Short CV/Education and training

Education and qualifications

  • 1984
    Ecole Normale Superieure in Paris

  • 1990
    PhD in Life Sciences, University of Paris VI

  • 1998
    HDR Biology Research, University Paris XI

Training and professional experience

  • 1991 – 1994
    Post-doc at the Swiss Institute for Research against Cancer (L. Kuhn, Lausanne) and the European Molecular Biology Laboratory (I. Mattaj, Heidelberg, Germany)

  • 1994
    Recruitment as a permanent staff scientist at the CNRS. Laureat of ATIPE "Cell Biology" Young investigator Program

  • 1995 – 2000
    Junior group leader at the Institut Curie

  • Since 2000
    Group leader at the Institut Jacques Monod

  • 2007 – 2008
    Auditor of IHEST

Responsibility currently held

    Director of Research CNRS

    Co-director of the Lab of Excellence "WhoAmI?" coordinating 27 research teams

    Group leader

Selected publications

  • Dargemont, C., Dunon, D., Deugnier, M.A., Denoyelle, M., Girault, J.M., Lederer, F., Le, K.H.D., Godeau, F., Thiery, J.P. and Imhof, B.A. (1989). Thymotaxin, a chemotactic protein, is identical to ? 2-microglobulin. Science 246, 802-806.

  • Dargemont, C. and Kuhn, L.C. (1992). Export of mRNA from microinjected nuclei of Xenopus laevis oocytes. J. Cell Biol. 118, 1-9.

  • Schmidt-Zachmann, M.S.*, Dargemont, C.*, Kuhn, L.C. and Nigg, E.A. (1993). Nuclear export of proteins: The role of nuclear retention. Cell 74, 494-504. (*Co-first authors)

  • Ossareh-Nazari, B., Bachelerie, F. and Dargemont, C.(1997) Evidence for a role of CRM1 in signal-mediated nuclear protein export. Science. 278, 141-144.

  • Cohen, M, Stutz, F., Belgareh, N., Haguenauer-Tsapis, R. and Dargemont, C. (2003) Ubp3p requires a co-factor, Bre5p, to specifically de-ubiquitinate the COPII protein, Sec23p. Nature Cell Biology.5 (7) : 661-667. (cited by F1000)

  • Gwizdek, C*., Iglesias*, N., Rodriguez, M.S., Ossareh-Nazari, B, Hobeika, M., Divita, G., Stutz, F. and Dargemont C. (2006) Ubiquitin-Associated domain of Mex67 synchronizes recruitment of the mRNA export machinery with transcription. PNAS 103(44):16376-81

  • Vitaliano, A., Menant, A., Hobeika, M., Géli, V., Gwizdek, C. and Dargemont, C. (2008) Ubiquitylation of the COMPASS component Swd2 links H2B ubiquitylation to H3K4 trimethy-lation. Nature Cell Biology 10(11):1365-1371.

  • Iglesias, N., Tutucci, E., Gwizdek, C., Vinciguerra, P., Von Dach E., Corbett, A., Dargemont, C. and Stutz, F. (2010) Ubiquitin-mediated mRNP dynamics and surveillance prior to budding yeast mRNA export. Genes and Dev. Sep 1;24(17):1927-38.

  • Dokudovskaya S, Waharte F, Schlessinger A, Pieper U, Devos DP, Cristea IM, Williams R, Salamero J, Chait BT, Sali A, Field MC, Rout MP, Dargemont C. (2011) A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in yeast. Mol. Cell Proteomics. 10(6):M110.006478.

  • Vitaliano-Prunier, A*., Babour A.*, Hérissant, L.*, Apponi, L., Margaritis, T., Holstege, FCP, Corbett, AH, Gwizdek, C.* and Dargemont, C.* (2012) H2B ubiquitylation controls the formation of export-competent mRNP. Mol Cell. 1:132-139.

  • Hayakawa, A., Babour, A., Sengmanivong, L. and Dargemont, C. (2012) Ubiquitylation of the nuclear pore complex controls nuclear migration during mitosis in S. cerevisiae. J. Cell Biol. 1:19-27.

  • Margaritis, T., Oreal, V., Brabers, N., Maestroni, L., Vitaliano-Prunier, A., van Hooff, S., van Leenen, D., Dargemont, C*., Géli V*., Holstege, F*. Dimethymethyletion of H3K4 by Set1 represses transcription of a subset of coding genes by promoting 3?-end antisense RNA production. PLoS Genetics. 8(9): e1002952. doi:10.1371/journal.pgen.1002952

Membership in scientific bodies/juries

Since 2006

  • Scientific delegate AERES (French agency for evaluation), 2009 – 2013

  • Member of the Scientific Board of the Paris Descartes University, since 2012

  • Member of IUF committee, 2009 – 2012

  • Editorial Board of Biology of the Cell, since 2012

  • Member of the ATIP "Molecular Biology" Young investigator Program – international evaluation committee, since 2013

  • Member of the ATIP-Cell and Developmental Biology- Young investigator Program – international evaluation committee, 2008 – 2012

  • Deputy Scientific Director of the Department "Life Sciences" of the CNRS, 2006 – 2007

  • Chair of Scientific committee on Cell and developmental Biology and member of the Scientific Board of ARC (French Association against Cancer), 2006 – 2011

Soft Skills/Other activities and achievements

Other activities and achievements/family

  • Married, two children


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