Akeila Bellahcène

• Since 2018
  co-Head of the Metastasis Research Laboratory, GIGA-Cancer, GIGA Institute, University of Liège (Belgium)
  
  

• Since 2016
  Research Director, National Fund for Scientific Research (FNRS, Belgium)
  
  

• 2008-2021 Associate Professor, University of Liège (Belgium)

   
  « Biology : cells, organisms and populations »: a course for 1st year Pharmacy and Biomedical Sciences students, University of Liège (Belgium)
  
  

• 2008 – 2016
  Senior Research Associate, National Fund for Scientific Research (FNRS, Belgium)
  
  

• 2007
  Aggregation Thesis, University of Liège (Belgium)
  
  

• 1999
  Post-doctoral Fellow at the National Institutes of Health, Bethesda (USA)
  
  

• 1998
  PhD Thesis in Experimental and Biomedical Sciences, University of Liège (Belgium)
  
  

• 1992
  Tropical Biology Diploma, Institute of Tropical Medicine “Prince Léopold”, Antwerpen (Belgium)
  
  

• 1992
  Pharmacist Specialized in Clinical Biology, University of Liège (Belgium)
  
  

• 1988 and 1996
  Pharmacist, University of Algiers (Algeria) and University of Liège (Belgium)
  
  

• Methylglyoxal scavengers resensitize mutated KRAS colorectal tumors to cetuximab.

  J. Bellier, M-J. Nokin, M. Caprasse, A. Tiamiou, A. Blomme, J. L. Scheijen, B. Koopmansch, G. M. MacKay, B. Chiavarina, B. Costanza, G. Rademaker, F. Durieux, F. Agirman, N. Maloujahmoum, P. G. Cusumano, P. Lovinfosse, H. Y. Leung, F. Lambert, V. Bours, C. G. Schalkwijk, R. Hustinx, O. Peulen, V. Castronovo, and A. Bellahcène. Cell Reports (2020), 30(5):1400-1416.

• Methylglyoxal-derived stress: An emerging biological factor involved in the onset and progression of cancer. Bellahcène A, Nokin MJ, Castronovo V, Schalkwijk C. Semin Cancer Biol. (2017), pii: S1044-579X (17) 30087-1.

• Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis. Nokin M-J., Durieux F., Peixoto P., Chiavarina B., Peulen O., Blomme A., Turtoi A., Costanza B., Smargiasso N., Baiwir D., Scheijen J.L., Schalkwijk C.G., Leenders J., De Tullio P., Bianchi E., Thiry M., Uchida K., Spiegel D.A., Cochrane J.R., Hutton C.A., De Pauw E., Delvenne P., Belpomme D., Castronovo V. and Bellahcène A. eLife, (2016) 5:e19375.

• Dentin Matrix Protein 1 induces membrane expression of VE-cadherin on endothelial cells and inhibits VEGF-induced angiogenesis by blocking VEGFR-2 phosphorylation. S. Pirotte, V. Lamour, V. Lambert, M-L. Alvarez Gonzalez, S. Ormenese, A. Noël, D. Mottet, V. Castronovo and A. Bellahcène. Blood (2011), 117:2515-26.

• Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer. Bellahcène A, Castronovo V, Ogbureke KU, Fisher LW, Fedarko NS. Nature Reviews Cancer (2008), 8 (3) : 212-26.

  5. Runx2- and histone deacetylase 3-mediated repression is relieved in differentiating human osteoblast cells to allow high bone sialoprotein expression. Lamour V, Detry C, Sanchez C, Henrotin Y, Castronovo V and Bellahcène A. Journal of Biological Chemistry, 282 (50) : 36240-9.

• Dentin matrix protein 1 is expressed in human lung cancer. M. Chaplet, L. de Leval, D.

  Waltregny, C. Detry, G. Fornaciari, G. Bevilacqua, L.W. Fisher, V. Castronovo and Bellahcène A. Journal of Bone and Mineral Research (2003), 18,1506-1512.

• Bone sialoprotein mediates human endothelial cell attachment and migration and promotes angiogenesis. Bellahcène A., Bonjean K., Fohr B., Fedarko N.S., Robey F.A., Young M.F., Fisher L.W. and Castronovo V. Circulation Research (2000), 86 (8) : 885-891.

• Prognostic value of bone sialoprotein expression in clinically localized human prostate

  cancer. Waltregny D., Bellahcène A., Van Riet I., Fisher L.W., Young M., Fernandez P., Dewé W., de Leval J. and Castronovo V. Journal of the National Cancer Institute (1998), 90 (13) :1000-1008.

• Expression of bone sialoprotein, a bone matrix protein, in human breast cancer. Bellahcène A., Merville M-P. et Castronovo V. Cancer Research (1994), 54 : 2823-2826.

• 2018-2022

  Novel Connection between Glycation stress and Epigenetic regulation, FNRS-PDR

• 2011-2015

  European Union Framework Programme 7, Marie-Curie (ITN) « BONE-NET »: European Training Network on Cancer induced Bone Disease (N° PITN-GA-2010-264817)

• 2019

  Member of FNRS-FRIA jury

• Member of the Board of Biobank of the University of Liège and Liège University Hospital (Belgium)

• 2011-2018

  Member of the Board of The Belgian Association for Cancer Research

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