Short CV/Education and training

Current positions

  • Since 2012
    Principal Investigator at the Department of Neuroscience, Karolinska Institute, Sweden. Field of study: Mechanisms of neuronal vulnerability and resistance, neuronal specification

  • Since 2011
    Senior scientist, Department of Neuroscience, Karolinska Institute. Field of study: Mechanisms of neuronal vulnerability

  • Since 2011
    Associate professor (Docent) in Neurobiology Karolinska Institute (KI) (Dnr 41/11)

Postdoctoral positions

  • 2001 – 2002
    Postdoc, with Dr Ellen Carpenter, Department of Psychiatry, UCLA School of Medicine, CA USA.
    Field of study: Developmental Neurobiology

  • 2002 – 2006
    Postdoc, with Prof Ole Isacson & Prof Kwang-Soo Kim, Harvard Medical School, McLean Hospital, MA, USA, Field of study: Stem cell specification, regenerative medicine and neurodegenerative diseases

  • 2007 – 2011
    Research Assocociate, with Prof Thomas Perlmann and Prof Johan Ericson, Ludwig Institute for Cancer Research, Stockholm, Sweden. Field of study: Developmental neurobiology, stem cell specification and neurodegenerative diseases

Doctoral degree

  • 2000
    December 15, Doctor of medicine (PhD) in Molecular Endocrinology. Dept of Medical Nutrition, Karolinska Institutet, Sweden. Title of doctoral thesis: "Cytochrome P450 in the brain: Characterization and regulation"

Higher education

  • 1991 – 1995
    B.Sc., Biomedical Chemistry, Linnaeus University
    (ne: University College of Kalmar), Sweden.

Selected publications

  • Hedlund E and Deng Q (2018) Single-cell RNA sequencing: technical advancements and biological applications. Molecular Aspects of Medicine 59:36-46. PMID: 28754496

  • Reber S, Mechtersheimer J, Nasif S, Aguila Benitez J, Colombo M, Domanski M, Jutzi D, Hedlund E and Ruepp MD (2018) CRISPR-Trap: A clean approach for the generation of gene knockouts and gene replacements in human cells. Molecular Biology of the Cell 29(2):75-83. PMID:29167381

  • Mills R, Taylor-Weiner H, Correia JC, Agudelo LZ, Allodi I, Kolonelou C, Martinez-Redondo V, Ferreira DMS, Nichterwitz S, Comley LH, Lundin V, Hedlund E, Ruas JL and Teixeira AI (2018) Neurturin is a PGC-1α1-controlled myokine that promotes motor neuron recruitment and neuromuscular junction formation. Molecular Metabolism 7:12-22. PMID:29157948

  • Nijssen J, Comley LH and Hedlund E (2017) Motor neuron vulnerability and resistance in amyotrophic lateral sclerosis. Acta Neuropathologica 133:863-885 DOI:10.1007/s00401-017-1708-8. PMID: 28409282

  • Nichterwitz S, Chen G, Aguila Benitez J, Storvall H, Yilmaz M, Cao M, Sandberg R, Deng Q and Hedlund E (2016) Laser-capture microscopy coupled with Smart-seq2 (LCM-seq) for precise spatial transcriptome profiling. Nature Communications 7:12139, PMID: 27387371

  • Allodi I, Comley L, Nichterwitz S, Nizzardo M, Simone C, Aguila Benitez J, Cao M, Corti S and Hedlund E (2016) Differential neuronal vulnerability identifies IGF-2 as a protective factor in ALS. Scientific Reports 6:25960. PMID:27180807

  • Hedlund E, Belnoue L, Theofilopoulos S, Salto C, Bye C, Parish C, Deng Q, Kadkhodaei B, Ericson J, Arenas E, Perlmann T and Simon A (2016) Enhancing Lmx1a-expressing midbrain progenitor proliferation and neurogenesis by dopamine receptor antagonists. Scientific Reports 6:26448. PMID: 27246266

  • Comley LH, Nijssen J, Frost-Nylen J and Hedlund E (2016) Cross disease comparison of amyotrophic lateral sclerosis and spinal muscular atrophy reveals conservation of selective vulnerability but differential neuromuscular junction pathology. Journal of Comparative Neurology 524(7):1424-1442 PMID: 26502195

    The article is recommended by Faculty1000:

Complete list of publications

Membership in scientific bodies/juries

  • International Society for Stem Cell Research (ISSCR)

    Society for Neuroscience (SFN)

Media coverage





Soft Skills/Other activities and achievements

Soft Skills

  • Track and field coach


You can only see the contact information of the academics in the database if you are a registered user of AcademiaNet.
Please register here


  1. Read what our members say about AcademiaNet.

Follow us

No more excuses!

  1. Please download the brochure "No more excuses" and read more about female experts in Europe, and about AcademiaNet.

Similar profiles

  1. Prof. Anne Angelillo-Scherrer

    Biological and related sciences, Health, Internal medicine, Hematology - hemostasis, Clinical laboratory sciences - hematology

  2. Prof. Patrizia Agostinis

    Biological and related sciences, Health, Cell Biology, Cellular signaling, Cancer biology, Cancer therapy

  3. Prof. Dr. Myriam Aouadi

    Health, Obesity, Diabetes, Immunology

  4. Prof. Dr. Katrin Amunts

    Health, Brain research

Academia Net