Short CV/Education and training

  • 1984 – 1988
    BSc student at Peking University, China

  • 1989 – 1995
    PhD student at Stony Brook University, New York, USA

  • 1995 – 1997
    Howard Hughes Medical Institute postdoctoral fellow, Harvard University (laboratory of Don Wiley), Boston, USA

  • 1997 – 2000
    Postdoctoral Research fellow, Cancer Research UK, London

  • 2001 – 2005
    Lecturer, Imperial College London, UK

  • 2005 – 2008
    Reader in Molecular Structure and Function, Imperial College London, UK

  • Since 2007
    Visiting professor, College of Life Sciences, Peking University, China

  • Since 2008
    Professor of Macromolecular Structure and Function, Imperial College London

  • Since 2011
    Director, Centre for Structural Biology, Imperial College London

Selected publications

  • Saravanan M, Wuerges J, Bose D, McCormack EA, Cook NJ, Zhang X and Wigley DB (2012) "Interactions between the nucleosome histone core and Arp8 in the INO80 Chromatin Remodelling Complex". Proc Natl Acad Sci USA, 109:20883-8.

  • Bebeacua C, Forster A, McKeown C, Meyer H, Zhang X, Freemont P (2012). "Distinct conformations of the p97-Ufd1-Npl4 complex revealed by electron cryo-microscopy". Proc. Natl Acad Sci USA. 109:1098-103.

  • Klein BJ, Bose D, Baker KJ, Yusoff ZM, Zhang X, Murakami KS. (2011). "The RNA polymerase and transcription elongation factor Spt4/5 complex structure". Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):546-50.

  • Lu D, Fillet S, Meng C, Alguel Y, Kloppsteck P, Bergeron J, Krell T, Gallegos MT, Ramos J, Zhang X (2010). "Crystal Structure of TtgV in complex with its DNA operator reveals a general model for cooperative DNA binding of tetrameric gene regulators". Genes Dev. 24(22):2556-65.

  • Bose D, Pape T, Burrows PC, Rappas M, Wigneshweraraj SR, Buck M, Zhang X. (2008). "Organisation of an activator bound RNA polymerase holoenzyme". Molecular Cell, 32(3):337-46.

  • Zhang X, Wigley DB. (2008). "The 'glutamate switch' provides a link between ATPase activity and ligand binding in AAA+ proteins". Nat Struct Mol Biol. 15(11):1223-7.

  • Pye V., Beuron F., Keetch C., Mckeown C., Robinson CV., Zhang X., and Freemont P. (2007) "The p97-Ufd1-Npl4 Complex: First Sructural Insights". Proc. Natl. Acad Sci USA. 104(2):467-72.

  • Rappas M., Schumacher J., Beuron F., Niwa H., Bordes P., Wigneshweraraj SR., Keetch CA, Robinson CV., Buck M., and Zhang X. (2005). "Structural Insights into the Activity of Transcriptional Enhancer-Binding Protein". Science, 307:1972-5.

  • Dreveny, I., Kondo, H., Shaw, T., Uchiyama, K., Zhang, X., and Freemont, P.S..(2004) "Structural Basis of the interaction between the AAA ATPase p97/VCP and its adaptor protein p47" EMBO J. 23: 1030-1039 (Joint Corresponding author).

  • Zhang X, Shaw A, Bates P, Newman R, Gowen B, Orlova E, Gorman M, Kondo H, Dokurno P, Lally J, Leonard G, Meyer H, van Heel M and Freemont PS, (2000) "Structure of the AAA ATPase p97" Molecular Cell, 6, 1473-1484 (2000).

  • Rosenthal PB, Zhang X, Formanowski F, Fitz W, Wong CH, Meier-Ewert H, Skehel JJ, Wiley DC (1998) "Structure of the haemagglutinin-esterase-fusion glycoprotein of influenza C virus". Nature 396: 92-96.

  • Zhang X, Morera S, Bates PA, Whitehead P, Coffer A, Hainbucher K, Nash RA, Steinberg MJE, Lindahl T, Freemont PS, (1998) "Structure of an XRCC1 BRCT domain: a new protein-protein interaction module". EMBO J. 17:6404-6411.

  • Ade H, Zhang X, Cameron S, Costello C, Kirz J, and Williams S. (1992) "Chemical contrast in x-ray microscopy and spatially resolved XANES spectroscopy of organic specimens". Science, 258, pp. 927-975.



Complete list of publications

Selected projects

  • Structures and mechanisms of key components in DNA damage response

  • Structures and mechanisms of AAA ATPase p97

  • Structures and mechanisms of transcription regulation

Membership in scientific bodies/juries

  • Elected President of Peking University UK Alumni Association, 2013

  • Outstanding Alumni of Peking University in the UK, 2013

  • Wellcome Trust Peer Review College Member, since 2012

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