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Kerstin Bartscherer Receives ERC Starting Grant

12. 10. 2016 | With the grant's 1,5 million Euros, group leader Dr. Kerstin Bartscherer will set out to investigate how the regeneration of injured or lost body parts can be activated. The project is expected to provide fresh impulses to regenerative medicine.
State-of-the art technology and a unique combination of animal models will enhance our understanding of how regeneration processes are induced in animals whose capacity for regeneration is greatly superior to that of humans. The protagonists in this promising area of research are planarians – they are accomplished masters of regeneration who, within a matter of days, can grow an entire head. This elevated plasticity can be attributed to the ability to recognize loss of tissue and immediately induce regeneration. Planarians belong to a species of flatworms, some are even even capable of growing an entire head, including the brain. The mechanisms how planarians and other animals with high plasticity react to different types of injuries have not yet been resolved. The research project is scheduled for two years and is expected to provide fresh impulses to regenerative medicine.

Dr. Kerstin Bartscherer
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Dr. Kerstin Bartscherer
"If we understand how some animals activate and stabilize the regeneration process, we can draw important conclusions, which hopefully, some day will also help us to trigger regeneration also in humans", says Kerstin Bartscherer, Max Planck group leader at the Max Planck Institute for Molecular Biomedicine. "For this purpose, animal models and comparative studies are indispensable. With the project subsidized by the European Research Council we intend to explore the cellular and molecular mechanisms capable of inducing regeneration of injured or missing body parts, thereby tracking blockades which prevent successful regeneration."

For this purpose, Kerstin Bartscherer will use planarians and zebrafish, which – contrary to humans – can quickly replace amputated body parts, without even leaving scars. "The strength of our project's approach is the unique combination of regenerative model organisms and state-of-the-art technology", Bartscherer explains.

The European Research Council ERC supports highly innovative research projects. "Excellent research always depends on an inspiring and supportive environment – a condition more than met in the present case. The MPI for Molecular Biomedicine maintains close collaborations with the institutes of the Westphalian Wilhelm's University in Münster and the Cluster of Excellence research groups 'Cells in Motion'," Kerstin Bartscherer praises Münster's potential for research.

The fact that Bartscherer was awarded the grant is a renewed recognition of Münster as location for European cutting-edge research on regeneration and stem cell biology. In 2015, the ERC awarded an ERC Advanced Grant for a research project on stem cell-based regeneration to the Max Planck Director Hans Schöler. In 2013, another Advanced Grant dedicated to research on blood vessels and their importance in the formation of new bone tissue went to Max Planck Director Ralf Adams. In addition, the MPI Research Group Leaders Sebastian Leidel (2012), Arndt Siekmann (2010) and Takashi Hiiragi (2007) all won one of the prestigious ERC Starting Grants.
  (© Max Planck Institute for Molecular Biomedicine, AcademiaNet)

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