Short CV/Education and training

  • I am a Wellcome Trust Research Career Development Fellow. I develop and apply statistical methods with the aim of understanding the genetics and mechanisms of common complex disease. My earlier research focused on quantifying genetic heritability and the use of linkage and association methods to localise genetic variants for complex disease (hypertension, type 1 diabetes and leprosy). As the number of regions convincingly associated with disease has grown, I have become increasingly interested in the use of gene expression data to identify the molecular mechanisms underlying these associations. The work of my group in the Diabetes and Inflammation Laboratory (DIL) covers analysis of genetic, flow cytometry, microarray and sequencing data. I am particularly interested in using allele specific expression to detect genetic effects on gene expression in small samples of sorted cell populations and in integrating genetic results for multiple traits to identify and understand pleitropic effects, which may help us understand the molecular mechanisms underlying disease associations.

Selected publications

  • Giambartolomei C, Vukcevic D, Schadt EE, Hingorani AD, Wallace C, and Plagnol V. Bayesian test for co-localisation between pairs of genetic association studies using summary statistics. under review, 2013.

  • Wallace C. Unbiased statistical testing of shared genetic control for potentially related traits. Genet Epidemiol, in press.

  • Yang X, Todd JA, Clayton D, and Wallace, C. Extra-binomial variation approach for analysis of pooled DNA sequencing data. Bioinformatics, 28:2898-2904, 2012.

  • Wallace, C, Rotival M, Cooper JD, Rice CM, Yang JHM, McNeill M, Smyth DJ, Niblett D, Cambien F, CC, Tiret L, Todd JA, Clayton DG, and Blankenberg S. Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes. Hum Mol Genet, 21:2815-2824, 2012.

  • Davison, L, Wallace, C, Cooper JD, Cope NF, Wilson NK, Smyth DJ, Howson JMM, Saleh N, Al-Jeffery A, Angus KL, Stevens HE, Nutland S, Duley S, Coulson RMR, Walker NM, Burren OS, Rice CM, Cambien F, Zeller T, Munzel T, Lackner K, Blankenberg S, CC, Fraser P, Gottgens B, and Todd JA. Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene. Hum Mol Genet, 21:322-333, 2012.

  • Wallace C, Smyth DJ, Maisuria-Armer M, Walker NM, Todd JA, and Clayton DG. The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. Nat Genet, 42:68-71, 2010.

  • Heinig M, Petretto E, Wallace C, Bottolo L, Rotival M, Lu H, Li Y, Sarwar R, Langley SR, Bauerfeind A, Hummel O, Lee YA, Paskas S, Rintisch C, Saar K, Cooper J, Buchan R, Gray EE, Cyster JG, Consortium C, Erdmann J, Hengstenberg C, Maouche S, Ouwehand WH, Rice CM, Samani NJ, Schunkert H, Goodall AH, Schulz H, Roider HG, Vingron M, Blankenberg S, Münzel T, Zeller T, Szymczak S, Ziegler A, Tiret L, Smyth DJ, Pravenec M, Aitman TJ, Cambien F, Clayton D, Todd JA, Hubner N, and Cook SA. A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature, 467:460-464, 2010.

  • Downes K, Pekalski M, Angus KL, Hardy M, Nutland S, Smyth DJ, Walker NM, Wallace C, and Todd JA. Reduced expression of IFIH1 is protective for type 1 diabetes. PLoS One, 5, 2010.

Complete list of publications


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