Dr. Irene Coin,
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Dr. Irene Coin

Nominated by

  • German Research Foundation (DFG)
  • AcademiaNet member since 24.02.2015
  • AcademiaNet- Selection Criteria


Academic Discipline/Fields

  • Natural sciences, mathematics and statistics


Field

Biological and related sciences , Physical sciences



Area of specialisation

Peptide chemistry, protein chemistry, biochemistry, molecular biology, expanded genetic code



Research interests

  • My group investigates topologies of protein-protein interactions in the live cell by combining chemical tools and modern molecular biology techniques. We use the expanded genetic code technology to incorporate crosslinking amino acids into proteins at specific sites, and we map systematically interactions surfaces to discover regions of proximity of associated partners. We are currently focused on unveiling the binding mode of natural peptide hormones to class B GPCRs and investigating the topology of interactions involved in GPCR-associated protein complexes.



Distinctions and Awards

  • Emmy-Noether Grant of the German Research Foundation to establish an independent research group, 2013

  • Research fellowship by the European Commission, FP7 Marie Curie Actions, 2010

  • "Nachwuchswissenschaftlerin-Preis" (Young Scientist Award) by the Forschungsverbund Berlin e.V., 2009

  • Friedrich-Weygand-Award by the Max-Bergmann-Kreis, 2009

  • Research fellowship by the German Research Foundation (DFG), 2009

  • Research Fellowship by Fondazione Aldo Gini, Italy, 2004



Interested in

  • Professorship


Languages

English, German, Italian, Spanish



Doctorate

  • 2008: Peptide chemistry




Short CV/Education and training

  • 2003
    Master in Chemistry, University of Padua, IT

  • 2004 – 2008
    PhD work, FMP Berlin, DE

  • 2008
    Dr. Rer. Nat., Chemistry, Universtität Leipzig, DE

  • 2008 – 2009
    Research assistant, The Biodesign Institute at ASU, Tempe, AZ

  • 2009 – 2011
    DFG fellow, The Salk Institute, La Jolla, CA

  • 2011 – 2013
    Marie Curie fellow, The Salk Institute, La Jolla, CA

  • 2013 – 2014
    Marie Curie Fellow, MDC Berlin, DE

  • Since 2014
    Emmy Noether group leader

Selected publications

  • Coin I, Katritch V, Sun T, Xiang Z, Siu FY, Beyermann M, Stevens RC, Wang L, Genetically encoded chemical probes reveal the binding path of Urocortin-I to CRF Class B GPCR, Cell, 155, 1258-69 (2013).

  • Xiang Z, Ren H, Hu YS, Coin I, Wei J, Cang H, Wang L, Adding an unnatural covalent bond to proteins through proximity-enhanced bioreactivity. Nat. Methods 10, 885-8 (2013).

  • Coin I, Perrin MH, Vale WW, Wang L, Photocrosslinkers incorporated into G-Protein-Coupled-Receptors in mammalian cells: a ligand comparison, Angew. Chem. Int. Ed. Engl. 50, 8077-8081 (2011).

  • Coin I, Beyermann M, Bienert M, Solid-phase peptide synthesis: from standard procedures to the synthesis of difficult sequences. Nat. Protocols 2, 3247-3256 (2007).



Complete list of publications

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