Prof. Dr. Miriam Agler-Rosenbaum
Biological and related sciences, Microbial bioelectrochemistry, Microbial electrophysiology
Biological and related sciences, Education, Health
Cancer BiologyCellular and Molecular BiologyMetabolism
Energy Metabolism
Glycation and Oxidation Stress
Metastasis Development
Resistance to Cancer Therapy
2018 to date
President of the The Belgian Association for Cancer Research
2000
Young Investigator’s Talk Award of The Belgian Association for Cancer Research
1999
Young Investigator Award of The European Calcified Tissue Society (1999)
1995
Cancer Research Award from the Association Sportive contre le Cancer
1992
Young researcher award: Prize Van Beirs, University of Liège (Belgium)
Arabic, English, French
2008-2021 Associate Professor, University of Liège (Belgium)
Methylglyoxal scavengers resensitize mutated KRAS colorectal tumors to cetuximab.
J. Bellier, M-J. Nokin, M. Caprasse, A. Tiamiou, A. Blomme, J. L. Scheijen, B. Koopmansch, G. M. MacKay, B. Chiavarina, B. Costanza, G. Rademaker, F. Durieux, F. Agirman, N. Maloujahmoum, P. G. Cusumano, P. Lovinfosse, H. Y. Leung, F. Lambert, V. Bours, C. G. Schalkwijk, R. Hustinx, O. Peulen, V. Castronovo, and A. Bellahcène. Cell Reports (2020), 30(5):1400-1416.
Methylglyoxal-derived stress: An emerging biological factor involved in the onset and progression of cancer. Bellahcène A, Nokin MJ, Castronovo V, Schalkwijk C. Semin Cancer Biol. (2017), pii: S1044-579X (17) 30087-1.
Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis. Nokin M-J., Durieux F., Peixoto P., Chiavarina B., Peulen O., Blomme A., Turtoi A., Costanza B., Smargiasso N., Baiwir D., Scheijen J.L., Schalkwijk C.G., Leenders J., De Tullio P., Bianchi E., Thiry M., Uchida K., Spiegel D.A., Cochrane J.R., Hutton C.A., De Pauw E., Delvenne P., Belpomme D., Castronovo V. and Bellahcène A. eLife, (2016) 5:e19375.
Dentin Matrix Protein 1 induces membrane expression of VE-cadherin on endothelial cells and inhibits VEGF-induced angiogenesis by blocking VEGFR-2 phosphorylation. S. Pirotte, V. Lamour, V. Lambert, M-L. Alvarez Gonzalez, S. Ormenese, A. Noël, D. Mottet, V. Castronovo and A. Bellahcène. Blood (2011), 117:2515-26.
Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer. Bellahcène A, Castronovo V, Ogbureke KU, Fisher LW, Fedarko NS. Nature Reviews Cancer (2008), 8 (3) : 212-26.
5. Runx2- and histone deacetylase 3-mediated repression is relieved in differentiating human osteoblast cells to allow high bone sialoprotein expression. Lamour V, Detry C, Sanchez C, Henrotin Y, Castronovo V and Bellahcène A. Journal of Biological Chemistry, 282 (50) : 36240-9.
Dentin matrix protein 1 is expressed in human lung cancer. M. Chaplet, L. de Leval, D.
Waltregny, C. Detry, G. Fornaciari, G. Bevilacqua, L.W. Fisher, V. Castronovo and Bellahcène A. Journal of Bone and Mineral Research (2003), 18,1506-1512.
Bone sialoprotein mediates human endothelial cell attachment and migration and promotes angiogenesis. Bellahcène A., Bonjean K., Fohr B., Fedarko N.S., Robey F.A., Young M.F., Fisher L.W. and Castronovo V. Circulation Research (2000), 86 (8) : 885-891.
Prognostic value of bone sialoprotein expression in clinically localized human prostate
cancer. Waltregny D., Bellahcène A., Van Riet I., Fisher L.W., Young M., Fernandez P., Dewé W., de Leval J. and Castronovo V. Journal of the National Cancer Institute (1998), 90 (13) :1000-1008.
Expression of bone sialoprotein, a bone matrix protein, in human breast cancer. Bellahcène A., Merville M-P. et Castronovo V. Cancer Research (1994), 54 : 2823-2826.
2018-2022
Novel Connection between Glycation stress and Epigenetic regulation, FNRS-PDR
2011-2015
European Union Framework Programme 7, Marie-Curie (ITN) « BONE-NET »: European Training Network on Cancer induced Bone Disease (N° PITN-GA-2010-264817)
2019
Member of FNRS-FRIA jury
Member of the Board of Biobank of the University of Liège and Liège University Hospital (Belgium)
2011-2018
Member of the Board of The Belgian Association for Cancer Research
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Biological and related sciences, Microbial bioelectrochemistry, Microbial electrophysiology
Biological and related sciences, Environment, Plant Ecology, Conservation Biology, Landscape Genomics
Biological and related sciences, Health, Cell Biology, Cellular signaling, Cancer biology, Cancer therapy
Biological and related sciences, Evolutionary biology, Animal behaviour, Gender studies, Science studies