function mediates synaptic and motor deficits in experimental parkinsonism. J Neurosci. 2004 Jun 9; 24(23) :5283-91.

  • Colciaghi F, Marcello E, Borroni B, Zimmermann M, Caltagirone C, Cattabeni F, Padovani A, Di Luca M. Platelet APP, ADAM 10 and BACE alterations in the early stages of Alzheimer disease. Neurology. 2004 Feb 10; 62(3) :498-501.

  • Gardoni F, Schrama LH, Kamal A, Gispen WH, Cattabeni F, Di Luca M. Hippocampal synaptic plasticity involves competition between Ca2+/calmodulin-dependent protein kinase II and postsynaptic density 95 for binding to the NR2A subunit of the NMDA receptor. J Neurosci. 2001 Mar 1; 21(5) :1501-9.



Complete list of publications

Selected projects

  • JPco-fuND, Synapse-to-nucleus communication in Alzheimer's disease (STAD), 2015

  • H2020-MSCA-ITN-2015, SyDAD, Partner, Programme n. 676144, Synaptic Dysfunction in Alzheimer Disease, Innovative Training Networks (ITN) – Marie Skłodowska-Curie Actions, 2015

  • Cariplo Foundation, Shaping and reshaping the synapses: from physiology to Intellectual Disability syndromes, 2013

  • 7 Framework Programme, Symbad, Partner, Programme n. 238608, Synapses: from Molecules to higher Brain function and Diseases. ITN Marie Curie programme, 2009 – 2013

  • Cariplo Foundation, Role of calcium dependent gene expression and protein trafficking in shaping post synaptic activity: implication for neurodegenerative diseases, 2008-2010

  • 7 Framework Programme, Coordinator, Programme n: 222918, REPLACES, Restorative Plasticity At Corticostriatal Excitatory Synapses, 2008 – 2012

  • 7 Framework Programme, Coordinator, Programme n: 217902, cPADs, Cell permeable peptides as drug delivery system: a way towards innovative therapeutic strategies for neurodegeneration, 2008 – 2010

  • 6 Framework Programme, Coordinator, Programme n. 511995, SYNSCAFF, Synaptic Scaffolding Proteins orchestrating cortical synapse organization during development, 2005 – 2007

Membership in scientific bodies/juries

  • Italian Interdisciplinary Network on Alzheimer Disease, ITINAD, Scientific Secretary: 1998 – 2001; Vice President: 2001 – 2009

  • SINDEM – Società Italiana Neurologia delle Demenze, Board Member: since 2012

  • SINEG – Società Italiana di Neurogeriatria, Board Member 2005 – 2009

  • SINS – Società Italiana di Neuroscienze, Board Member 2001 – 2005

  • SIF – Società Italiana di Farmacologia, Coordinator for “Regione Lombardia”: since 2007; Coordinator Group of Neurodegenerative Diseases: 2012; Member of Advisory Board: 2013 – 2017

  • EBC – European Brain Council, Member of Advisory Board: 2003 – 2006; Vice-president: since 2010

  • European Neurosciences Association, Member: 1994 – 1998

  • IBRO, International Brain Organization, Chair of Wester Europe Regional Committee: 2006 – 2010; Executive Director Inter-Regional activities, 2010 – 2014

  • FENS – Federation of European Neuroscience Societies, Member of Scientific Programme Committee: 1996 – 2000; General Secretary: 2000 – 2006

  • Member of Board Programme of European Neuroscience Schools, PENS: 2006 – 2010; President 2014 – 2016)

  • Federation of European Neuroscience Societies Trust, President: since 2006

  • EDAB, European Dana Alliance, Invited Member: 2008

  • SfN – Society for Neuroscience, Member of Women in Neuroscience Committee: 2007 – 2010; Member of Professional Development Committee: 2009 – 2012

  • European College of Neuropsychopharmacology ECNP, ECNP Award Committee: since 2017

  • EMBO – European Molecular Biology Organisation, Elected Member: since 2017

  • Univ. of Milano – Delegate Vice-Rector of Working Group Horizon 2020, 2012 – 2013

  • Univ. of Milano – National Coordinator Working Group CRUI H2020, 2012

  • Univ. of Milano – delegate at “The League of European Research Universities” (LERU), since 2015

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