PhD Mar Albà
Biological and related sciences, Evolution, genomics, bioinformatics
Biological and related sciences
Molecular Biology, Molecular Genetics, Biochemistry
DNA damage response, Ubiquitination, Chromatin – Epigenetics, Hematopoietic stem cells, Cancer, Stem Cells
Habilitation to function as professor in Italian universities in: Molecular Biology (05/E2 BIO11, Full), Applied Biology (05/F1 BIO13, Associate and Full)
MIUR – The Italian Minister of Education, Universities and Research, 2018
Habilitation to function as professor in Italian universities in: Molecular Biology (05/E2 BIO11, Associate), 2018
Dutch Cancer Society-Koningin Wilhelmina Fonds (KWF) Kankerbestrijding project grant, 2012
Vidi-laureaat, Vidi individual award (Innovational Research Incentives Scheme) from the Netherlands Organization for Scientific Research (NWO), 2008 – 2013
ASPASIA Award from the Netherlands Organization for Scientific Research (NWO), 2008
Dutch Cancer Society-Koningin Wilhelmina Fonds (KWF) Kankerbestrijding project grant, 2007
Dutch, English, Italian
DNA damage tolerance in hematopoietic stem and progenitor cells in mice. Pilzecker B, Buoninfante OA, van den Berk P, Lancini C, Song JY, Citterio E, Jacobs H. Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E6875-E6883. Doi: 10.1073/pnas.1706508114. Epub 2017 Jul 31.
Polycomb repressive complex-2 is a barrier to Kras-driven inflammation and epithelial mesenchymal transition in non-small cell lung cancer. Serresi M, Gargiulo G, Proost N, Siteur B, Cesaroni M, Koppens M, Xie H, Sutherland KD, Hulsman D, Citterio E, Orkin S, Berns A, and van Lohuizen M. Cancer Cell 2016 Jan 11;29(1):17-31.
Fine tuning the ubiquitin code at DNA double–strand breaks: deubiquitinating enzymes at work. Citterio E. Front. Genet. 2015 Sep 8;6:282
Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells. Lancini C, van den Berk P, Vissers JHA, Gargiulo G, Song J-Y, Hulsman D, Tanger E, Vens C, van Lohuizen M, Jacobs H, and Citterio E. J. Exp. Med. 2014 Aug 25;211(9):1759-77.
Emerging role of Polycomb repressors in the response to DNA damage. Vissers J.H.A., van Lohuizen M., Citterio E.. J.Cell Science. 2012 Sep 1;125(17):3939-48.
RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling. Mattiroli F., Vissers J.H.A., van dijk W.J., Ipka P., Citterio E., Vermeulen W., Marteijn J.A., Sixma T. Cell. 2012 Sep 14;150(6).
The many faces of ubiquitinated histone H2A: insights from the DUBs.Vissers JH, Nicassio F, van Lohuizen M, Di Fiore PP, Citterio E. Cell Div. 2008 Apr 22;3:8.
Human USP3 is a chromatin modifier required for S-phase progression and genome stability. Nicassio F., N. Corrado, J. H.A. Vissers, L. Areces, S. Bergink, J. Martijn, B. Geverts, A. B. Houtsmuller, W. Vermeulen, P. P. Di Fiore and E. Citterio. Current Biology. 2007. Nov 20;17(22):1972-7
DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. Bergink S., F.A. Salomons, D. Hoogstraten, T.A.M. Groothuis, H. de Waard, J. Wu, L. Yuan, E. Citterio, A.B. Houtsmuller, J. Neefjes, J.H. J. Hoeijmakers, W. Vermeulen and N.P. Dantuma. Genes Dev. 2006 May 15;20(10):1343-52.
Np95 Is a Histone-Binding Protein Endowed with Ubiquitin Ligase Activity. Citterio E., R. Papait , F. Nicassio, M. Vecchi, P. Gomiero, R. Mantovani, P.P. Di Fiore and I.M. Bonapace. Mol. Cell. Biol. 2004 Mar 15;24(6):2526-2535.
DNA damage stabilizes interaction of CSB with the transcription elongation machinery. van den Boom V #, E. Citterio#, D. Hoogstraten, A. Zotter, J.M. Egly, W.A. van Cappellen, J.H. Hoeijmakers, A.B. Houtsmuller, W. Vermeulen. J. Cell Biol. 2004 Jul 5;166(1):27-36.
ATP-dependent chromatin remodeling by the Cockayne syndrome B DNA repair-transcription coupling factor. Citterio, E., V. van den Boom, G. Schnitzler, , R. Kanaar, E. Bonte, R.E. Kingston, J.H.J. Hoeijmakers and W. Vermeulen. Mol. Cell. Biol. 2000 Oct 20: 7643-7653
Transcriptional healing. Citterio, E., W. Vermeulen and J.H.J. Hoeijmakers. Cell 2000 May 101:447-450.
Biochemical and biological characterization of wild type and ATPase-deficient Cockayne syndrome B repair protein.Citterio, E., S. Rademakers, G.T. van der Horst, A.J. van Gool, J.H.J. Hoeijmakers and W. Vermeulen. J. Biol. Chem. 1998
The Cockayne syndrome B protein, involved in transcription-coupled DNA repair, resides in an RNA polymerase II-containing complex. van Gool#, A.J., E. Citterio#, S. Rademakers, R. van Os, W. Vermeulen, A. Constantinou, J.M. Egly, D. Bootsma and J.H.J. Hoeijmakers. EMBO J. 1997 Oct 16:5955-5965.
In vivo RNAi screens for regulators of ubiquitin-mediated DNA damage response in mouse hematopoietic stem cells (HSCs)
(De)ubiquitinating enzymes networks in the regulation of DNA damage response pathways
Silencing of DNA damage signaling by USP3 deubiquitinating enzyme: molecular mechanism and role in tumor suppression
Maintenance of genome integrity by histone(de)ubiquitinating enzymes
Reviewer for: Nature Medicine, Nature Communications, Journal of Experimental Medicine, Nucleic Acid Research, Journal of Cell Science, The International Journal of Biochemistry & Cell Biology, Oncotarget, Experimental Hematology, Genome Biology and Evolution.
Reviewer: The French National Cancer Institute (INCa); Cancer Research UK
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Biological and related sciences, Evolution, genomics, bioinformatics
Biological and related sciences, Environment, Plant Ecology, Conservation Biology, Landscape Genomics
Biological and related sciences, Cell Biology, Molecular Biology, Biochemistry, Microscopy
Biological and related sciences, Evolutionary biology, Animal behaviour, Gender studies, Science studies
Cancer can occur when things go wrong in our genes, but also occur when the processes to fix damaged genes goes wrong. AcademiaNet members Dr. Elisabetta Citterio, Dr. Michela Di Virgilio (photo), Dr. Jacqueline Jacobs and Prof. Rocio Sotillo study the mechanisms of DNA repair.