Plant Ecology, Conservation Biology, Landscape Genomics

The focus of my research is on examining the impact of habitat fragmentation on gene- to species-level aspects of biodiversity and related ecosystem services.

Evolutionary biology, Evolutionary genetics

Sex differences, Sex chromosome evolution, Sexual selection

Environmental virology, Molecular and structural biology, biochemistry

Giant viruses diversity, Giant viruses physiology, Host/pathogen cross-talk, Role of DNA viruses in evolution, viruses and the origin of life

Cell Biology, Cellular and Molecular Neuroscience, Vascular Biology, Tumour Biology

Neurovascular link, Neurodevelopment, Developmental and pathological angiogenesis, Glioma invasion

Microbial bioelectrochemistry, Microbial electrophysiology

Microbial electrophysiology, Droplet microfluidics for microbiology, Defined microbial co-cultures

Cell Biology, Cellular signaling, Cancer biology, Cancer therapy

Molecular mechanisms of cancer cell resistance to therapy, Autophagy, Cell death pathways, Endoplasmic reticulum stress, Membrane contact sites, Immunogenic cell death, Oxidative stress, Immunotherapy, Vascular biology and (lymph)angiogenesis

Evolutionary biology, Animal behaviour, Gender studies, Science studies

Feminist science studies, History of evolutionary biology, Gender/queer perspectives on biology, Anti-oppressive biology teaching

cell biology, molecular biology, biomedicine

cell death, lysosomes, apoptosis, autophagy, cancer biology, neurobiology, high-content screening

Cell Biology, Molecular Biology, Biochemistry, Microscopy

Cell organization and dynamics cytoskeleton cellular transport cell differentiation migration and division tissue morphogenesis

Evolution, genomics, bioinformatics

I am interested in understanding the evolutionary mechanisms that are behind the emergence of novel genes in genomes. I am also studying the role of repetitive sequences in the expansion of coding sequences and the formation of novel protein domains.

Molecular biology, molecular microbiology, biochemistry, membrane protein biochemistry

Bioelectrochemistry, Synthetic Biology, Chemical Biology

Engineering of Electron Transfer Pathways Genetic Code Expansion

Translational research, invasion, metastasis, disseminated tumor cells, transcription, tumor-associated proteolysis, targeted therapy, micro-RNAs, molecular staging of cancer

Biology and Biomedicine

Developmental biology, Regeneration, Quantitative imaging, Zebrabish, Morphogenesis, Tissue mechanics

Molecular biology, Virology

My field of research involves the development of oncolytic viruses as cancer immunotherapeutics.

Natural Resources

Ecology, Behavioural Ecology, Chemical Ecology, Evolutionary Ecology

Neurophysiology (synaptic physiology)

Epilepsy (development)

Molecular Evolution, Cell and Molecular Biology

host-adapted bacterial genomes, interplay between bacteria and higher organisms

Developmental biology, Hepatology, Neuroscience, Vascular biology, Tissue patterning, Morhogenesis, Stem cell biology, Transdifferentiation

Biochemistry and biophysics

Structural biology (protein X-ray crystallography), Membrane proteins, Transporters and Channels, Metalloproteins, Proteoliposomes, Planar lipid membranes, Electrophysiology, Spectroscopy

Hematology, Internal Medicine; Special focus: hemostasis and thrombosis, laboratory diagnosis particularly in the field of hemostasis and thrombosis, myeloproliferative neoplasms and their bleeding/thrombotic complications

Experimental and translational research in the field of hemostasis and thrombosis Clinical research in the field of hemostasis and thrombosis Experimental, translational and clinical research in the field of myeloproliferative neoplasms

Bioinformatics, Computational genomics and modeling Molecular evolution

Together with my students I work on theoretical aspects of modeling molecular evolution as well as data-driven applications of our new methodologies. We are broadly interested in applying computational methods to study the process of gene and genome evolution and in particular the process of adaptive genetic change. Growing genome-scale sequences and information from complimentary disciplines of transcriptomics, proteomics and metabolomics have begun to seriously impact genomics. But the challenge of understanding the dynamics of such large-system data can only be met through an integration of organism, molecular, and mathematical disciplines. New techniques need to be developed for discovering complex patterns from multi-faced systems biology data.

Molecular Microbiology, Microbial Proteomics and Redox biology

1) Bacterial redox-sensing regulators and the role of bacterial redox buffer 2) Proteomics and Thiol-Redox proteomics in Gram-positive bacteria 3) Bacterial secretome analyses

Behavioural Ecology; Animal Cognition

Social Networks Animal Culture Cognitive Ecology

Neuroscience

Neuronal circuits, motor behavior, genetics

Evolutionary ecology

Insect immunity Host-pathogen interactions Ecological immunology

Molecular biotechnology, Biochemistry, Synthetic biology

Biochemistry, Molecular biology, Protein engineering, Protein design, Synthetic biology, Systems biology, Tumour biology

Biogeochemical cycles, vegetation modelling, climate change

Interactions between climate change - changes in land use - terrestrial ecosystems Interactions between fire–climate–vegetation

Biochemistry, Molecular and Cell Biology

Mitochondrial Pathophysiology Intracellular Signaling Intercellular Communication Neuroenergetics Neurodegeneration Hypoxia/Ischemia Neuroprotection

Membranes and Transport

Cellular Metabolism, Membranes and Transport, Molecular Medicine

Developmental Biology

Cell fate specification Cell signalling Gene expression

Plant Sciences

Plant nutrition/ Adaptation to abiotic stress - excess and deficiency of micronutrients-metals/ Regulation/ Transport

Molecular and cellular neurobiology

Cortical development Cortical injury

Molecular Evolution, Evolution of antibiotic resistance

I'm interested in the ancient evolutionary origins of core cellular processes. My work is also concerned with how bacteria have adapted components of these core processes in their evolution of antibiotic resistance.

Molecular Biology, Cell Biology, Biochemistry, Biology

DNA topoisomerase II

Molecular Medicine, Genetics, Epigenetics, Hearing and deafness

Hereditary hearing loss, Epigenomics of the auditory system

Meiosis, chromatin structure regulation, spermatogenesis, fertility

Chromosome pairing, chromatin reorganisation during gametogenesis, the impact of the paternal epigenome on early embryo development

Molecular Biology

Cell Signaling

Medical genetics, Pediatric genetic diseases, Developmental biology

Ciliopathies, Primary cilium biology, Genetic and phenotypic variability in Mendelian disorders

Molecular Medicine

Molecular Medicine, RNA, Neuroscience

Genomic, Computational Biology

Structural Biology and Biophysics, Genomic and Computational Biology, Systems Biology

Functional dissection of signal transduction pathways in lymphocyte activation and apoptosis and dysregulation of these processes un lymphoproliferative, immunodeficiency and pathogen-related diseases

Immunology, Molecular Medicine, Signal Transduction

Food Science and Technology, Postharvest Pathology

Food agrochemistry and technology, Postharvest Biotechnology, Molecular biotechnology

Biological Inorganic Chemistry, Magnetic Resonance spectroscopies, NMR, Structural Biology

Proteins and Biochemistry, Structural Biology and Biophysis, Systems Biology, Metals in Life Sciences, Cellular Structural Biology, Structural Vaccinology

Science and Technology of Materials, Bioorganic chemistry

Bio-nano-medicine, Drug delivery systems

Stem cell biology, genome instability, development, aging

Stem cell regulation, genome maintenance, stem cell aging, stem cell epigenetics, somatic mutation

Structural Biology, Telomere Structure, Chromatin Structure

Telomere structure, dynamics and telomerase recruitment Chromatin structure and regulation

Microbiology, Virology, Pathogens

Retrovirology, Immuno-virology, Pathogenesis, HIV/AIDS Basic research at the interface of clinical research (translational research) Mechanisms of protection against HIV/SIV infections and/or AIDS

Plant molecular biology

Gene regulation under abiotic stress Chromatin and transcription Signal transmission Proteomics Plant hormones (ABA)

Developmental biology, molecular biology

regeneration and development of tissue and organs biology of stem cells

Biochemistry (Protein biochemistry)

Protein crystallography Blue-light photoreceptor proteins Regulatory mechanisms of visual signal transduction (arrestin-GPCR interaction) Viral proteases Protein–ligand interactions with SH3 proteins Motor proteins (actin-myosin) Protein aggregation Protein stability in aqueous and non-aqueous/organic solvents

Evolutionary biodemography

Development of new concepts, models, and theories for understanding the evolution of aging in light of biodiversity

Pflanzengenetik, Pflanzenentwicklungsbiologie, Stressbiologie, Epigenetik

Interaktion Pflanzenentwicklung-Umwelt, Stressgedächtnis

Plant Biology

Intercellular communication / Plasmodesmata / Membrane contact site / Membrane lipid

G protein-coupled receptors, proteins, peptide pharmaceutical drugs, biocompatible material

Peptide hormones/GPCR Chemical modification of proteins Tumour research/oncology Metabolism research Biomaterials/surface modification

Protein biochemistry, Malaria, Structural biology, Drug development

Biochemistry of redox metabolism, Rational development of drugs to fight malaria and tumour-based diseases, Parasite-host interactions, Redox proteins, Selenoproteins

Microbiology, synthetic biology, molecular genetics, microbial genomics

Microbe-plant interactions; bacterial regulatory networks, cell biology and genome organization; bacterial platform organisms for biotechnology and synthetic biology; DNA digital information storage

Organic Chemistry, Natural Product Chemistry, Applied Microbiology, Microbial Biotechnology, Chemical Ecology

My research combines different aspects of chemical ecology and organic and natural product chemistry and aims to chemically and functionally characterize microbial signaling and defense molecules in different symbiotic model systems.

Cell biology, biochemistry

Genome stability, chromatin biology, ubiquitin, protein homeostasis, posttranslational modifications, mass spectrometry-based proteomics

Cancer BiologyCellular and Molecular BiologyMetabolism

Energy Metabolism Glycation and Oxidation Stress Metastasis Development Resistance to Cancer Therapy

Microbiology

Microbiology Cell biology Microbial development Microbial cell-cell communication

Biotechnology, microbiology, biological plant protection

Microbial diversity Environmental biotechnology

Psychiatric genetic epidemiology

Schizophrenia, bipolar disorder, eating disorders, depression

Biochemistry, molecular biology, structural biology, biophysics

Gene expression Protein synthesis Ribosomes Translational control Cryo-electron microscopy Ribosome Display

Immunology, Developmental Biology, Molecular Biology

Epigenetics Stem cells and cell fate decisions Monoallelic expression Cancer Regulation of immune cell development

Yeast Genetics, Genomics and Cell Biology; Candida albicans Genome dynamics; Drug Resistance in pathogenic fungi; Rapid evolutionary processes; Centromeres, Replication, Telomeres, Repetitive DNA, Aneuploidy

Pharmacology, bio-engineering, imaging, biotechnology, Biology, Neurosciences, Cell Biology, Cellular and Molecular Neuroscience, Vascular Biology, Neurobiology

Brain ischemia, stroke, brain tumour, hypoxia, hypoxia-inducible factors, regeneration, neuroprotection, cell therapy, mesenchymal stem cell, imaging, therapeutic

Signal Transduction

Chromatin and Transcription Signal Transduction Molecular Medicine

Evolutionary Biology

Evolution of mating systems Evolutionary Ecology of Cooperation Population genetics and genomics Behavioural Ecology Sex-ratio and life history evolution

Cell and reproductive biology, Andrology, Endocrinology

Hormonal regulation of the male reproductive system (animal models), The role of steroid hormone receptors, Cell-cell junctions in the testis, Gap junctional communication in the testis

Biophysics, Physical chemistry

Single molecule fluorescence spectroscopy and microscopy, DNA nanotechnology and bionanotechnology, structural biology

Virology, Molecular biology, Cell biology, Biochemistry

Infection and Replication of Retroviruses

Food hygiene

Microbial food spoilage and hygiene, microbial interactions, (meta)genomics and (meta)transcriptomics of food spoilage communities, lactic acid bacteria and enterobacteria

Specialisation in forensic anthropology, the legal determination of identity, human anatomy and research into child sexual exploitation

Research is in novel biometrics, forensic anthropology, identity and human anatomy

Development of neuronal diversity

Immunology, Parasitology, Genetics, Molecular and Cellular Biology

Malaria, Mosquito, Anopheles gambiae, Host-pathogen interactions, Insect immunity, Genetics, Bioinformatics

Biophysical Chemistry & Nanobiotechnology

single molecule fluorescence spectroscopy single molecule force spectroscopy protein dynamics enzyme kinetics enzyme optimization & biocatalysis biohybrid chemistry

telomeres, telomerase, DNA repair epigenetics, stem cells, induced pluripotent stem (iPS) cells nuclear reprogramming cancer ageing, longevity, health span

Molecular microbiology, bacterial genetics, biochemistry

Evolution of bacterial pathogens Horizontal gene transfer Environmental reservoirs of facultative pathogens

Medical protein chemistry, Immunology

Immunology, the complement system, infections, cancer, autoimmune diseases, protein chemistry

Microbiology, biogeochemistry

Geomicrobiology Methane biogeochemistry Ecology of chemosynthetic habitats Microbial biodiversity Microbial processes of early diagenesis in deep-sea sediments Effects of pressure and temperature on microbial processes Pelago-benthic coupling in Polar Seas General Microbial Ecology Microbial symbiosis Deep-sea ecology Marine carbon cycle

Rare diseases, Neurological and neurodegenerative diseases, Fundamental neurosciences and therapy

I study rare diseases, to increase our understanding of fundamental neurosciences and to exploit this knowledge to diagnose and treat neurological diseases. I have been focusing on rare neurodegenerative diseases since my PhD in Human genetics, and the laboratory apprehends this with a multidisciplinary approach (genetics, cell biology, physiology) and multiple model systems (cells, mouse & zebrafish). This allowed us to uncover novel regulatory mechanisms of key pathways: cytoskeleton, autophagy and neuronal identity, and to develop therapeutic strategies for a devastating disease called GAN. My early interest in rare diseases comes from my conviction that we can solve important biological questions with this angle, that this can be of benefit to many neurodegenerative diseases, and from my dedication to find therapeutic solutions to patients, suffering from dramatic, yet often neglected pathologies.

Genetics, microbiology, molecular phytopathology

Protein transport systems, bacterial pathogens, Type-III effector proteins, signal transduction, sRNAs in Xanthomonas

Biochemistry, Biophysics

Membrane protein folding and assembly Membrane lipids Membrane protein function and regulation Protein Dynamics Synthetic Biology

Basic and applied biomedical research in general, Veterinary medicine, Physics

In vivo imaging, Magnetic resonance imaging and spectroscopy, Translational neuroscience

Membranes and Transport

Organelle biogenesis and membane traffic; membrane proteins; protein targeting; Endoplasmic Reticulum

Wheat genetics; senescence and nutrient remobilisation; cereal grain nutritional value; genomics

Wheat grain nutritional value; genomics

Physiology of adipose tissue and obesity

Insulin resistance Inflammation Progenitor cells Angiogenesis

Regenerative Medicine, Tissue Engineering, Mechanobiology

Cardiovascular regeneration, cardiac tissue, heart valves, vessels, extracellular matrix My research concentrates on cell-matrix interactions in cardiovascular tissues, with special emphasis on regulating growth, differentiation, adaptation and remodeling for tissue regenerative purposes. I use "living" model systems at different length scales (cell, cell-matrix, engineered tissue, native tissue) to quantify and manipulate these aspects, preferably in a real-time and high-throughput fashion. Current research topics concern the biophysical (stem)cell niche, tissue engineered disease models, and restoring matrix architecture and mechanotransduction in compromised cardiovascular tissues.

Developmental Neurobiology

Neuroscience Development Differentiation and Death

Embryology, developmental biology

Signal-directed cell migration Myogenesis Gene regulation Transcription factors

Biology, molecular biology, bacterial genetics

Small regulatory RNAs in gram-positive bacteria Transcription regulators in bacteria

DNA Repair, Replication, Recombination, cell cycle, DNA topology, chromatin structure

Chromatin, DNA replication, chromosome structure, DNA repair

Immunology, Parasitology, Helminth Infection Immunology

Murine models of nematode infections: immune response and immune modulation

Molecular Cell Biology, Biochemistry

Cell Signaling, Ubiquitin-Proteasome System, Autophagy

Human Nutrition, Metabolomics

Use of a metabolomic approach to identify novel biomarkers of dietary intake , Use of metabolomic signatures (“metabotypes”) to identify responder’s to dietary interventions in a move towards personalised nutrition, Development of functional foods to improve glycemic management

Mycobacteria, macrophages, phagosome, neurons, GPCR, potassium channels, cellular signalling

Mycobacterium tuberculosis and Mycobacterium ulcerans, the molecular and cellular signalling pathways targeted by the major mycobacterial virulence factors, namely the ESX1 secretion system and the polyketide mycolactone

Trained as an experimental physicist, Lene Oddershede works at the crossroad between physics, medicine and biology. She is an expert on optical manipulation, biophysics, interaction between light and nanoparticles, and on biophysics of cells, with a special interest in stem cells.

Biophysics, nano-bio-photonics, medical physics, stem cells, nanoparticles, nanotechnology, physics, optics

Experimental Sciences; Aquatic Ecology; Water; Climate change; Limnology, Conservation and Restoration of aquatic ecosystems

Evaluation of anthropogenic impacts (e.g. climate change, eutrophication, salinization, habitat destruction) on the biodiversity and functioning in aquatic ecosystems. In particular, the study of organisms size structure and how it is affected by environmental changes. Other main interests include ecological assessment, management, conservation and restoration of aquatic ecosystems and zooplankton ecology.

Immunology

Immune regulation mucosal immunity autoimmunity alveolar epithelium host-pathogen interaction infection and autoimmunity regulatory T cells immune modulation in the context of infections

Plant biochemistry, photosynthesis

Proteins in the thylakoid membrane: structure, interaction, regulation, pigments Diatoms, cyanobacteria, spermatophytes

Ecology, biogeochemistry, plant ecology, biodiversity, greenhouse gas exchange between the biosphere and the atmosphere, ecophysiology, stable isotopes

Ecology, plant and ecosystem ecophysiology Biogeochemistry Trace gas fluxes Stable isotope ecology Functional biodiversity

Microbiology, Infection biology, Cell biology, Genomics

Infectious Diseases, Evolution of bacterial pathogens, Horizontal gene transfer, Host-pathogen interactions

Computational biology, Bioinformatics, Mathematical modelling, Genomics, Epigenetics, Trascriptomics

Computational: machine learning, agent-based modelling, omics biomarkers; Biology: cancer biology, tumour microenviroment, hypoxia; Omics: transcsriptomics, genomics, epigenetics, single-cell sequencing, spatial transcriptomics

Biology and Biomedicine

Lignocellulose biodegradation by saprotrophic fungi, Oxidoreductase enzymes: ligninolytic peroxidases and laccases, Enzyme structure-function studies, Laccase-mediator systems, Enzyme directed evolution to develop tailor-made biocatalyst, Enzyme Heterologous expression in yeast, Phylogenetic studies, Lignin valorization, Use enzymes as biotechnology tools for biomass conversion to obtain new bio-based products to replace fossil-based products, White Biotech for developing more efficient, cleaner and sustainable industrial processes to contribute to the Bioeconomy concept

Agricultural Sciences, Soil Sciences

Viticulture, Organic agriculture, Soil food webs, Biological Control, Nematology

Analytical chemistry, electrochemistry, surface chemistry, nanomaterial science, biophysics and neurochemistry

The biophysics and chemistry processes that control cell functions, in particular the exocytosis process in neuronal communication.

Neuro-endocrine-immunology, Experimental rheumatology

Role of neuronal-like mechanisms used by non-neuronal cells to modulate inflammation, Dopaminergic pathways in rheumatic diseases, Stress-related effects on immune response, Neurotransmitter-immune cells interaction during aging, Sex-specific differences in the neurotransmitter-immune cells interaction

Immunology

Immunoregulation, autoimmune disease, tumor immunity

(1) Science: Systems Neuroscience, computational neuroscience, neurotechnology, brain machine interface, science and research management; (2) Innovation & Entrepreneurship: Funding for Startups / Spinoffs. Funding for research & development in academia & industry, grant counseling; (3) Career paths and decisions, career counseling, workshops and lectures; (4) Science management

Computational neuroscience Motor control Brain-machine interfaces Neurotechnology Novel therapies

Genetics, cell biology, tumor biology, pathology, neuro-oncology

Epigenetics, cancer stem cells, neural stem cells, brain tumors, childhood tumors

Animal Behaviour, Olfactory communication, Behaviouural Ecology

Olfactory communication in vertebrates, causes and consequences of individuality, impact of microbes on individuality and olfactory communication

Neurobiology, development of the nervous system, formation of neuronal connectivity

Characterization of gene pathways controlling early steps of the formation of the nervous system Characterization of developmental programs reactivated during tumorigenesis

genetics, molecular biology

infectious diseases, malaria, vector control, mosquito reproductive biology

NeurologyNeuroscienceTranslational Medicine

The main goal of my research is to unravel pathophysiological mechanisms and therapeutic targets for basal ganglia disorders and other related brain diseases. To pursue this goal, my research group utilise several methodologies (physiology, biochemistry, histopathology, molecular biology, brain imaging, and behavioural neuroscience). We apply these methodologies to animal models of disease that we continuously develop and optimize. We pay great attention to verify the relevance of our experimental findings to the human diseases by using different types of biomarkers. I am particularly recognised for my work in the area of Parkinson’s disease (PD) and L-DOPA-induced dyskinesia (LID), for which we have developed experimental models and key pathophysiological notions that are widely accepted today. On a more general level, I am intrigued by the brain’s capacity for plasticity and repair and interested in harnessing and boosting it for therapeutic purposes. To achieve this goal, I would like to develop innovative treatments combining pharmacological and rehabilitative principles.

molecular and cell biology

mitochondria, cellular protein homeostasis

Cancer epidemiology and genetic epidemiology

Non-genetic and genetic determinants of cancer risk and prognosis, with a focus on breast cancer and colorectal cancer Prediction of risk and prognosis Non-genetic and genetic determinants of radiatherapy toxicity, with a focus on breast cancer

Evolutionary Biology, Behavioural Ecology, Ecological Genomics

Local adaptation at small spatial scales Adaptive and non-adaptive responses to climate change Evolutionary importance of extreme climatic events Adaptation to urban habitats Sexual selection and evolution of sexual ornaments Natural selection and microevolution in natural populations Spatio-temporal fluctuations in natural selection Evolutionary ecology of bird personality Evolutionary constraints and multivariate quantitative genetics Evolution of senescence

Neuroscience / Development

synapse / synaptogenesis / synaptic plasticity / human evolution / postsynaptic scaffold

Molecular Medicine

RNA editing / ADARs / transcriptome / cancer

Restoration of bodies of water, phytoplankton ecology, particularly that of potentially toxic cyanobacteria

Factors influencing the occurrence of varieties of phytoplankton, particularly the cyanobacteria

Cell biology, Stem cell Biology, Developmental biology of mammals

Embryonic stem cells differentiation, myogenenesis, cell cycle regulation, regenerative medicine

Molecular Biology, Molecular Genetics, Biochemistry

DNA damage response, Ubiquitination, Chromatin - Epigenetics, Hematopoietic stem cells, Cancer, Stem Cells

Proteins and Biochemistry, Structural Biology and Biophysics

Protein folding, misfolding and assembly

Cell and developmental biology

Epithelial homeostasis, Tissue regeneration, Signaling, Chromatin, Adhesion, Cytoskeleton

Peptide chemistry, Protein chemistry, Biochemistry, Molecular biology, Expanded genetic code, G protein coupled receptors, Arrestin

My group investigates topologies of protein-protein interactions in the live cell by combining chemical tools and modern molecular biology techniques. We use the expanded genetic code technology to incorporate crosslinking amino acids into proteins at specific sites, and we map systematically interactions surfaces to discover regions of proximity of associated partners. We are currently focused on unveiling the binding mode of natural peptide hormones to class B GPCRs and investigating the topology of interactions involved in GPCR-associated protein complexes.