Dr. Malin Ah-King
Biological and related sciences , Evolutionary biology, Animal behaviour, Gender studies, Science studies
Biological and related sciences , Physical sciences
Peptide chemistry, protein chemistry, biochemistry, molecular biology, expanded genetic code
My group investigates topologies of protein-protein interactions in the live cell by combining chemical tools and modern molecular biology techniques. We use the expanded genetic code technology to incorporate crosslinking amino acids into proteins at specific sites, and we map systematically interactions surfaces to discover regions of proximity of associated partners. We are currently focused on unveiling the binding mode of natural peptide hormones to class B GPCRs and investigating the topology of interactions involved in GPCR-associated protein complexes.
Emmy-Noether Grant of the German Research Foundation to establish an independent research group, 2013
Research fellowship by the European Commission, FP7 Marie Curie Actions, 2010
"Nachwuchswissenschaftlerin-Preis" (Young Scientist Award) by the Forschungsverbund Berlin e.V., 2009
Friedrich-Weygand-Award by the Max-Bergmann-Kreis, 2009
Research fellowship by the German Research Foundation (DFG), 2009
Research Fellowship by Fondazione Aldo Gini, Italy, 2004
English, German, Italian, Spanish
Coin I, Katritch V, Sun T, Xiang Z, Siu FY, Beyermann M, Stevens RC, Wang L, Genetically encoded chemical probes reveal the binding path of Urocortin-I to CRF Class B GPCR, Cell, 155, 1258-69 (2013).
Xiang Z, Ren H, Hu YS, Coin I, Wei J, Cang H, Wang L, Adding an unnatural covalent bond to proteins through proximity-enhanced bioreactivity. Nat. Methods 10, 885-8 (2013).
Coin I, Perrin MH, Vale WW, Wang L, Photocrosslinkers incorporated into G-Protein-Coupled-Receptors in mammalian cells: a ligand comparison, Angew. Chem. Int. Ed. Engl. 50, 8077-8081 (2011).
Coin I, Beyermann M, Bienert M, Solid-phase peptide synthesis: from standard procedures to the synthesis of difficult sequences. Nat. Protocols 2, 3247-3256 (2007).
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Biological and related sciences , Evolutionary biology, Animal behaviour, Gender studies, Science studies
Biological and related sciences , Physical sciences, Environmental virology, Molecular and structural biology, biochemistry
Biological and related sciences , Evolutionary biology, Evolutionary genetics
Biological and related sciences , Environment, Plant Ecology, Conservation Biology, Landscape Genomics