Cell Biology, Cellular and Molecular Neuroscience, Vascular Biology, Tumour Biology

Neurovascular link, Neurodevelopment, Developmental and pathological angiogenesis, Glioma invasion

Cell Biology, Cellular signaling, Cancer biology, Cancer therapy

Molecular mechanisms of cancer cell resistance to therapy, Autophagy, Cell death pathways, Endoplasmic reticulum stress, Membrane contact sites, Immunogenic cell death, Oxidative stress, Immunotherapy, Vascular biology and (lymph)angiogenesis

Public Health

Health Policy and Systems Health Financing, Universal Health Coverage Systems Thinking Maternal and Newborn Health

Academic Medicine

Understanding ageing from a lifecourse perspective to optimise the health and healthcare of older people Integrating clinical, epidemiological, basic and social science to allow an interdisciplinary approach to studying sarcopenia and frailty Capacity building in academic geriatric medicine and interdisciplnary gerontology.

Role of astrocytes in brain function

Role of astrocytes in brain development and function: Synaptic development Synaptic plasticity and learning Synaptic repair in disease

Translational research, invasion, metastasis, disseminated tumor cells, transcription, tumor-associated proteolysis, targeted therapy, micro-RNAs, molecular staging of cancer

Brain research

Multi-level brain organisation, Human brain mapping, Big data analytics, Atlas, Language, Aging and disease, Image analysis, Ethics

Neurophysiology (synaptic physiology)

Epilepsy (development)

Internal medicine, Hematology - hemostasis, Clinical laboratory sciences - hematology

Pathophysiology of hemostasis and thrombosis Clinical research in the field of hemostasis and thrombosis

Obesity, Diabetes, Immunology

In the Aouadi lab we investigate the mechanisms involved in the development of diabetes and liver disease in obese patients. In a healthy individual, the pancreas produces insulin, a hormone that regulates the amount of glucose in the blood after a meal. However, especially in obese patients, a condition termed insulin resistance occurs before overt diabetes. This is a condition in which the body cannot respond to insulin and therefore produces high levels of insulin to compensate. Despite this compensation, glucose is still not properly metabolised. For instance, the adipose tissue cannot properly take up glucose and store it in forms of fat, which results in lipid accumulation in other organs, such as the liver. Fat accumulation in the liver is toxic and can lead to a disease called Non-Alcoholic SteatoHepatitis (NASH). NASH is projected to become the leading cause of liver related morbidity and mortality within 20 years, and the most common indication for liver transplantation in the next few years. In spite of its high prevalence and potential life-threatening effects, no approved treatments are currently available due to a lack of understanding of the pathogenesis. Epidemiological studies show that individuals with obesity and insulin resistance are at the greatest risk of developing NASH. However, the underlying mechanisms causing liver disease in individuals with metabolic disorders such as obesity and insulin resistance remain unknown. Our lab has discovered that macrophages in the liver and adipose tissue are crucial in the development of metabolic dysfunction in these tissues independently of their inflammatory profile. Our lab takes advantage of sophisticated methods to investigate the multiple roles of macrophages and their function in obesity-associated metabolic dysfunction.

Neuroscience

Neuronal circuits, motor behavior, genetics

Endocrinology

Steroid endocrinology, steroid metabolomics, androgen excess and deficiency, pre-receptor steroid regulation, systems biology, adrenal and gonadal disorders

Biochemistry, Molecular and Cell Biology

Mitochondrial Pathophysiology Intracellular Signaling Intercellular Communication Neuroenergetics Neurodegeneration Hypoxia/Ischemia Neuroprotection

Role of TGFbeta signalling in cardiovascular development and heart repair

Role of endoglin in cardiovascular development and disease. How endoglin modulates angiogenesis in coronary vessel development and in heart repair. How TGFbeta signalling regulates angiogenesis. Characterising molecular and cellular defects in Hereditary Haemorrhagic Telangiectasia to inform development of patient therapies.

Molecular and cellular neurobiology

Cortical development Cortical injury

Molecular Evolution, Evolution of antibiotic resistance

I'm interested in the ancient evolutionary origins of core cellular processes. My work is also concerned with how bacteria have adapted components of these core processes in their evolution of antibiotic resistance.

Bioinformatics

Protein sequence analysis, with particular emphasis on G protein-coupled receptors

Molecular Biology, Cell Biology, Biochemistry, Biology

DNA topoisomerase II

Meiosis, chromatin structure regulation, spermatogenesis, fertility

Chromosome pairing, chromatin reorganisation during gametogenesis, the impact of the paternal epigenome on early embryo development

Medical genetics, Pediatric genetic diseases, Developmental biology

Ciliopathies, Primary cilium biology, Genetic and phenotypic variability in Mendelian disorders

Molecular Medicine

Molecular Medicine, RNA, Neuroscience

Chromatin Biology

DNA topology, DNA topoisomerases, transcription, chromatin, non-B DNA structures, genome architecture

Ophthalmology and optometry; rare eye diseases; ocular inflammations and infections; uveitis

Ocular immunology/infectious diseases Geographical ophthalmology

Systemic neuroscience

Our question: How is information processed and encoded in the brain's neural networks in order to realize learning, memory and behaviour? This is one of the most fundamental questions of the modern life sciences, and one that my working group and I would like to answer. Our goals: 1. To determine the cellular and synaptic mechanisms underlying communication between nerve cells in the brain. 2. To investigate how those brain rhythms are generated which are assumed to serve the purpose of processing and encoding information. 3. To determine the rules governing synaptic plasticity in nerve cells as a basis of information storage. 4. To clarify the role of the different types of nerve cells in behaviour and memory formation.

Biomedical engineering

Speech perception, auditory perception, hearing impairment, hearing aids, cochlear implants, audiovisual integration, auditory cognition, behavioral studies, aging

Motor cognition Social intentionality, action and intention representation Mechanisms underlying the ability to create a shared world Temporal cognition and role of temporal mechanisms in object processing Kinematics, Neuroimaging (fMRI)

Anesthesiology, Perioperative Medicine, Immunopathology

Our research aims at basic, translational and clinical research. There are two main topics: perioperative organ protection with the use of volatile anesthetics as well as nanomedicine. Organ protection - Acute lung injury: exploring protective signaling pathways - Ischemia-reperfusion injury in lung and liver - Cancer research: defining the impact of general anesthetics on tumor cells and tumor progression - Repair mechanisms in lung and liver: elucidation of the impact of hypoxia - Development and testing of new drugs with protective character Nanomedicine - Blood cell elimination with the help of magnetic nanoparticles - Elimination of cancer cells using nanoparticles

Protein biochemistry, Malaria, Structural biology, Drug development

Biochemistry of redox metabolism, Rational development of drugs to fight malaria and tumour-based diseases, Parasite-host interactions, Redox proteins, Selenoproteins

Molecular and cellular biology, Neurobiology, Genetic disorders

Development and disorders of the brain, particularly of the cerebellum Neurodegeneration Cerebellar ataxia Autism

Cancer BiologyCellular and Molecular BiologyMetabolism

Energy Metabolism Glycation and Oxidation Stress Metastasis Development Resistance to Cancer Therapy

Stem Cells and Skeletal Ageing

Animal welfare and 3Rs, drug development, tissue engineering, bone analysis

Neuroscience, Neurophysiology and brain research, Brain research

I'm interested in investigating the cellular mechanisms and the circuits underlying behavioural deficits in Autism Spectrum Disorders

Nanomedicine, Inflammatory Bowel Diseases, Type 2 Diabetes Mellitus, Non-alcoholic fatty liver disease

My main research interests are the investigation of the oral drug delivery route (especially focused on the oral delivery of biologics) and the interaction of the drug delivery system with the gastrointestinal epithelium. My research in mainly focused on the development of innovative oral drug delivery systems for the treatment of gastrointestinal diseases.

Pharmacology, bio-engineering, imaging, biotechnology, Biology, Neurosciences, Cell Biology, Cellular and Molecular Neuroscience, Vascular Biology, Neurobiology

Brain ischemia, stroke, brain tumour, hypoxia, hypoxia-inducible factors, regeneration, neuroprotection, cell therapy, mesenchymal stem cell, imaging, therapeutic

Rheumatology

Osteoarthritis

Human genetics, molecular genetics

Genetic causes of alopecia and skin diseases

Infectious Diseases

Invasive fungal infections; Antifungals; Cryptococcal meningitis; Cryptococcus

Musculoskeletal diseases with special interest in osteoarthritis.

Clinical, epidemiological, and translational research into early recognition and treatment of osteoarthritis.

Biological psychiatry, depression, human genetics, the stress-hormone system

My main research interest is exploring the interaction between genetic and environmental factors in the development of psychiatric disorders, particularly anxiety disorders and depression. My research group uses endocrine, molecular genetic and psychometric methods to clarify these interrelations. A more precise knowledge of these interactions may make it possible to identify biologically distinct groups of patients and then to provide each group with more targeted, and thus better, treatment.

Virology, Molecular biology, Cell biology, Biochemistry

Infection and Replication of Retroviruses

Neurodegenerative disease, Biomarkers Huntington´s disease

Peripheral pathology in Huntington´s disease Energy metabolism Preclinical pharmacology

Specialisation in forensic anthropology, the legal determination of identity, human anatomy and research into child sexual exploitation

Research is in novel biometrics, forensic anthropology, identity and human anatomy

Development of neuronal diversity

Epidemiology and statistics

Epidemiology of cancer and radiation illnesses Research concentrations: biometric methods in epidemiology and epidemiological studies of radiation-induced tumours

Medical protein chemistry, Immunology

Immunology, the complement system, infections, cancer, autoimmune diseases, protein chemistry

Obesity, Endocrinology

Lipid implication in induction of insulin resistance, Obesity, Mass spectrometry

Public Health, Public Health Genomics, (Genetic) Epidemiology of cancer, Epidemiological Methods

Public health; cardiovascular epidemiology; genetic epidemiology of complex cardiovascular traits; arterial hypertension; chronic kidney disease.

Clinical cardiovascular research

Cognitive Neuroscience, Language, Brain Development, Educational neuroscience, Neuroimaging

Speech perception, Language development, Reading, Audiovisual integration, Dyslexia

Inflammation and cardiometabolic pathophysiology in obesity

Cardiometabolic disease is driven by inflammation, particularly in the adipose tissue. Inflammation consists of the initial acute phase, followed by a resolving phase. Importantly, the latter is regulated by specialized pro-resolving lipid mediators, e.g. the lipoxins, acting through defined receptors. ​Our research focus on the investigation of specialized pro-resolving lipid mediators, such as the lipoxins, and their ability to promote cardiometabolic health in obesity.

Neuroscience

Neuroscience, Signal Transduction, Systems Biology

Physiology of adipose tissue and obesity

Insulin resistance Inflammation Progenitor cells Angiogenesis

Regenerative Medicine, Tissue Engineering

Cardiovascular regeneration, cardiac tissue, heart valves, vessels

Epidemiology

1. Epidemiology of adverse pregnancy outcomes (preterm delivery, pre-eclampsia, recurrent pregnancy loss, post-partum depression), including genetic aspects 2. Epidemiology of cardiac and cardiovascular disease (ischemic heart disease, cardiomyopathy, sudden cardiac death) and renal disease, particularly familial and genetic aspects 3. Links between adverse pregnancy outcomes and cardiac/cardiovascular/renal disease

Academic field: History of science. Area of specialisation: The development of Babylonian astronomy and mathematics

Dermatology, dermatopathology

Tumour biology Immunology

Immunology

Infectious disease immunology Staphylococcus aureus Sepsis

Dermatology, molecular medicine

Biology and pathology of the skin/epithelia Genetic skin diseases Biology of the extracellular matrix Basement membranes

Immunology

Immune regulation mucosal immunity autoimmunity alveolar epithelium host-pathogen interaction infection and autoimmunity regulatory T cells immune modulation in the context of infections

Computational biology, Bioinformatics, Mathematical modelling, Genomics, Epigenetics, Trascriptomics

Computational: machine learning, agent-based modelling, omics biomarkers; Biology: cancer biology, tumour microenviroment, hypoxia; Omics: transcsriptomics, genomics, epigenetics, single-cell sequencing, spatial transcriptomics

Laboratory Medicine, Hematology/Oncology, Hemostaseology, Immunology

The role of chemokine receptors in tumor formation and in immunological processes: - processes of tumour cell transformation, angiogenesis and metastasis - influence of the microenvironment on tumor progression and chemotherapy resistance - tumor stem cells - migration and homoeostasis of immune cells

Memory, Addiction, PTSD, Cell Signalling, MAPK, Dopamine, Glutamate, fear, anxiety, amygdala, learning

My research focuses on understanding how fear memories are acquired and remembered. I propose a key role for the interaction of two neurotransmitters (dopamine and glutamate) and will investigate their potential involvement as key substrates of fear memories and anxiety. I combine behavioural, cellular and molecular analyses of the underlying mechanisms of memory. In this way, my aim is to find targets for pharmacotherapy to disrupt such memories specifically.

Geriatric epidemiology

The main focus of my scientific work since the early days has been to increase understanding of the complex healthcare needs of older adults with multiple chronic conditions (i.e. multimorbidity). The ultimate objective of my research career is to translate knowledge gained from epidemiological studies into improved healthcare delivery by developing future intervention programs aimed at reducing the adverse health consequences associated with multimorbidity and polypharmacy. This will be one of the critical public health challenges of the 21st century. During my Doctoral period (2008-2011) and part of my Postdoctoral period at the Aragon Health Sciences Institute in Spain (2012-2015), I studied the epidemiology of multimorbidity (e.g. patterns of diseases and geriatric conditions, polypharmacy patterns), and its impact on health systems (e.g. healthcare use, medication adherence, adverse drug events), and patients (e.g. obesity and weight loss, physical activity). I am also participating in a cluster randomized trial in young-old patients with multimorbidity and polypharmacy aimed at improving physician drug prescription in the Spanish primary care (https://clinicaltrials.gov/ct2/show/NCT02866799). Throughout my Postdoctoral period at the Aging Research Center of Karolinska Institutet (2015-present), I have initiated an innovative research approach that shifts from the traditional focus on single diseases towards multidimensional and longitudinal health trajectories. Thanks to a Starting Grant received from the Swedish Research Council (2017-2020), I will study the environmental, behavioural and biological determinants of such trajectories. We will also explore the interaction of these health pathways with the use of medical and social care services, as a means to move forward in supporting person-centred care (Grant from the Swedish Research Council for Health, Working Life and Welfare, 2018-2020).

Neuro-endocrine-immunology, Experimental rheumatology

Role of neuronal-like mechanisms used by non-neuronal cells to modulate inflammation, Dopaminergic pathways in rheumatic diseases, Stress-related effects on immune response, Neurotransmitter-immune cells interaction during aging, Sex-specific differences in the neurotransmitter-immune cells interaction

Immunology

Immunoregulation, autoimmune disease, tumor immunity

1. Science:Neuroscience, in particular systems neuroscience, computational neuroscience, neurotechnology, science and research management2. Career paths and decisions, career counseling, workshops and lectures3. Funding for research & development in academia & industry, grant counseling

Computational neuroscience Motor control Brain-machine interfaces Neurotechnology Novel therapies

Epigenetics

Neuroscience

Aging, Environmental and genetic influencing factors influencing variability of the aging brain, Brain structure, Functional brain networks, Brain connectivity

Neurobiology, development of the nervous system, formation of neuronal connectivity

Characterization of gene pathways controlling early steps of the formation of the nervous system Characterization of developmental programs reactivated during tumorigenesis

Blood coagulation disorders

Genetics and biochemistry of coagulation factor deficiencies, particularly factor V deficiency Familial thrombophilia, particularly APC resistance and protein S deficiency

Nanomaterials, Nanomedicine, Drug delivery, Stimuli-responsive nanoparticles, Tharanostc nanoparticles, Cancer, Extracellular vesicles, Synthesis of metal oxide, Inorganic materials, Surface properties, Surface functionalization, Bioconjugation

My main research interest is about theranostic nanomaterials, from wet chemical synthesis, chemical functionalization and physical-chemical characterization of metal oxide nanomaterials to drug delivery, stimuli-responsive activation, tumor cell targeting, and bio-imaging. Materials like zinc oxide, mesoporous silica, titania and metal (gold, silver) nanostructures are investigated in my research group. I'm also deeply focused on the extraction of extracellular vesicles and their re-engineering for advanced drug delivery and nanoimaging vehicles.

NeurologyNeuroscienceTranslational Medicine

The main goal of my research is to unravel pathophysiological mechanisms and therapeutic targets for basal ganglia disorders and other related brain diseases. To pursue this goal, my research group utilise several methodologies (physiology, biochemistry, histopathology, molecular biology, brain imaging, and behavioural neuroscience). We apply these methodologies to animal models of disease that we continuously develop and optimize. We pay great attention to verify the relevance of our experimental findings to the human diseases by using different types of biomarkers. I am particularly recognised for my work in the area of Parkinson’s disease (PD) and L-DOPA-induced dyskinesia (LID), for which we have developed experimental models and key pathophysiological notions that are widely accepted today. On a more general level, I am intrigued by the brain’s capacity for plasticity and repair and interested in harnessing and boosting it for therapeutic purposes. To achieve this goal, I would like to develop innovative treatments combining pharmacological and rehabilitative principles.

Tumour immunology

The innate immune response against cancer, natural killer cells and cancer

Cancer epidemiology and genetic epidemiology

Non-genetic and genetic determinants of cancer risk and prognosis, with a focus on breast cancer and colorectal cancer Prediction of risk and prognosis Non-genetic and genetic determinants of radiatherapy toxicity, with a focus on breast cancer

Global Health, Innovation and International Development, Research and Innovation Policy

I have a broad range of research interests in the area of research and innovation policy. In recent years I have led numerous studies in health innovation both in the context of industrially developing and developed countries. I am particularly interested in the ways in which public and private sectors interact in the innovation space.

Neurophysiology

Parkinson's disease, synaptic plasticity, novel treatment targets

Endocrinology and Diabetes

Diabetes insipidus, Copeptin, Stress hormones, e.g. corticosteroids as treatment for pneumonia and as prognostic biomarker in different disesaes

Immunology, Biochemistry

Immunoregulatory role of protease and protease inhibitors Autoinflammatory diseases Pathophysiology of body barriers

Vascular Physiology

Microvasculature Control of blood flow Cardiovascular and metabolic disease Developmental origins of health and disease

HIV/AIDS, abuse and child health

Large-scale longitudinal surveys Randomised controlled trials Quasi-experimental methods Working closely with policy-makers

Gene therapy, immunology, virology

Nutrition

nutrition, food, lifecycle, ageing, obesity, pregnancy

Immunology, Neuroimmunology, Pathology, Neuroscience

Immunology, Neuroinflammation, Leukocyte trafficking, Multiple Sclerosis, Alzheimer's disease, Epilepsy, Neurodegeneration, Systems Biology

Statistical Genetics

Statistical methodology for the analysis and interpretation of genetic data

Platelet biology

Providing mechanistic insight into the process of thrombus formation Characterising the vascular-directed effects of platelet-thrombi Effectively curtailing platelet activities in order to find new reference points for antithrombotic medication

cell biology

somatic cell reprogramming, tissue regeneration, stem cell biology, cell fusion, Wnt signaling

Gene expression/RNA processing/translation/mRNA/drug discovery/cancer biology/stem cell biology/immunity

Investigating mRNA cap function in mammals

perception/action psychology; decision-making; sports technology; immersive technologies; rehabilitation; movement disorders; TBI

Decision-making in sport Serious gaming Technology for Movement re-training and rehabilitation Parkinson's disease Sensory Cueing for Stroke rehabilitation Sports Related concussion

Veterinary medicine -> Clinical pathology -> Hemostasis and thrombosis.

Platelet pathophysiology in companion animal medicine Profiling of canine platelet protein secretion in the search for platelet biomarkers Assaying of platelet microparticles in dogs and cats Analytical assay validation Assay validation of diagnostic and research biomarkers

Reproductive Health

Studies have focused upon local uterine mechanisms involved in menstruation, implantation and pregnancy interruption. These studies address common processes in these pivotal reproductive events, including: injury and repair, the regulation and role of local inflammatory mediators and local immune-endocrine interactions. Data from these studies have made major contributions to understanding the local endometrial response to withdrawal of progesterone, both physiological and pharmacological. Specifically, study of the local effects of pharmacological steroid receptor modulation in uterine tissues has informed potential development of novel treatment strategies for problematic uterine bleeding and in the field of endometrial contraception. Our local clinical and laboratory science environment has permitted valuable productive collaboration with research teams working in inflammation research, (cardio)vascular biology and novel imaging.

Immunology

epithelial barrier microbiota parasite infection dendritic cell eosinophil gut

Haematology

Haematopoiesis, Single Cell Transcriptomics, Functional genomics, Zebrafish

Clinical Neurology, Neuroimmunology, Postgraduate Teaching in Clinical and Experimental Neurology, Clinical Studies

Cerebrovascular Diseases Multiple Sclerosis andNeuroimmunology Wilson's Disease Neurorehabilitation

Cancer Research, Tumour virology, with also clinical experience as an MD. in clinical virology, clinical immunology and especially transplantation immunology.

Cancer biology in general, tumour virology, and especially with regard to human papillomaviruses and human polyomaviruses and their association to cancer and disease, the latter especially in immunosuppressed patients.

Gene delivery technologies and retinal gene therapy

Gene delivery (Adeno-associated virus, nanoparticles) Gene therapy Optogenetics Retinal degeneration

Metabolic physiology, nutrition science

The structure and function of nutrient transport proteins, regulation of metabolism by nutrients at the level of the transcriptome, proteome and metabolome, nutrigenomics, nutrient-drug interactions.

immunology, Diabetology, Physiology

Immunology of diabetes, Autoimmunity, Type 1 diabetes, Immune tolerance, Humanized models

Empirical Labour Economics, Empirical Family Economics, Human Capital and Early Child Development, Gender Economics, Empirical Industrial Economics

Empirical Policy Evaluation Interdependence of the Family and the Labour Market Gender Economics Child Development Mental health, Subjective Well-being and Job Satisfaction Economic Uncertainty Poverty and Inequality Competition and Innovation

Medical genomics, Medical genetics, Human molecular genetics, Ophthalmic genetics, Developmental genetics

Medical genomics, Genomics of genetic eye diseases, Genetics of disorders of sex development, Transcription factors in developmental disease

Angiogenesis, Muscle, Metabolism, Exercise

My laboratory focuses its research on investigating how endothelial cells rewire their metabolism during angiogenesis and how endothelial cells metabolically communicate with other cell types in their microenvironment to maintain or establish organ homeostasis. Specific interest goes to deciphering mechanisms of blood vessel growth and endothelial metabolic crosstalk in the muscle following exercise and/or muscle injury.

Surgery with special focus on breast cancer surgery, Oncoplastic and reconstructive breast surgery

Applications and limitations of sentinel lymph node biopsy, De-escalation of axillary surgery, Oncoplastic and reconstructive breast cancer surgery with special focus on oncological safety, Patient-reported outcomes and quality of life, Tumour immunology

Health psychology; Preventive Medicine; Public Health, Health Care; Movement and rehabilitation Sciences; Epidemiology

health promotion, intervention studies, social and environmental determinants of behavior

Cognitive Neuroscience of Language

Language Learning, Huntington's disease, ERPs, fMRI, DTI

Social and Bahavioral Sciences

Cognitive neuroscience, audiovisual interaction in the brain, emotions, face recognition, facial expressions, neuropsychology, philosophy of mind, psychonomics

Medical Oncology, focus on interdisciplinary, translational research, aiming for personalized medicine.

Breast cancer research: clinical trials, long-term consequences of a breast cancer diagnosis. Diagnosis and therapy of neuroendocrine tumors. Translational oncology: Exploiting the apoptotic route for cell death induction with focus on the TRAIL route and early clinical trials with novel anticancer agents. Molecular imaging: Her molecular imaging research focuses on neuroendocrine tumors and the visualization of tumor specific targets including cancer drug targets, and in particular in breast cancer.

translational immunology

In 1997 I joined the Department of Tumor Immunology. By the end of that year I was able to provide the first DC-based vaccine for a melanoma patient, the first patient receiving DCs in the Netherlands. This was achieved by a close collaboration with the Departments of Medical Oncology and Hematology. Over the last 8 years, we succeeded in establishing a clinical vaccination program in which tumor-associated antigens loaded on DCs to treat both melanoma and colon cancer patients. To date, I have set out to translate DC vaccination into the pediatric oncological clinical setting. My primary scientific interest continues along the line of DC-immunotherapy and in particular the migration and imaging of DC. Throughout the past period I have intensively studied migration of DCs both in vitro and in vivo (preclinical mouse models, melanoma patients) and demonstrated that mature DCs are superior to immature DCs. I was the first investigator who showed the exact localisation of ex vivo labeled cells with MRI in humans. This early clinical work is very laborious requires intense communication with a large number of clinical departments. Another exiting project I started is targeting of antigens via FcγRII on PDCs. We recently showed for the first time that PDCs can present exogenous antigens to CD4+ T cells, indicating that they can significantly contribute to an immune response. We took advantage of our unique patient material: Antibodies directed against control-protein KLH formed during DC-immunotherapy facilitated the uptake of this protein by PDC. Subsequent presentation to T cells, again derived from vaccinated patients, was shown by proliferation. This is a clear demonstration how clinical studies can boost fundamental research, since this study could only be performed because of the valuable patient material available. Therefore, I strongly believe that basic research integrated with clinical application provides great opportunities for both sites!

Gastroenterology and hepatologyhead of the Laboratory of Experimental Medicine and Pediatrics (Gastro & hepato, Nephrology, Intensive care, Pneumology, Diabetology & Obesity & Metaboloic disease, Pediatrics, Neonatology)

IBS, IBD, Sepsis, Ileus, Visceral pain, Inflammation, Intestinal permeability

Neurosciences, Brain research, Cognitive development in infants and children

Pediatrician, I am a CNRS full-time researcher and I lead the developmental neuroimaging lab which comprises 10 people at INSERM, Neurospin, Paris-Saclay University, France. Our approach is to use non-invasive brain imaging techniques to investigate the development of cognitive functions in children. My goal is to understand how complex cognitive functions emerge in the human brain by determining the primitive functions accessible to an infant brain in order to process the external word at the beginning of life, and how these initial biases in brain organization are shaped by a human environment and culture.

Diabetes, cardiovascular disease, obesity, metabolism

diabetes, biochemistry

Glycobiology, Biopolymer mass spectrometry, Carbohydrate chemistry, Glycomics.

Applications of high sensitivity mass spectrometry to the structure analysis of glycopolymers. Understanding glycan function. Glycosylation and disease. Glycoengineering. Host-pathogen glycan-mediated processes.

Field: genetics. Area of specialization: ophthalmology

Molecular causes of eye diseases; retinal dystrophies (retinitis pigmentosa, cone-rod dystrophy, cone dystrophy, Leber congenital amaurosis), age-related macular degeneration (AMD), glaucoma, retinal detachment, diabetic retinopathy

brain and synaptic plasticity; neurodegenerative diseases as Alzheimer and Parkinson Disease

Her primary research interest is related to brain and synaptic plasticity both in physiological and pathological conditions, with the primary aim to apply her basic findings to the cure of neurodegenerative diseases as Alzheimer and Parkinson Disease. In the last 15 years she focused on the understanding of the molecular mechanisms regulating the composition, the structural organization and the dynamic of the glutamatergic synapse.

Molecular, Cellular and Biochemical Sciences

DNA damage and repair and the link to human pathologies

Neurology

Neurosciences, multiple sclerosis, optic neuritis, neurodegeneration, neuroprotection

Neurobiology, biochemistry

The present research programme focuses on molecular, cellular and systemic aspects of neuronal and glial function and synaptic plasticity.

Psychoneuroendocrinology, Clinical Psychology, Psychotherapy

Stress and Stress Hormones, Social Interaction, Couple Interaction, Psychosocial Aspects of Gynecological Disorders, Neuropsychopharmacology

Molecular Biology

Molecular regulation of lipid mediated intracellular signals with special emphasis on pathogenesis of type 2 diabetes. By using viral gene therapy, functional genomics and biochemical approaches, my team aims to uncover cellular mechanisms of insulin resistance and pancreatic beta cell dysfunction.

Protein chemistry, proteomics, mass spectrometry

Mass Spectrometry, Lipidomics, Proteomics

Neuroscience, Neuropharmacology, Ion channels, Pain

Voltage-gated calcium channel function, determined by electrophysiology and by optical methods Calcium channel trafficking, relationship of calcium channel function to the development and maintenance of neuropathic pain

Neuroscience, Neurophysiology, Human Locomotion research

Neuromotor Control, Development of locomotion in children, Brain research, Biomechanics, Muscular activity (emg), Neuroimaging (eeg)

Hypertension, Endocrinology, Genomics, Stratified Medicine

Hypertension Endocrinology Genomics Stratified Medicine

Psychiatry, psychology, anxiety, anxiety disorders, depression

Predicting and preventing mental illnesses; biomarkers; genetics, epigenetics, imaging genetics, therapeutic genetics.

Human Immunology

Antigen specific T cells in virus infection and Cancer

Cellular Neurosciences

Neurodegenerative diseases RNA-binding proteins Nuclear transport Cellular stress Phase transitions

Epidemiology

Musculoskeletal pain conditions, back pain

Psychiatry, Developmental disorders of the brain, Neuroimaging

Autism Attenttion Deficit and Hyperactivity Disorder