Short CV/Education and training

  • Since 2017
    Professor of Structural Biology, Uppsala University, Sweden

  • 2014 – 2016
    Associate Professor of Structural Biology, Uppsala University, Sweden

  • 2014
    Biophysical Sciences Institute Fellow, Durham University, UK

  • 2011 – 2014
    Assistant Professor of Computational and Systems Biology, Uppsala University, Sweden

  • 2007 – 2010
    Postdoctoral Researcher, University of Southern California, USA

  • 2005 – 2007
    Postdoctoral Researcher, University of Vienna, Austria

  • 2002 – 2005
    PhD in Theoretical Organic Chemistry, University of Birmingham, UK

  • 1998 – 2002
    Master of Natural Sciences (Chemistry), University of Birmingham, UK

Selected publications

  • F. Duarte, J. Aqvist, N. H. Williams and S. C. L. Kamerlin. Resolving apparent conflicts between theoretical and experimental models of phosphate monoester hydrolysis. J. Am. Chem. Soc. 2015, 137, 1081.

  • P. Bauer, B. A. Amrein, F. Duarte, A. J. Carlsson, A. Naworyta, S. Mowbray, M. Widersten and S. C. L. Kamerlin. Expanding the catalytic triad in epoxide hydrolases and related enzymes. ACS Catal. 2015, 5, 5702.

  • A. Barrozo, F. Duarte, P. Bauer, A. T. P. Carvalho and S. C. L. Kamerlin. Cooperative electrostatic interactions drive functional evolution in the alkaline phosphatase superfamily.

  • J. Åqvist and S. C. L. Kamerlin. Conserved motifs in different classes of GTPases dictate their specific modes of catalysis. ACS Catal. 2016, 6, 1737.

  • F. Duarte, A. Barrozo, J. Åqvist, N. H. Williams and S. C. L. Kamerlin. The competing mechanisms of phosphate monoester dianion hydrolysis. J. Am. Chem. Soc. 2016, 138, 10664.

  • M. Purg, A. Pabis, F. Baier, N. Tokuriki, C. Jackson and S. C. L. Kamerlin. Probing the mechanisms for the selectivity and promiscuity of methyl parathion hydrolase. Phil. Trans. R. Soc. A. 2016, 374, 20160150.

  • B. Amrein, F. Steffen-Munsberg, I. Szeler, M. Purg, Y. Kulkarni and S. C. L. Kamerlin. CADEE: Computer Aided Directed Evolution of Enzymes. IUCrJ 2017, 4, 20160150.

  • D. Blaha-Nelson, D. M. Krüger, K. Szeler, M. Ben-David and S. C. L. Kamerlin. Active site hydrophobicity and the convergent evolution of paraoxonase activity in structurally divergent enzymes: The case of serum paraoxonase 1. J. Am. Chem. Soc. 2017, 139, 1155.

  • V. A. Risso, S. Martinez Rodriguez, A. M. Candel, D. M. Krüger, D. Pantoja-Uceda, M. Ortega-Muñoz, F. Santoyo-Gonzalez, E. A. Gaucher, S. C. L. Kamerlin, M. Bruit, J. A. Gavira and J. M. Sanchez-Ruiz. De novo active sites for resurrected Precambrian enzymes. Nat. Commun. 2017, 8, 16113.

  • Y. Kulkarni, Q. Liao, D. Petrovic, D. M. Krüger, B. Strodel, T. Amyes, J. Richard and S. C. L. Kamerlin. Enzyme architecture: Modeling the operation of a hydrophobic clamp in catalysis by triosephosphate isomerase. J. Am. Chem. Soc. 2017, 139, 10514.



Complete list of publications

Selected projects

  • Harnessing Protoenzymes for Novel Catalytic Functions, ERC Starting Grant, 2012 – 2017

  • From Generalists to Specialists: Understanding Protein Evolution, Knut and Alice Wallenberg Foundation, Wallenberg Academy Fellowship, 2014 – 2019

  • Modeling Enzyme Activation by Ligand Binding Free Energy, Swedish Research Council, 2016 – 2020

  • Generating and Understanding De Novo Enzyme Functionalities Using Ancestral Proteins as Scaffolds, HFSP Program Grant, 2017 – 2020

Membership in scientific bodies/juries

  • Fellow of the Royal Society of Chemistry (FRSC)

  • Member of the American Chemical Society

  • Member of the Biochemical Society

  • Member of the Swedish Chemical Society

  • Member of the International Society for Computational Biology

  • F1000Research Advisory Board Member in Biocatalysis

  • Member of the Swedish National Allocations Committee (SNAC) for Supercomputing Resources

  • Former Chair of the Young Academy of Europe (2014-2015)

  • Regular reviewer and panelist for national and international funding agencies, leading journals (>130 manuscripts for >40 journals since 2011), recruitment evaluation and doctoral committees.

  • >60 invited lectures at universities, research institutions and major conferences, including several keynote/plenary lectures.

Media coverage

  • Full list of interviews and articles about my research and/or science policy: https://kamerlinlab.com/media/

  • Video interviews: https://kamerlinlab.com/video-interviews/

Soft Skills/Other activities and achievements

Additional interests

  • Extensively active in high-level science policy, in particular issues related to young researchers, research excellence, as well as Open Science policy.


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