Dr. Ana Akrap
Physical sciencesExperimental condensed matter physics
Physical sciences, Environment
Crystallography, Structural chemistry, High-pressure science, Pharmaceutical sciences
Crystallisation and crystal growth of molecular crystals under non-ambient conditions (low temperature; high pressure)
X-ray diffraction under non-ambient conditions
Polymorphism, hydration and phase transitions of molecular crystals, with an emphasis on pharmaceuticals
Non-covalent interactions in molecular crystals (e.g. hydrogen bonding)
Dynamic processes in molecular crystals (e.g. disorder, thermal motion)
English, French, German, Italian
Saouane, S., Norman, S. E., Hardacre, C. and Fabbiani, F. P. A. (2013). Chem. Sci., 4 1270-1280. Pinning down the solid-state polymorphism of the ionic liquid [bmim][PF6].
Granero-García, R., Lahoz, F. J., Paulmann, C., Saoaune, S. and Fabbiani, F. P. A. (2012). CrystEngComm, 14, 8664-8670. A novel hydrate of alpha-cyclodextrin crystallised under high-pressure conditions.
Fabbiani, F. P. A., Buth, G., Dittrich, B. and Sowa, H. (2010). CrystEngComm,12, 2541-2550. Pressure-induced structural changes in wet vitamin B12.
Fabbiani, F. P. A., Levendis, D. C., Buth, G., Kuhs, W. F., Shankland, N. and Sowa, H. (2010). CrystEngComm, 12, 2354-2360. Searching for novel crystal forms by in situ high-pressure crystallisation: the example of gabapentin heptahydrate.
Fabbiani, F. P. A., Dittrich, B., Florence, A. J., Gelbrich, T., Hursthouse, M. B., Kuhs, W. F., Shankland, N. and Sowa, H. (2009). CrystEngComm, 11, 1396-1406. Crystal structures with a challenge: high-pressure crystallisation of ciprofloxacin sodium salts and their recovery to ambient pressure.
Fabbiani, F. P. A., Byrne, L. T., McKinnon, J. J., and Spackman, M. A. (2007). CrystEngComm, 9(9), 728-731: Solvent inclusion in the structural voids of form II carbamazepine: single-crystal X-ray diffraction, NMR spectroscopy and Hirshfeld surface analysis.
Fabbiani, F. P. A., Allan, D. R., David, W. I. F., Davidson, A. J., Lennie, A. R., Parsons, S., Pulham, C. R. and Warren, J. E. (2007). Cryst. Growth Des., 7(4), 1115-1124: High-pressure studies of pharmaceutical – an exploration of the behavior of piracetam.
Fabbiani, F. P. A. and Pulham, C. R. (2006). Chem. Soc. Rev., 35, 932-342: High-pressure studies of pharmaceutical compounds and energetic materials.
DFG-Emmy Noether Junior Research Group: "High-pressure methodologies to discover novel physical forms and promote structural variation amongst biological and pharmaceutical materials"
This project focusses on studying the effects of high pressure, usually up to 2 GPa (~20000 atmospheres) on the crystal structure and crystallisation behaviour of materials of biological and pharmaceutical interest. The principal aims here are: a) enable a thorough exploration of the crystallisation space of an active pharmaceutical ingredient; b) quantify and understand the importance of molecular flexibility and dynamics in promoting hydration and conformational changes in small biomolecules.
Royal Society of Chemistry
Deutsche Gesellschaft für Kristallographie
British Crystallographic Association
Reviewing funding applications for Dorothea Schlözer Stipends from the Georg-August-Universität Göttingen, DE, 2013
Member of Institut Laue-Langevin (ILL) Review Subcommittee 5A (Crystallography), FR, 2012 – 2014
Member of Oak Ridge National Laboratory (ORNL) Neutron Scattering Science Review Committee, US, since 2010
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Physical sciencesExperimental condensed matter physics
Physical sciencesPreparative and physical chemistry of polymersNanotechnology
Biological and related sciences , Physical sciencesBioelectrochemistry, Synthetic Biology, Chemical Biology
Environment, Mathematics and statisticsbiogeochemistry, isotope geochemistry, soil science