Prof. Lital Alfonta
Biological and related sciences, Physical sciences, Bioelectrochemistry, Synthetic Biology, Chemical Biology
Biological and related sciences
Neuroscience / Development
synapse / synaptogenesis / synaptic plasticity / human evolution / postsynaptic scaffold
2020 Coup d’Elan award, Bettencourt-Schueller foundation
2019 EMBO young investigator award.
Janine Courrier award de l’Académie des Sciences.
2018 ERC starting grant.
Gemin O, Serna P, Zamith J, Assendorp N, Fossati M, Rostaing P, Triller A and Charrier C, Unique properties of dually innervated dendritic spines in pyramidal neurons of the somatosensory cortex uncovered by 3D correlative light and electron microscopy, Plos Biology, in press.
Fossati M, Charrier C, Trans-synaptic interactions of ionotropic glutamate receptors (2020) Curr Opin Neurobiol, 66:85-92.
Fossati M, Assendorp N, Gemin O, Colasse S, Dingli F, Arras G, Loew D and Charrier C, Tans-synaptic signaling via the glutamate receptor delta-1 mediates inhibitory synapse formation in cortical pyramidal neurons (2019) Neuron, 104(6):1081-1094.e7.
Maffei A, Charrier C, Caiati M, Barberis A, Mahadevan V, Woodin M and Tyagarajan SK, Emerging mechanisms underlying dynamics of GABAergic synapses (2017) J Neurosci, 37(45): 10792–10799.
Fossati M, Pizzarelli R, Schmidt ER, Kupferman JV, Stroebel D, Polleux F, Charrier C, SRGAP2 and its human-specific paralog co-regulate the development of excitatory and inhibitory synapses (2016) Neuron, 91(2):356-69.
Charrier C and Polleux F, How human-specific SRGAP2 gene duplications control human brain development (2012) Médecine/Sciences, 28(11):911-4.
Charrier C, Joshi K, Coutinho-Budd J, Kim JE, Lambert N, de Marchena J, Jin WL, Vanderhaeghen P, Ghosh A, Sassa T and Polleux F, Inhibition of SRGAP2 by its human-specific paralogs induces neoteny during spine maturation (2012) Cell, 149(4):923-35.
Charrier C, Machado P, Tweedie-Cullen RY, Rutishouser D, Mansuy IM and Triller A, A crosstalk between β1 and β3 integrins controls glycine receptor and gephyrin trafficking at synapses (2010) Nature Neuroscience, 13(11):1388-95.
Lévi S, Schweizer C, Bannai H, Pascual O, Charrier C, Triller A, Homeostatic regulation of synaptic GlyR numbers driven by lateral diffusion (2008) Neuron, 59(2):261-73
Charrier C, Ehrensperger MV, Dahan M, Lévi S, Triller A, Cytoskeleton regulation of glycine receptor number at synapses and diffusion in the plasma membrane (2006) J Neurosci, 26:8502-11.
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Biological and related sciences, Physical sciences, Bioelectrochemistry, Synthetic Biology, Chemical Biology
Biological and related sciences, Cell Biology, Molecular Biology, Biochemistry, Microscopy
Biological and related sciences, cell biology, molecular biology, biomedicine
Biological and related sciences, Health, Cell Biology, Cellular and Molecular Neuroscience, Vascular Biology, Tumour Biology