Short CV/Education and training

Current positions

  • Since 2012
    Principal Investigator at the Department of Neuroscience, Karolinska Institute, Sweden. Field of study: Mechanisms of neuronal vulnerability and resistance, neuronal specification

  • Since 2011
    Senior scientist, Department of Neuroscience, Karolinska Institute. Field of study: Mechanisms of neuronal vulnerability

  • Since 2011
    Associate professor (Docent) in Neurobiology Karolinska Institute (KI) (Dnr 41/11)

Postdoctoral positions

  • 2001 – 2002
    Postdoc, with Dr Ellen Carpenter, Department of Psychiatry, UCLA School of Medicine, CA USA.
    Field of study: Developmental Neurobiology

  • 2002 – 2006
    Postdoc, with Prof Ole Isacson & Prof Kwang-Soo Kim, Harvard Medical School, McLean Hospital, MA, USA, Field of study: Stem cell specification, regenerative medicine and neurodegenerative diseases

  • 2007 – 2011
    Research Assocociate, with Prof Thomas Perlmann and Prof Johan Ericson, Ludwig Institute for Cancer Research, Stockholm, Sweden. Field of study: Developmental neurobiology, stem cell specification and neurodegenerative diseases

Doctoral degree

  • 2000
    December 15, Doctor of medicine (PhD) in Molecular Endocrinology. Dept of Medical Nutrition, Karolinska Institutet, Sweden. Title of doctoral thesis: "Cytochrome P450 in the brain: Characterization and regulation"

Higher education

  • 1991 – 1995
    B.Sc., Biomedical Chemistry, Linnaeus University
    (ne: University College of Kalmar), Sweden.

Selected publications

  • Hedlund E and Deng Q (2018) Single-cell RNA sequencing: technical advancements and biological applications. Molecular Aspects of Medicine 59:36-46. PMID: 28754496

  • Reber S, Mechtersheimer J, Nasif S, Aguila Benitez J, Colombo M, Domanski M, Jutzi D, Hedlund E and Ruepp MD (2018) CRISPR-Trap: A clean approach for the generation of gene knockouts and gene replacements in human cells. Molecular Biology of the Cell 29(2):75-83. PMID:29167381

  • Mills R, Taylor-Weiner H, Correia JC, Agudelo LZ, Allodi I, Kolonelou C, Martinez-Redondo V, Ferreira DMS, Nichterwitz S, Comley LH, Lundin V, Hedlund E, Ruas JL and Teixeira AI (2018) Neurturin is a PGC-1α1-controlled myokine that promotes motor neuron recruitment and neuromuscular junction formation. Molecular Metabolism 7:12-22. PMID:29157948

  • Nijssen J, Comley LH and Hedlund E (2017) Motor neuron vulnerability and resistance in amyotrophic lateral sclerosis. Acta Neuropathologica 133:863-885 DOI:10.1007/s00401-017-1708-8. PMID: 28409282

  • Nichterwitz S, Chen G, Aguila Benitez J, Storvall H, Yilmaz M, Cao M, Sandberg R, Deng Q and Hedlund E (2016) Laser-capture microscopy coupled with Smart-seq2 (LCM-seq) for precise spatial transcriptome profiling. Nature Communications 7:12139, PMID: 27387371

  • Allodi I, Comley L, Nichterwitz S, Nizzardo M, Simone C, Aguila Benitez J, Cao M, Corti S and Hedlund E (2016) Differential neuronal vulnerability identifies IGF-2 as a protective factor in ALS. Scientific Reports 6:25960. PMID:27180807

  • Hedlund E, Belnoue L, Theofilopoulos S, Salto C, Bye C, Parish C, Deng Q, Kadkhodaei B, Ericson J, Arenas E, Perlmann T and Simon A (2016) Enhancing Lmx1a-expressing midbrain progenitor proliferation and neurogenesis by dopamine receptor antagonists. Scientific Reports 6:26448. PMID: 27246266

  • Comley LH, Nijssen J, Frost-Nylen J and Hedlund E (2016) Cross disease comparison of amyotrophic lateral sclerosis and spinal muscular atrophy reveals conservation of selective vulnerability but differential neuromuscular junction pathology. Journal of Comparative Neurology 524(7):1424-1442 PMID: 26502195

    The article is recommended by Faculty1000: https://f1000.com/prime/725879208



Complete list of publications

Membership in scientific bodies/juries

  • International Society for Stem Cell Research (ISSCR)

    Society for Neuroscience (SFN)

Media coverage

  • http://ki.se/en/news/new-method-allows-analysis-of-single-neurons-from-tissues

  • http://ki.se/en/news/resistant-neurons-point-the-way-to-protective-factors-in-als

  • http://www.alsresearchforum.org/growth-factors-in-als-the-eyes-have-it/

  • http://www.alsresearchforum.org/high-igf-2-in-the-oculomotor-neurons-may-underlie-disease-resistance-als/

Soft Skills/Other activities and achievements

Soft Skills

  • Track and field coach


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