Short CV/Education and training

  • 1951
    born in Athens, Greece.

  • 1956 – 1960
    primary school England.

  • 1960 – 1968
    education Sweden, with Swedish "studentexamen"

  • 1968 – 1974
    Medical studies Karolinska Institutet

  • 1974
    MD, Karolinska Instituet

  • 1978
    Registered medical doctor after internship

  • 1980
    PhD Karolinska Institutet with Prof George Klein as supervisor

  • 1982
    Ass. professor Karolinska Institutet

  • 1987 – 1989
    Post doc at the National Institute for Medical Research, Mill Hill, London UK

  • 1991
    Specialist in clinical virology

  • 1995
    Specialist in clinical immunology

  • 1999
    6 year research position from the Swedish Cancer Foundation

  • since 2000
    Professor in Tumour virology, Dept of Oncology-Pathology, Karolinska Institutet

  • 2002 – 2011
    Head of the Dept of Oncology-Pathology, Karolinska Institutet

Selected publications

  • Mellin H, Dahlgren L, Munck-Wikland E, Lindholm J, Rabbani H, Kalantari M, Dalianis T.Human papillomavirus type 16 is episomal and a high viral load may be correlated to better prognosis in tonsillar cancer. Int J Cancer. 2002 Nov 10;102(2):152-8.

  • Dahlgren L, Mellin H, Wangsa D, Heselmeyer-Haddad K, Björnestål L, Lindholm J, Munck-Wikland E, Auer G, Ried T, Dalianis T. Comparative genomic hybridization analysis of tonsillar cancer reveals a different pattern of genomic imbalances in human papillomavirus (HPV) positive and negative tumors. Int J Cancer. 2003;107,244-249.

  • Giraud G, Bogdanovic G, Priftakis P, Remberger M, Svahn BM, Ringden O, Winiarski J, Ljungman P, Dalianis T. Hemorrhagic cystitis and BK-viruria are less common in allogeneic hematopoietic stem cell transplanted patients receiving reduced conditioning than in patients receiving full conditioning. Hematologica. 2006;91:401-404.

  • Allander T, Andreasson K, Gupta S, Bjerkner A, Bogdanovic G, Persson MAA, Dalianis T, Ramqvist T, and Larsson B.: Identification of a third human polyomavirus. J. Virol. 81(8):4130-4136, 2007.

  • Lindquist D, Romanitan M, Hammarstedt L, Näsman A, Dahlstrand H, Lindholm J, Onelöv L, Ramqvist T, Ye W, Munck-Wikland E, and Dalianis T. Presence of human papillomvavirus (HPV) in tonsillar cancer is a favourable prognostic factor and expression. Molecular Oncology, :350-355, 2007.

  • Näsman A, Attner P, Hammarstedt L, Du J, Eriksson M, Giraud G, Ährlund-Richter S, Marklund L, Romanitan M, Lindquist D, Ramqvist R, Lindholm J, Sparén P, Ye W, Dahlstrand H, Munck-Wikland E, and Dalianis T.: incidence of human papillomavirus (HPV) positive tonsillar carcinoma: an epidemic of viral induced carcinoma? Int. J. Cancer, 15;125(2):362-6, 2009.

  • Du J, Nordfors C, Ährlund-Richter A, Sobkowiak M, Romanitan M, Anderson S, Ramqvist T and Dalianis T: Prevalence of human papillomavirus infection among youth, Sweden. Emerging Inf Diseases 18(9) 1468-1471, 2012

  • Näsman A, Andersson E, Marklund L, Tertipis N, Hammarstedt-Nordenwall L, Nyberg T, Munck-Wikland E, Masucci Gv, Ramqvist T Dalianis T.: HLA class I and II expression in oropharyngeal squamous cell carcinoma in relation to tumor HPV status and clinical outcome. PlosOne Oct 10;8(10):e77025. doi: 10.1371/journal.pone.0077025. 2013

  • Näsman A, Nordfors C, Grün N, Munck-Wikland E, Ramqvist T, Marklund L, Lindquist D, Dalianis T. Absent Weak CD44 intensity and positive human papillomavirus(HPV) status in oropharyngeal squamous cell carcinoma indicates a very high survival. Cancer Medicine 2013 2(4)507-18.

  • Nordfors C, Grün N, Tertipis N, Ahrlund-Richter A, Haeggblom L, Sivars L, Du J, Nyberg T, Marklund L, Munck-Wikland E, Näsman A, Ramqvist T, Dalianis T.: CD8+ and CD4+ tumour infiltrating lymphocytes in relation to human papillomavirus status and clinical outcome in tonsillar and base of tongue squamous cell carcinoma.Eur J Cancer. 2013 Apr 6. doi:pii: S0959-8049(13)00222-0. 10.1016/j.ejca.2013.03.019. [Epub ahead of print]


Selected projects

A short description of the research activities:

  • General aims. A. To study a human papillomaviruses (HPyV) and specific markers for tailored therapy of head neck cancer (HNSCC); B. To study the newly detected human polyomaviruses (HPyV) especially in cancer and disease.

  • Background and previous results. HPV and HPyV are small DNA viruses, of which some types or species are potentially oncogenic. Best known is that HPV causes cervical cancer. However HPV is besides smoking and alcohol, also associated to oropharyngeal cancer, where tonsillar and base of tongue cancer dominate and we and others have shown that HPV-positive tonsillar and base of tongue cancer have a much better survival than the corresponding HPV-negative cancer and head neck cancer in genereal (80% vs. 40% 5-year disease specific survival). In addition, we were first to show that the incidence of HPV-positive tonsillar and base of tongue cancer has increased the past decades. From 2007, 12 new HPyVs have been detected and we were involved in disclosing the first (KIPyV) of these HPyVs.

    Preliminary results and research plan. I. Studies of HPV in HNSCC. Due to its poor prognosis, HNSCC therapy includes chemotherapy and intensified radiotherapy (RT), with many more side effects compared to conventional RT given before. This is unnecessary for 80% of patients with HPV-positive tumors doing well with conventional RT. However, before de-escalating therapy, it is important to find markers that with HPV can better predict a favorable response to conventional treatment. We have identified such markers, e.g. HLA class I, CD44, LRIG, CD8 tumor infiltrating lymphocyte counts that each or together identify 20-30% of patients with 90-95% probability for complete response. Now we want to combine old and newer markers in the pipeline, understand their mechanism of action to identify virtually all patients with a very good outcome in order to safely start prospective randomized trials with less therapy. II. Studies of HPyV. From 2007, 10 new HPyVs have been identified. We want to study their presence in cancer and disease.

Membership in scientific bodies/juries

  • Swedish medical society

  • Swedish society for microbiology

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