Short CV/Education and training

  • In my lab at the Weizmann Institute of Science, my research passion is to understand human genome regulation by the development and application of novel single-molecule-based technologies to visualize the epigenome.

  • During my scientific career, I was often frustrated with the limited technologies available for studying chromatin, which impede systematic and mechanistic understanding of the combinatorial action of epigenetic marks in specifying distinct biological processes. I, therefore, dedicated my postdoctoral studies at Massachusetts General Hospital and Harvard Medical School to develop a novel technology, based on single-molecule imaging, for exploring the histone code. In the lab, we aim to decipher the complex network of epigenetic marks underlying chromatin behavior, and how these marks inter-relate and function in specifying distinct cell types. We also seek to understand aberrant chromatin regulation in cancer and, in this context, how we can leverage the high sensitivity and high-throughput epigenetic profiling for clinical applications.

Selected publications

  • Shema E, Jones D, Shoresh N, Donohue L, Ram O, Bernstein BE. (2016). Single-molecule decoding of combinatorially modified nucleosomes. Science 352(6286): 717-21. DOI: 10.1126/science.aad7701.

  • Shema E, Bernstein BE and Buenrostro JD (2019). Single-cell and single-molecule epigenomics: genome-regulation and cellular diversity at unprecedented resolution. Nature Genetics 51(1):19-25. doi: 10.1038/s41588-018-0290-x.

  • Shema-Yaacoby E*, Nikolov M*, Haj-Yahya M, Siman P, Allemand E, Yamaguchi Y, Muchardt C, Urlaub H, Brik A, Oren M, Fischle W. (2013). Systematic identification of proteins binding to chromatin-embedded ubiquitylated H2B reveals recruitment of SWI/SNF to regulate transcription. Cell Reports 4(3):601-8. DOI: 10.1016/j.celrep.2013.07.014. * – Equal co-authors.

  • Shema E, Kim J, Roeder RG and Oren M. (2011). RNF20 inhibits TFIIS-facilitated transcriptional elongation to suppress pro-oncogenic gene expression. Molecular Cell 42(4), 477-488. DOI: 10.1016/j.molcel.2011.03.011.

  • Shema E, Tirosh I, Aylon Y, Huang J, Ye C, Moskovits N, Raver-Shapira N, Minsky N, Pirngruber J, Tarcic G, Hublarova P, Moyal L, Gana-Weisz M, Shiloh Y, Yarden Y, Johnsen SA, Vojtesek B, Berger SL, Oren M. (2008). The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression. Genes & Development 22, 2664-2676. DOI: 10.1101/gad.1703008.

Complete list of publications


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