Prof. Dr. Anna Akhmanova
Biological and related sciences, Cell Biology, Molecular Biology, Biochemistry, Microscopy
Biological and related sciences, Education, Health
Platelet biology
Providing mechanistic insight into the process of thrombus formation
Characterising the vascular-directed effects of platelet-thrombi
Effectively curtailing platelet activities in order to find new reference points for antithrombotic medication
Dutch, English
Mattheij NJA, Swieringa F, Berny-Lang MA, May F, van der Meijden PEJ, Suylen DPL, Nolte MW, Hackeng T, McCarty OJT, Heemskerk JWM, Cosemans JMEM. Coated platelets function in platelet-dependent fibrin formation via integrin αIIbβ3 and transglutaminase factor XIII. Haematologica. 2016;101(4):427-36. IF 5.81
McCarty OJT, Ku D, Sugimoto M, King MR, Cosemans JMEM, Neeves KB. Dimensional analysis and scaling relevant to flow models of thrombus formation. J Thromb Haemost. 2016:14(3):619-22. IF 5.72
Heemskerk JWM, Cosemans JMEM, van der Meijden PEJ. Platelets and coagulation. Platelets in thrombotic and non-thrombotic disorders – Pathophysiology, pharmacology and therapeutics. Springer International Publishing. Editors: Gresele, P., Kleiman, N.S., Lopez, J.A., Page, C.P. ISBN 978-3-319-47462-5.
Mastenbroek TG, Feijge MAH, Kremers RK, van den Bosch M, Swieringa F, De Groef L, Moons L, Bennett C, Gheveart C, Johnson JL, van der Meijden PEJ, Cosemans JMEM. Platelet-associated matrix metalloproteinases regulate thrombus formation and exert local collagenolytic activity. Arterioscler Thromb Vasc Biol. 2015;35:2554-61. IF 6.00
Agbani EO, Brown E, van den Bosch MTJ, Williams CM, Mattheij NJA, Cosemans JMEM, Collins PW, Heemskerk JWM, Hers I, Poole AW. Coordinated membrane ballooning and procoagulant-spreading in human platelets. Circ. 2015;132:1414-24. IF 14.43
Editorial (doi:10.1161/CIRCULATIONAHA.115.018833) dedicated to this paper.
Mastenbroek TG, van Geffen JP, Heemskerk JWM, Cosemans JMEM. Acute and persistent platelet and coagulant activities in atherothrombosis. J Thromb Haemost. 2015;13 Suppl 1:S272-80. IF 5.72
de Witt SM, Swieringa F, Cavill R, Lamers MME, van Kruchten R, Mastenbroek TG, Baaten C, Coort S, Pugh N, Schulz A, Scharrer I, Jurk K, Zieger B, Clemetson KJ, Farndale RW, Heemskerk JWM, Cosemans JMEM. Identification of platelet function defects by multi-parameter assessment of thrombus formation. Nat Commun. 2014;5:4257.
Beinsberger J, Heemskerk JWM, Cosemans JMEM. Chronic arthritis and cardiovascular disease: altered blood parameters give rise to a prothrombotic propensity. Semin Arthritis Rheum. 2014;44(3):345-52. IF 3.93.
Kuijpers MJE, van der Meijden PEJ, Feijge MAH, Mattheij NJ, May F, Govers-Riemslag J, Meijers JC, Heemskerk JWM, Renné T, Cosemans JMEM. Factor XII regulates the pathological process of thrombus formation on ruptured plaques. Arterioscler Thromb Vasc Biol. 2014;34(8):1674-80. IF 6.00
Heemskerk JWM, Mattheij NJA, Cosemans JMEM. Platelet-based coagulation: different populations, different functions. J Thromb Haemost. 2013;11(1):2-16. IF 5.72
Cosemans JMEM, Schols SEM, Stefanini L, Feijge MAH, Hamulyak K, Deckmyn H, Bergmeier W, Heemskerk JWM. Key role of glycoprotein Ib-V-IX and von Willebrand factor in platelet-dependent fibrin fiber formation at low shear flow. Blood 2011;117(2):651-660. IF 10.45
Targeting the release of platelet proteins in the prevention of recurrent cardiovascular events – funded by the Netherlands Organisation for Scientific Research
Silencing the platelet thrombus to avert pathological vascular remodeling – funded by the Dutch Heart Foundation
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Biological and related sciences, Cell Biology, Molecular Biology, Biochemistry, Microscopy
Biological and related sciences, Physical sciences, Environmental virology, Molecular and structural biology, biochemistry
Health, Public Health
Health, Academic Medicine