Dr. A.I. den Hollander

• 1996 – 2001
  PhD student, Department of Human Genetics, Radboud University Nijmegen Medical Centre, the Netherlands
  
  

• 2001 – 2002
  Postdoctoral researcher, Department of Human Genetics, Radboud University Nijmegen Medical Centre, the Netherlands
  
  

• 2002
  Guest researcher, Téléthon Institute of Genetics and Medicine (TIGEM), Naples, Italy
  
  

• 2002 – 2007
  Senior research scientist, Department of Human Genetics, Radboud University Nijmegen Medical Centre, the Netherlands
  
  

• 2007 – 2008
  Research fellow, The Berman-Gund Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA
  
  

• 2008 – 2009
  Assistant professor, Department of Ophthalmology, Radboud University Nijmegen Medical Centre, the Netherlands
  
  

• Since 2009
  Associate professor, Departments of Ophthalmology (90%) and Human Genetics (10%), Radboud University Nijmegen Medical Centre, the Netherlands
  
  

• Den Hollander AI, Koenekoop RK, Mohamed MD, Arts HH, Boldt K, Towns KV, Sedmak T, Beer M, Nagel-Wolfrum K, McKibbin M, Dharmaraj S, Lopez I, Ivings L, Williams GA, Springell K, Woods CG, Jafri H, Rashid Y, Strom TM, van der Zwaag B, Gosens I, Kersten FFJ, van Wijk E, Veltman JA, Zonneveld MN, van Beersum SEC, Maumenee IH, Wolfrum U, Cheetham ME, Ueffing M, Cremers FPM, Inglehearn CF, Roepman R. (2007) Mutations in LCA5, encoding the ciliary protein lebercilin, cause Leber congenital amaurosis. Nature Genet 39:889-895. (impact factor 32.7)

• Den Hollander AI, ten Brink JB, de Kok YJM, van Soest S, van den Born LI, van Driel MA, van de Pol DJR, Payne AM, Bhattacharya SS, Kellner U, Hoyng CB, Westerveld A, Brunner HG, Bleeker-Wagemakers EM, Deutman AF, Heckenlively JR, Cremers FPM, Bergen AAB. (1999) Mutations in a human homologue of Drosophila crumbs cause retinitis pigmentosa (RP12). Nature Genet 23:217-221. (impact factor: 32.7)

• Den Hollander AI, Black A, Bennett J, Cremers FPM. (2010) Lighting a candle in the dark: advances in genetics and gene therapy of recessive retinal dystrophies. J Clin Invest 120:3042-3053. (impact factor 16.6)

• Ozgul RK, Siemiatkowska AM, Yucel D, Myers CA, Collin RW, Zonneveld MN, Beryozkin A, Banin E, Hoyng CB, van den Born LI, European Retinal Disease Consortium, Bose R, Shen W, Sharon D, Cremers FPM, Klevering BJ, den Hollander AI, Corbo JC. Exome sequencing and cis-regulatory mapping identify mutations in MAK, a gene encoding a regulator of ciliary length, as a cause of retinitis pigmentosa. Am J Hum Genet 89:253-264. (IF 12.3)

• Bandah-Rozenfeld D, Collin RW, Banin E, van den Born LI, Coene KL, Siemiatkowska AM, Zelinger L, Khan MI, Lefeber DJ, Erdinest I, Testa F, Simonelli F, Voesenek K, Blokland EA, Strom TM, Klaver CC, Qamar R, Banfi S, Cremers FPM, Sharon D, den Hollander AI. (2010) Mutations in IMPG2, encoding interphotoreceptor matrix proteoglycan 2, cause autosomal recessive retinitis pigmentosa. Am J Hum Genet 87:199-208. (impact factor 12.3)

• Wang H, den Hollander AI, Moayedi Y, Abulimiti A, Li Y, Collin RW, Hoyng CB, Lopez I, Bray M, Lewis RA, Lupski JR, Mardon G, Koenekoop RK, Chen R. (2009) SPATA7 is an early onset retinal disease gene. Am J Hum Genet 84:380-397. (impact factor 12.3)

• Thiadens AA, den Hollander AI, Roosing S, Nabuurs SB, Zekveld-Vroon RC, Collin RW, De Baere E, Koenekoop RK, van Schooneveld MJ, Strom TM, van Lith-Verhoeven JJ, Lotery AJ, van Moll-Ramirez N, Leroy BP, van den Born LI, Hoyng CB, Cremers FPM, Klaver CC. (2009) Homozygosity mapping reveals PDE6C mutations in patients with early-onset cone photoreceptor disorders. Am J Hum Genet 85:240-247. (impact factor 12.3)

• Boon CJF, Klevering BJ, Hoyng CB, Zonneveld-Vrieling MN, Nabuurs SB, Blokland E, Cremers FPM, den Hollander AI. (2008) Basal laminar drusen caused by compound heterozygous variants in the CFH gene. Am J Hum Genet 82:516-523. (impact factor 12.3)

• Collin RWJ, Littink KW, Klevering BJ, van den Born LI, Koenekoop RK, Zonneveld MN, Blokland EAW, Strom TM, Hoyng CB, den Hollander AI, Cremers FPM. (2008) Identification of a 2-megabases human orthologue of Drosophila eyes shut/spacemaker that is mutated in patients with retinitis pigmentosa. Am J Hum Genet 83:594-603. (impact factor 12.3)

• Den Hollander AI, Koenekoop RK, Yzer S, Lopez I, Arends ML, Voesenek KEJ, Zonneveld MN, Strom TM, Meitinger T, Brunner HG, Hoyng CB, van den Born LI, Rohrschneider K, Cremers FPM. (2006) Mutations in the CEP290 (NPHP6) gene are a frequent cause of Leber congenital amaurosis. Am J Hum Genet 79:556-561. (impact factor 12.3)

• ERC Starting Grant, European Research Council (ERC). Closing in on missing heritability and immune dysregulation in age-related macular degeneration. A.I. den Hollander, 2013 – 2018, €1,500,00.

• VIDI Innovational Research Award, Netherlands Organization for Scientific Research (NWO). Elucidation of the molecular basis of basal laminar drusen and its predisposing role in age-related macular degeneration. A.I. den Hollander, 2008 – 2014, €600,000.

• VENI Innovational Research Award, Netherlands Organization for Scientific Research (NWO). Ophthalmogenomics: a new genome-wide approach for inherited blindness. A.I. den Hollander, 2005 – 2008, €260,000.

• Member of the Annual Meeting Program Committee, The Association for Research in Vision and Ophthalmology (ARVO, world's largest vision research conference in the world with 12,000 attendees), 2009 – 2012

• Member of the TOP-grant review committee, Netherlands Organisation for Scientific Research (NWO), 2011 – 2015

• Member of the VENI award review committee, Netherlands Organisation for Scientific Research (NWO), 2011

• Editorial Board Member, PLoS ONE, since 2011

• Editorial Board Member, Molecular Vision, since 2011

• Editorial Board Member, Human Genomics, since 2011

• Member of the UMC Fellowship committee, Radboud University Nijmegen Medical Centre, since 2011

• Member of the selection/interview committee for the topmaster's Molecular Mechanisms of Disease (MMD), Radboud University Nijmegen Medical Centre, since 2011

• Board member of female network FOCUS, Radboud University Nijmegen Medical Centre, since 2011

Other activities and achievements/family

• 2 children (born 2004 and 2007)

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