Dr. Emily Flashman

• Emily Flashman studied Biochemistry with Pharmacology at the University of Southampton, followed by a D.Phil. in Biochemistry/Cardiovascular Medicine at the University of Oxford.

• After a few years as a postdoctoral researcher with Prof. Chris Schofield in the Department of Chemistry, she was awarded a Royal Society Dorothy Hodgkin Fellowship in 2010 and a L'Oreal For Women In Science Fellowship in 2011. During this period her work focussed on the molecular mechanisms of human oxygen-sensing enzymes.

• In 2015, Emily was awarded a BBSRC New Investigator grant to pursue the molecular characterisation of potential plant oxygen-sensing enzymes, and her research interests now focus on understanding how plants respond to reduced oxygen availability and developing mechanisms of enhancing flood tolerance in plants.

• Hammarlund EU, Flashman E, Mohlin S, Licausi F (2020). Oxygen-sensing mechanisms across eukaryotic kingdoms and their roles in complex multicellularity. Science. 370: eaba3512.

• White MD, Dalle Carbonare L, Lavilla Puerta M, Iacopino S, Edwards M, Dunne K, Pires E, Levy C, McDonough MA, Licausi F, Flashman E (2020). Structures of Arabidopsis thaliana oxygen-sensing plant cysteine oxidases 4 and 5 enable targeted manipulation of their activity. Proc Natl Acad Sci U S A. 117:23140-23147.

• Masson N, Keeley TP, Giuntoli B, White MD, Puerta ML, Perata P, Flashman E, Licausi F, Ratcliffe PJ (2019). Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants. Science. 365:65.

• Dalle Carbonare L, White M, Francini A, Shukla V, Perata P, Flashman E, Sebastiani L, Licausi F (2019). Zinc excess induces a hypoxia-like response by inhibiting cysteine oxidases in poplar roots. Plant Physiol. 180:1614.

  Gibbs DJ, Tedds HM, Labandera AM, Bailey M, White MD, Hartman S, Sprigg C, Mogg SL, Osborne R, Dambire C, Boeckx T, Paling Z, Voesenek LACJ, Flashman E, Holdsworth MJ (2018). Oxygen-dependent proteolysis regulates the stability of angiosperm polycomb repressive complex 2 subunit VERNALIZATION 2. Nat Commun. 9:5438. (31)

• White MD, Kamps JJAG, East S, Taylor Kearney LJ, Flashman E (2018). The Plant Cysteine Oxidases from Arabidopsis thaliana are kinetically tailored to act as oxygen sensors. J Biol Chem. 293: 11786-11795. (31)

• Hancock RL, Abboud MI, Smart TJ, Flashman E, Kawamura A, Schofield CJ, Hopkinson RJ (2018).Lysine-241 has a role in coupling 2OG turnover with substrate oxidation during KDM4-catalysed histone demethylation. Chembiochem. 19:917-921.

• Foskolou IP, Jorgensen C, Leszczynska KB, Olcina MM, Tarhonskaya H, Haisma B, D’Angiolella V, Myers WK, Domene C, Flashman E, Hammond EM (2017). Ribonucleotide reductase requires subunit switching in hypoxia to maintain DNA replication. Mol Cell. 66: 206-220.

• White MD, Klecker M, Hopkinson RJ, Weits DA, Mueller C, Naumann C, O’Neill R, Wickens J, Yang J, Brooks-Bartlett JC, Garman EF, Grossmann TN, Dissmeyer N, Flashman E (2017). Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets. Nat Commun. 8:14690.

• White MD and Flashman E (2016). Catalytic strategies of the non-heme iron dependent oxygenases and their roles in plant biology. Curr Opin Chem Biol.31: 126-135.

• Tarhonskaya H, Hardy AP, Howe EA, Loik ND, Kramer HB, McCullagh JS, Schofield CJ, Flashman E (2015). Kinetic investigations of the role of factor inhibiting hypoxia-inducible factor (FIH) as an oxygen sensor. J Biol Chem. 290: 19726-19742.

• Member of Editorial Board, Scientific Reports

• https://www.timeshighereducation.com/news/research/research-intelligence-breaking-through-the-glass-ceiling/417209.article

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