Recently, the group has performed the conditional and conventional knockout of the Raf kinases and of their effectors Mek. The knockout studies have defined essential in vivo roles of these proteins, several of which are unexpectedly independent of their enzymatic activity, and have changed the way we look at the pathway. The laboratory continues to focus on deciphering signaling pathways in vivo by conditional gene ablation in mice.
Manuela Baccarini is coordinator of the International PhD Program "Molecular Mechanisms of Cell Signaling" that she founded in 2009, and she is also Deputy Director at the Center for Molecular Biology at the Max F. Perutz Laboratories, where her research group is situated. Before coming to Vienna, she had been a group leader at the Fraunhofer Institute in Hannover, Germany.
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