Short CV/Education and training

  • 1993
    Higher Scientific Officer (HSO), Rowett Research Institute, Aberdeen, U.K.

  • 1994 – 1996
    European Union Biotech Fellow (Dir: Professor A. Azzi) Institute of Biochemistry and Molecular Biology, University of Bern, Switzerland

  • 1996 – 1998
    Parker B. Francis Research Fellow (Dir: Professor B.A. Freeman), Department of Anesthesiology, Univ. of Alabama at Birmingham, Alabama, USA

  • 1999 – 2002
    Wellcome Trust Research Career Development Fellow, Depts of Pharmacology & Medical Biochemistry, University of Wales College of Medicine, Cardiff, UK

  • 2002 – 2005
    Wellcome Trust Senior Lecturer (University Award), Dept of Medical Biochemistry, University of Wales College of Medicine, Cardiff, UK

  • 2005 – 2008
    Reader, Dept of Medical Biochemistry, Cardiff University, UK

  • Since 2008
    Professor, Dept of Medical Biochemistry, Cardiff University, UK

  • 2012
    Deputy Dean of Research, School of Medicine, Cardiff University, UK

  • Since 2012
    Dean of Research (Acting), School of Medicine

Selected publications

  • O'Donnell, VB, Murphy, RC, Watson, SP (2014) Platelet Lipidomics: a modern day perspective on lipid discovery and characterization in platelets. Circ Res (invited review, thematic series on platelets, in press).

  • Fielding, CA., Jones, GW., McLoughlin, RM., McLeod, L., Williams, AS., Lambie, M., Foster,TL., Liao, C., Hammond, VJ., Rice, CM., Greenhill, CJ., Colmont, CS., Hams, E., Coles, BA., Kift-Morgan, A., Craig, KJ., Williams, JD., Williams, GT., Davies, SJ., O'Donnell, VB., Taylor, PR., Jenkins, BJ., Topley, N. and Jones, SA. (2014) IL-6 Signaling Drives Fibrosis in Unresolved Inflammation Immunity (in press).

  • Thomas, CP, Clark, SR, Hammond, VJ, Aldrovandi, M, Collins, PW, O'Donnell, VB (2014) "A protocol for identification and quantitation of aminophospholipid molecular species on the cell surface using mass spectrometry". Nature Protocols 9, 51-63.

  • Aldrovandi, M, Hammond, VJ, Podmore, H, Hornshaw, M, Clark, SR, Marnett, LJ, Slatter, DA, Murphy, RC, Collins, PW, and O'Donnell, VB (2013) Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation. J Lipid Res 54, 3085-3097.

  • Clark, SR, Thomas, CP, Hammond, VJ, Aldrovandi, M, Wilkinson, GW, Hart, KW, Murphy, RC, Collins, PW, O'Donnell, VB (2013). "Characterization of platelet aminophospholipid externalization reveals fatty acids as molecular determinants that regulate coagulation". Proc Natl Acad Sci USA, 110, 5875-5880.

  • Bonilla, L, O'Donnell, VB, Clark, H, Rubbo, H & Trostchansky, A. (2013) "Regulation of protein kinase C by nitroarachidonic acid: impact on platelet activation" Archives Biochem Biophys 533, 55-61.

  • Aldrovandi, M & O'Donnell, VB (2013) "Oxidized lipids and vascular inflammation" Current Atherosclerosis Reports 15, 323.

  • Thomas, CP, Boeglin, WE, Garcia-Diaz, Y, O'Donnell, VB, Brash, AR. (2013) Steric analysis of epoxyalcohol and trihydroxy derivatives of 9-hydroperoxy-linoleic acid from hematin and enzymatic synthesis. Chemistry and Physics of Lipids 167-168C:21-32.

  • Hammond VJ, Morgan, AH, Thomas, CP, Brown, S, Freeman, BA, Lloyd, CM, Davies, J, Bush, A, Levonen, AL, Kansanen, E, Villacorta, L, Chen, YE, Porter, N, Garcia Diaz, YM, Schopfer, FJ & O'Donnell, VB (2012) Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis and activate peroxisome proliferator-activated receptor-?. J Biol Chem 287, 41651-41666.

  • O'Donnell, VB, Murphy, RC. New families of bioactive oxidized phospholipids generated by immune cells: identification and signaling actions. (2012) Blood 120, 1985-1992.



Complete list of publications

Selected projects

  • European Research Council Advanced Grant (2014 – 2019) LipidArrays. 2.97M V O'Donnell (PI), J Williams, S Allen, F Geissman, P Taylor, S Humphries (collaborators).

  • MRC Project Grant (2013 – 2016). "Defining the role of peritoneal dendritic cells in tissue specific immunity and the clinical application of peritoneal dialysis" £559,777 (100% of fEC). P. Taylor (lead), N. Topley, S. Jones and V. O'Donnell (co-investigators).

  • Elucidating functional brain imaging biomarkers for risk genes implicated in Alzheimer's disease, K Graham £49K, Oct 2013 – Sept 2014, ISSF (NISHR/Wellcome).

  • ISSF NISCHR/Wellcome Trust Fellowship, CP Thomas (Fellow), VB O'Donnell (Sponsor), £50K, July 2013 – June 2014.

  • British Heart Foundation Programme Grant "Characterisation of novel endogenous mediators of thrombosis" VB O'Donnell (PI), P Collins, K Channon, R Murphy, M Crump (Co-investigators). May 2013 – Apr 2018, £827,144.

  • Arthritis Research UK Programme Grant (19796)- Can altered cytokine signaling predict the course of inflammatory arthritis? £499,999. To S.A. Jones (PI), E. Choy, V.B. O'Donnell, A.S. Williams (co-investigators), 04/12 – 04/15.

  • British Heart Foundation Clinical Research Training Fellowship. "Predicting excess bleeding due to haemostatic failure following cardiopulmonary bypass surgery" £185 878. BHF FS/11/42/28753. C Percy (Fellow). Supervisors: P Collins, V O'Donnell, J Hall.

  • Wellcome Trust Programme Grant "Chemical and biological actions of esterified eicosanoids generated by human immune cells: Understanding membrane signaling actions of novel lipid families" £1,202,625 Sept 2011-Aug 2016. V. O'Donnell (PI), I Sabroe, S Jones, P Taylor, P Collins.

  • National Institutes of Health USA RO1 AI040600 "Amplification of IL-4Ralpha signaling pathways in human airways through 15-L01" $1.2M of which $27K per year comes to Cardiff. S Wenzel (PI), M Rosner, VB O'Donnell (Consultant), July 2010 – June 2015.

Membership in scientific bodies/juries

  • Fellow of the Society of Biology

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News

  1. The language of lipids

    In this AcademiaNet interview, Professor O'Donnell tells us about her research on the relationship between lipids, aspirin and inflammation.