Short CV/Education and training

  • 2009
    EMBO Laboratory Management Course, Heidelberg

  • Since 2008
    Principal Investigator-Research associate – Vidi laureate, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

  • 2008
    - 2013 Vidi Fellow – Principal Investigator – Research associate, The Netherlands Cancer Institute, Amsterdam

  • 2008
    Utrecht University, Laboratory Animals Handling Course (Art.9), Utrecht

  • 2006 – 2008
    Senior post doc, Department of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands

  • 2001 – 2006
    Postdoc, IFOM-IEO campus, Milan, Italy

  • 2000 – 2001
    Postdoc, Department of Cell Biology and Genetics, Erasmus University of Rotterdam, The Netherlands

  • 2000
    PhD Molecular Genetics, Erasmus University of Rotterdam, The Netherlands. Thesis title: Cockayne syndrome B protein: connection between repair, transcription and chromatin structure

  • 1995 – 2000
    PhD student, Department of Cell Biology and Genetics, Erasmus University of Rotterdam, The Netherlands

  • 1993 – 1995
    Junior scientist, DIBIT, S.Raffaele Scientific Institute, Milan, Italy

  • 1993
    Msc Biological Sciences, Universita' degli Studi di Milano, Milan, Italy

Selected publications

  • DNA damage tolerance in hematopoietic stem and progenitor cells in mice. Pilzecker B, Buoninfante OA, van den Berk P, Lancini C, Song JY, Citterio E, Jacobs H. Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E6875-E6883. Doi: 10.1073/pnas.1706508114. Epub 2017 Jul 31.

  • Polycomb repressive complex-2 is a barrier to Kras-driven inflammation and epithelial mesenchymal transition in non-small cell lung cancer. Serresi M, Gargiulo G, Proost N, Siteur B, Cesaroni M, Koppens M, Xie H, Sutherland KD, Hulsman D, Citterio E, Orkin S, Berns A, and van Lohuizen M. Cancer Cell 2016 Jan 11;29(1):17-31.

  • Fine tuning the ubiquitin code at DNA double–strand breaks: deubiquitinating enzymes at work. Citterio E. Front. Genet. 2015 Sep 8;6:282

  • Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells. Lancini C, van den Berk P, Vissers JHA, Gargiulo G, Song J-Y, Hulsman D, Tanger E, Vens C, van Lohuizen M, Jacobs H, and Citterio E. J. Exp. Med. 2014 Aug 25;211(9):1759-77.

  • Emerging role of Polycomb repressors in the response to DNA damage. Vissers J.H.A., van Lohuizen M., Citterio E.. J.Cell Science. 2012 Sep 1;125(17):3939-48.

  • RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling. Mattiroli F., Vissers J.H.A., van dijk W.J., Ipka P., Citterio E., Vermeulen W., Marteijn J.A., Sixma T. Cell. 2012 Sep 14;150(6).

  • The many faces of ubiquitinated histone H2A: insights from the DUBs.Vissers JH, Nicassio F, van Lohuizen M, Di Fiore PP, Citterio E. Cell Div. 2008 Apr 22;3:8.

  • Human USP3 is a chromatin modifier required for S-phase progression and genome stability. Nicassio F., N. Corrado, J. H.A. Vissers, L. Areces, S. Bergink, J. Martijn, B. Geverts, A. B. Houtsmuller, W. Vermeulen, P. P. Di Fiore and E. Citterio. Current Biology. 2007. Nov 20;17(22):1972-7

  • DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. Bergink S., F.A. Salomons, D. Hoogstraten, T.A.M. Groothuis, H. de Waard, J. Wu, L. Yuan, E. Citterio, A.B. Houtsmuller, J. Neefjes, J.H. J. Hoeijmakers, W. Vermeulen and N.P. Dantuma. Genes Dev. 2006 May 15;20(10):1343-52.

  • Np95 Is a Histone-Binding Protein Endowed with Ubiquitin Ligase Activity. Citterio E., R. Papait , F. Nicassio, M. Vecchi, P. Gomiero, R. Mantovani, P.P. Di Fiore and I.M. Bonapace. Mol. Cell. Biol. 2004 Mar 15;24(6):2526-2535.

  • DNA damage stabilizes interaction of CSB with the transcription elongation machinery. van den Boom V #, E. Citterio#, D. Hoogstraten, A. Zotter, J.M. Egly, W.A. van Cappellen, J.H. Hoeijmakers, A.B. Houtsmuller, W. Vermeulen. J. Cell Biol. 2004 Jul 5;166(1):27-36.

  • ATP-dependent chromatin remodeling by the Cockayne syndrome B DNA repair-transcription coupling factor. Citterio, E., V. van den Boom, G. Schnitzler, , R. Kanaar, E. Bonte, R.E. Kingston, J.H.J. Hoeijmakers and W. Vermeulen. Mol. Cell. Biol. 2000 Oct 20: 7643-7653

  • Transcriptional healing. Citterio, E., W. Vermeulen and J.H.J. Hoeijmakers. Cell 2000 May 101:447-450.

  • Biochemical and biological characterization of wild type and ATPase-deficient Cockayne syndrome B repair protein.Citterio, E., S. Rademakers, G.T. van der Horst, A.J. van Gool, J.H.J. Hoeijmakers and W. Vermeulen. J. Biol. Chem. 1998

  • The Cockayne syndrome B protein, involved in transcription-coupled DNA repair, resides in an RNA polymerase II-containing complex. van Gool#, A.J., E. Citterio#, S. Rademakers, R. van Os, W. Vermeulen, A. Constantinou, J.M. Egly, D. Bootsma and J.H.J. Hoeijmakers. EMBO J. 1997 Oct 16:5955-5965.

Complete list of publications

Selected projects

  • In vivo RNAi screens for regulators of ubiquitin-mediated DNA damage response in mouse hematopoietic stem cells (HSCs)

  • (De)ubiquitinating enzymes networks in the regulation of DNA damage response pathways

  • Silencing of DNA damage signaling by USP3 deubiquitinating enzyme: molecular mechanism and role in tumor suppression

  • Maintenance of genome integrity by histone(de)ubiquitinating enzymes

Membership in scientific bodies/juries

  • Reviewer for: Nature Medicine, Nature Communications, Journal of Experimental Medicine, Nucleic Acid Research, Journal of Cell Science, The International Journal of Biochemistry & Cell Biology, Oncotarget, Experimental Hematology, Genome Biology and Evolution.

  • Reviewer: The French National Cancer Institute (INCa); Cancer Research UK


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  1. Cancer: Faulty DNA or Faulty DNA Repair Systems

    Cancer can occur when things go wrong in our genes, but also occur when the processes to fix damaged genes goes wrong. AcademiaNet members Dr. Elisabetta Citterio, Dr. Michela Di Virgilio (photo), Dr. Jacqueline Jacobs and Prof. Rocio Sotillo study the mechanisms of DNA repair.

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