Short CV/Education and training

Education

  • 1988
    Master degree in Molecular Biology, Odense University

  • 1992
    PhD degree in Biochemistry, Odense University

Professional experience

  • 1992 – 1995
    Post doc at Dept. Biochemistry and Dept. Molecular Biology, Odense University

  • 1995 – 1996
    Post doc in Prof. M. Daniel Lane's lab, Johns Hopkins University, Baltimore, USA

  • 1996 – 1999
    Assistant Professor Dept. Molecular Biology, Odense University

  • 1999 – 2008
    Associate Professor Dept. Biochemistry and Molecular Biology, SDU

  • Since 2008
    Professor Dept. Biochemistry and Molecular Biology, SDU

Selected publications

  • R. Siersbæk, R. Nielsen, S. John, M.-H. Sung, S. Baek, A. Loft, G. L. Hager¤, S. Mandrup¤ (2011) Extensive chromatin remodeling and establishment of transcription factor ‘hotspots’ during early adipogenesis. EMBO J 30, 1459-72

  • M. Børgesen, T. Å. Pedersen, S. vanHeeringen, B. Gross, Hagenbeek, C. Bindesbøll, S. Caron, F. Lalloyer, K. Steffensen, H. Nebb, J.-Å. Gustafsson, H. Stunnenberg, B. Staels, S. Mandrup (2012) Genome-wide profiling of LXR, RXR and PPARα in mouse liver reveals extensive sharing of binding sites. Mol. Cell. Biol. 32, 852-867.

  • M.S. Siersbæk*, A. Loft*, M. M. Aagaard*, R. Nielsen, S. F. Schmidt, N. Petrovic, J. Nedergaard, S. Mandrup (2012) Genome-wide profiling of PPARγ in primary epididymal, inguinal and brown adipocytes reveals depot-selective binding correlated with gene expression. Mol. Cell Biol. 32, 3452–3463.

  • D. Neess, S. Bek, A.-B. Marcher, M. Bloksgaard, N. Færgeman, S. Mandrup (2013) Delayed hepatic adaptation to weaning in ACBP-/- mice is caused by disruption of the epidermal barrier. Cell Reports 5, 1403-1412.

  • M.S. Madsen, R. Siersbæk, M. Børgesen, R. Nielsen, S. Mandrup (2014) Peroxisome proliferator activated receptor γ and C/EBPα synergistically activate key metabolic adipocyte genes by assisted loading. Mol. Cell. Biol. 34, 939-954.

  • R. Siersbæk, S. Baek, A. Rabiee, R. Nielsen, S. Traynor, N. Clark, A. Sandelin, O.N. Jensen, M.-H. Sung, G.L. Hager, S. Mandrup (2014) Molecular architecture of transcription factor hotspots in early adipogenesis. Cell Reports, 7, 1434–1442.

  • R. Siersbæk, A. Rabiee, R. Nielsen, S. Sidoli, A. Loft, L.L.C. Poulsen, A. Rogowska-Wrzesinska, O.N. Jensen, S. Mandrup (2014) Transcription factor cooperativity in early adipogenic hotspots and super-enhancers. Cell Reports, 7, 1443–1455.

  • A. Loft, I. Forss*, M.S. Siersbæk*, S.F. Schmidt, A.-S. B. Larsen, J.G.S. Madsen, D. Pisani, R. Nielsen, M.M. Aagaard. A. Mathison, M.J. Neville, R. Urrutia, F. Karpe, E.-Z. Amri, S. Mandrup (2015) Browning of human adipocytes requires KLF11 and reprogramming of PPARγ super-enhancers. Genes & Dev. 29, 7-22.

  • S.F. Schmidt*, B.D. Larsen*, A. Loft, R. Nielsen, J.G.S. Madsen, S. Mandrup (2015) Acute TNF-induced repression of cell identity genes is mediated by NFκB-directed redistribution of cofactors from super-enhancers. Genome Res. 25, 1281-1294.

  • S.F. Schmidt*, J.G.S. Madsen*, K. Østerli, L.L.C. Poulsen, Sofia Salö, M. Børgesen, A. Loft, R. Nielsen, J.J.Holst, Louise T. Dalgaard, S. Mandrup (2016) Integrative genomics outlines a biphasic glucose response and a ChREBP-RORγ axis regulating proliferation in β-cells. Cell Reports 16, 2359-2372.

  • R. Siersbæk*, J.G.S. Madsen*, B.M. Javierre*, R. Nielsen*, E.K. Bagge, J. Cairns, S.W. Wingett, S. Traynor, M. Spivakov, P. Fraser¤, S. Mandrup¤ (2017) Dynamic rewiring of promoter-anchored chromatin loops during adipocyte differentiation. Mol. Cell 66, 420-435.



Complete list of publications

Selected projects

  • Susanne Mandrup is Director of the Center of Excellence in Functional Genomics and Tissue Plasticity (https://www.sdu.dk/en/atlas) and founder and head the Functional Genomics and Metabolism Research Unit (www.sdu.dk/bmb/functionalgenomics). Her own group (http://www.sdu.dk/mandrupgroup) focuses on understanding the transcriptional network regulating lineage determination and differentiation of adipocyte progenitors and the functioning and plasticity of cells in the adipose tissue and endocrine pancreas. The group combines genome-wide studies with detailed molecular analyses in cell culture and analyses of specific cell types in mouse models.

    International research consortia

Membership in scientific bodies/juries

  • 2000 – 2005 Executive board of the Danish Society for Biochemistry and Molecular Biology

    2003 – 2012 Co-founder and member of the executive board of the Danish PhD school of Metabolism

    2005 – 2010 Danish Natural Science Research Council

    2007 – 2014 Award Committee for the European Lipid Science Award

    2008 – 2016 National Bibliometric Group for Molecular Biology, Cell Biology and Biotechnology

    2009 – 2016 Medical and Natural Science Committee, the Novo Nordisk Foundation

    2012 – 2017 Member of the Council and the Research Committee of the Danish Diabetes Academy

    2013 – 2014 ERC LS2 Starting Grant panel

    2015- Chair of ERC LS2 Consolidator Grant panel

    2016 - Head of Functional Genomics and Metabolism Research Unit, SDU

    2017- Chair of Committee on Bioscience and Basic Biomedicine, the Novo Nordisk Foundation

    2017- Committee on International Research Leader Grants, the Novo Nordisk Foundation

    2018- Committee on Young Investigator Grants, Villum Foundation

Editorial and Advisory Boards

  • Editorial Board of Molecular and Cellular Biology, since 2013

  • Editorial Board of Molecular Endocrinology, since 2013

  • Scientific Advisory Board of the European Genomics Institute for Diabetes, Lille, France, since 2012

  • Editorial Board of Trends in Endocrinology and Metabolism, since 2011

  • Editorial Board of Cell Reports, since 2011

Other appointments

  • ERC panel member, since 2013, panel chair of LS2 CoG panel, since 2015

  • Member of the Council, the Research Committee and the Educational Committee of the Danish Diabetes Academy, since 2012

  • The Medical and Natural Science Committee of the Novo Nordisk Foundation, since 2009

  • National Bibliometric Group for Molecular Biology, Cell Biology and Biotechnology, since 2008

  • The Danish Natural Science Research Council, 2005 – 2010

  • Coordinator of the EU FP6 project X-TRA-NET, 2005 – 2009

  • Co-founder and member of the executive board of the Danish PhD school of Metabolism, 2003 – 2012

  • Executive board of the Danish Society for Biochemistry and Molecular Biology, 2000 – 2005

Additional qualifications

  • Educational course for assistant professors ('Adjunktpædagogikum'), 1997

  • Course in research management taught by Copenhagen Business School, 2006 – 2007

  • Invited speaker at >47 major international meetings and >40 host international institutions since 2007 in the field of transcriptional regulation, lipid metabolism and fat cell differentiation and function.

  • Organizer of 10 major international meetings since 2010


Soft Skills/Other activities and achievements

Soft Skills

  • Maternity leave 6 months in 1989 – 1990 and 6 months in 1992 – 1993


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