Prof. Dr. Amparo Acker-Palmer
Biological and related sciences, Health, Cell Biology, Cellular and Molecular Neuroscience, Vascular Biology, Tumour Biology
Dr. Irene Coin
Nominated by
- German Research Foundation (DFG)
- AcademiaNet member since 24.02.2015
- AcademiaNet- Selection Criteria
Academic Discipline/Fields
- Natural sciences, mathematics and statistics
Field
Biological and related sciences, Physical sciences
Area of specialisation
Peptide chemistry, protein chemistry, biochemistry, molecular biology, expanded genetic code
Research interests
My group investigates topologies of protein-protein interactions in the live cell by combining chemical tools and modern molecular biology techniques. We use the expanded genetic code technology to incorporate crosslinking amino acids into proteins at specific sites, and we map systematically interactions surfaces to discover regions of proximity of associated partners. We are currently focused on unveiling the binding mode of natural peptide hormones to class B GPCRs and investigating the topology of interactions involved in GPCR-associated protein complexes.
Distinctions and Awards
Emmy-Noether Grant of the German Research Foundation to establish an independent research group, 2013
Research fellowship by the European Commission, FP7 Marie Curie Actions, 2010
"Nachwuchswissenschaftlerin-Preis" (Young Scientist Award) by the Forschungsverbund Berlin e.V., 2009
Friedrich-Weygand-Award by the Max-Bergmann-Kreis, 2009
Research fellowship by the German Research Foundation (DFG), 2009
Research Fellowship by Fondazione Aldo Gini, Italy, 2004
Interested in
- Professorship
Languages
English, German, Italian, Spanish
Doctorate
- 2008: Peptide chemistry
Short CV/Education and training
- 2003Master in Chemistry, University of Padua, IT
- 2004 – 2008PhD work, FMP Berlin, DE
- 2008Dr. Rer. Nat., Chemistry, Universtität Leipzig, DE
- 2008 – 2009Research assistant, The Biodesign Institute at ASU, Tempe, AZ
- 2009 – 2011DFG fellow, The Salk Institute, La Jolla, CA
- 2011 – 2013Marie Curie fellow, The Salk Institute, La Jolla, CA
- 2013 – 2014Marie Curie Fellow, MDC Berlin, DE
- Since 2014Emmy Noether group leader
Selected publications
Coin I, Katritch V, Sun T, Xiang Z, Siu FY, Beyermann M, Stevens RC, Wang L, Genetically encoded chemical probes reveal the binding path of Urocortin-I to CRF Class B GPCR, Cell, 155, 1258-69 (2013).
Xiang Z, Ren H, Hu YS, Coin I, Wei J, Cang H, Wang L, Adding an unnatural covalent bond to proteins through proximity-enhanced bioreactivity. Nat. Methods 10, 885-8 (2013).
Coin I, Perrin MH, Vale WW, Wang L, Photocrosslinkers incorporated into G-Protein-Coupled-Receptors in mammalian cells: a ligand comparison, Angew. Chem. Int. Ed. Engl. 50, 8077-8081 (2011).
Coin I, Beyermann M, Bienert M, Solid-phase peptide synthesis: from standard procedures to the synthesis of difficult sequences. Nat. Protocols 2, 3247-3256 (2007).
Complete list of publications
Testimonials
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