Short CV/Education and training

  • 1973
    Born in Winterswijk, The Netherlands

  • 1991
    Graduated from High School (Voortgezet Wetenschappelijk Onderwijs): Katholieke Scholengemeenschap Marianum, Groenlo, The Netherlands

  • 1991 – 1996
    University of Nijmegen, The Netherlands: studied Biology, with specialization in Medical Biology

  • 1992
    Propedeuse Biology, equivalent Bachelor's (BSc) Degree from University of Nijmegen

  • 1996
    Masters (MSc) Degree in Biology (cum laude), specialization Medical Biology from University of Nijmegen

  • 1996 – 2000
    PhD study at the Netherlands Cancer Institute, Division of Molecular Carcinogenesis, Amsterdam, The Netherlands

  • 2000
    PhD degree (cum laude) from University of Utrecht, The Netherlands (promoter: Prof. Dr. Rene Bernards, co-promoter: Dr. M. van Lohuizen)

  • 2000 – 2001
    Postdoc at the Netherlands Cancer Institute, Divisions of Molecular Carcinogenesis and Molecular Genetics, Amsterdam the Netherlands

  • 2002 – 2004
    Postdoctoral Fellow for the Dutch Cancer Society at the Rockefeller University in New York, USA

  • 2004
    Postdoctoral Fellow for the Dutch Cancer Society at the Netherlands Cancer Institute, Division of Molecular Genetics, Amsterdam, The Netherlands

  • 2005 – 2006
    Senior Postdoc at the Netherlands Cancer Institute, Division of Molecular Genetics, Amsterdam, The Netherlands

  • 2006 – 2008
    Research associate/ Project leader at the Netherlands Cancer Institute, Division of Molecular Genetics, Amsterdam, The Netherlands

  • 2008 – 2012
    Junior Group Leader (assistant professor level, tenure-track) at the Netherlands Cancer Institute, Division of Molecular Genetics and Division of Molecular Oncology, Amsterdam, The Netherlands

  • Since 2012
    Group Leader (associate professor level, tenured) at the Netherlands Cancer Institute, Division of Molecular Oncology, Amsterdam, The Netherlands

Selected publications

  • de Krijger I, van der Torre J, Peuscher MH, Eder M, Jacobs JJL. H3K36 dimethylation by MMSET promotes classical non-homologous end-joining at unprotected telomeres. Oncogene 39:4814-4827 (2020)

  • Dev H, Chiang TW, Lescale C, de Krijger I, Martin AG, Pilger D, Coates J, Sczaniecka-Clift M, Wenming Wei, Ostermaier M, Herzog M, Lam J, Shea A, Demir M, Wu Q, Yang F, Fu B, Lai Z, Balmus G, Belotserkovskaya R, Serra V, O’Connor MJ, Bruna A, Beli P, Pellegrini L, Caldas C, Deriano L*, Jacobs JJL*, Galanty Y* and Jackson SP*. Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells. Nature Cell Biol. 20, 954–965 (2018)

    *co-corresponding authors

  • Simonetta M, de Krijger I, Serrat J, Moatti N, Fortunato D, Hoekman L, Bleijerveld OB, Altelaar AFM, Jacobs JJL. H4K20me2 distinguishes pre-replicative from post-replicative chromatin to appropriately direct DNA repair pathway choice by 53BP1-RIF1-MAD2L2. Cell Cycle 17:1, 124-136 (2018)

  • Boersma V, Moatti N, Segura-Bayona S, Peuscher MH, van der Torre J, Wevers BA, Orthwein A, Durocher D and Jacobs JJL. MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end-resection. Nature 521, 537-540 (2015).

  • Jacobs, J.J.L. Loss of telomere protection: consequences and opportunities. Frontiers in Oncology 3, 88 (2013).

  • Jacobs, J.J.L. Senescence: back to telomeres. Nat Rev Mol Cell Biol. 4, 196 (2013).

  • Peuscher, M.H and Jacobs, J.J.L. Posttranslational control of telomere maintenance and the telomere damage response. Cell Cycle 11, 1524-1534 (2012).

  • Jacobs, J.J.L. Fusing telomeres with RNF8. Nucleus 3, 2 (2012).

  • Peuscher, M.H and Jacobs, J.J.L. DNA-damage response and repair activities at uncapped telomeres depend on RNF8. Nature Cell Biol. 13, 1139-1145 (2011).

  • Jacobs, J.J.L, and de Lange, T. p16INK4a as a Second Effector of the Telomere

    Damage Pathway. Cell Cycle 4, 1364-1368 (2005).

  • Jacobs, J.J.L. and de Lange, T. Significant role for p16INK4a in p53-independent telomere-directed senescence. Current Biol. 14: 2302-2308 (2004).

  • Jacobs, J.J.L., Keblusek, K., Robanus-Maandag, E., Kristel, P., Lingbeek, M., Nederlof, P.M., van Welsem, T., van de Vijver, M.J., Koh, E.Y., Daley, G.Q., van Lohuizen, M. Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19ARF) and is amplified in a subset of human breast cancers. Nature Genetics 26: 291-299 (2000).

  • Jacobs, J.J.L., Scheijen B., Voncken, J.W., Kieboom, K., Berns, A., van Lohuizen, M. Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc induced apoptosis via INK4a/ARF. Genes & Development 13: 2678-2690 (1999).

  • Jacobs, J.J.L., Kieboom, K., Marino, S., DePinho, R.A., van Lohuizen, M. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 397: 164-168 (1999).

Complete list of publications

Membership in scientific bodies/juries

  • Since 2020 member Dutch Cancer Society Advisory Board

  • Since 2019 member NKI Diversity and Inclusion Committee

  • Since 2017 Advisory Editorial Board Member of Life Science Alliance (alliance of EMBO, Rockefeller University and Cold Spring Harbor Laboratory Press)

  • 2014-2016 member referee panel Norwegian Research Council.

  • Since 2013 member Studygroup Nucleic Acids of the Chemical Sciences Division of NWO

  • Since 2013 member NKI seminar committee

  • Selected in 2012 as member of the EMBO Young Investigators Program

  • Member VVViO: Association for Innovational Research Incentives

  • Since 2006 member of review and selection committees for the Netherlands Organization for Scientific Research (NWO)

Soft Skills/Other activities and achievements

Other activities and achievements/family

  • 3 children

  • 2013-2017 Chair and member of the MR (representative advisory board) of primary School 'de Mijlpaal', Amsterdam


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