Short CV/Education and training

  • Since 2016
    Group leader, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Sweden

  • 2010 – 2018
    Group leader, Genome-Scale Biology Research Program, University of Helsinki, Finland

  • 2009
    Docent in Cell and Molecular Biology, University of Helsinki, Finland

  • 2005 – 2009
    Post-doctoral researcher, Molecular Cancer Biology Program, University of Helsinki, Finland

  • 2002 – 2004
    Post-doctoral fellow, Life Sciences Institute, Internal Medicine, University of Michigan, USA

  • 2002
    PhD in Biochemistry & Cancer biology, University of Helsinki, Finland

  • 1995
    MSc in Biochemistry, University of Helsinki, Finland

Selected publications

  • 1. Gucciardo E, Loukovaara S, Korhonen A, Repo P, Martins B, Vihinen H, Jokitalo E and LEHTI K. Microenvironment of proliferative diabetic retinopathy support lymphatic neovascularization. Journal of Pathology, 245(2):172-185, 2018.

  • 2. Pekkonen P, Alve SE, Balistreri G, Gramolelli S, Tatti-Bugaeva O, Paatero I, Niiranen O, Ojala K, Perälä N, Taiwo A, Zinovkina N, Repo P, Icay K, Ivaska J, Saharinen P, Hautaniemi S, LEHTI K and Ojala PM. Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation. eLife, May 1;7. pii: e32490, 2018.

  • 3. Turunen SP, Tatti-Bugaeva O and LEHTI K. Membrane-type matrix metalloproteases as diverse effectors of cancer progression. Biochimica et Biophysica Acta -Molecular Cell Research 1864:1974-1988, 2017.

  • 4. Tatti O, Gucciardo E, Pekkonen P, Holopainen T, Louhimo R, Repo P, Lohi J, Maliniemi P, Rantanen V, Hautaniemi S, Alitalo K, Ranki A, Ojala P, Keski-Oja J and LEHTI K. MMP16-dependent proteolytic switch controls melanoma morphology and lymphatic invasion. Cancer Research 75(10):2083-94, 2015.

  • 5. von Nandelstadh P, Gucciardo E, Lohi J, Li R, Sugiyama N, Carpén O and LEHTI K. Actin-associated protein palladin promotes tumor cell invasion by linking extracellular matrix degradation to cell cytoskeleton. Molecular Biology of the Cell 25:2556-70, 2014.

  • 6. Sugiyama N, Gucciardo E, Tatti O, Varjosalo M, Hyytiäinen M, Gstaiger M and LEHTI K. EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion. Journal of Cell Biology 201: 467-84, 2013.

  • 7. Cheng F, Pekkonen P, Laurinavicius S, Sugiyama N, Henderson S, Günther T, Rantanen V, Kaivanto E, Aavikko M, Sarek G, Hautaniemi S, Biberfeld P, Aaltonen L, Grundhoff A, Boshoff C, Alitalo K, LEHTI K*, and Ojala PM*. KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition. Cell Host & Microbe. 10(6): 577-590, 2011. (*equal contribution)

  • 8. Sugiyama N, Varjosalo M, Meller P, Lohi J, Chan KM, Zhou Z, Alitalo K, Taipale J, Keski-Oja J and LEHTI K. FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane-type-1 matrix metalloproteinase-FGFR4 complex. Proceedings of the National Academy of the Sciences USA 107: 15786-91, 2010.

  • 9. Sugiyama N, Varjosalo M, Meller P, Lohi J, Hyytiäinen M, Kilpinen S, Kallioniemi O, Ingvarsen S, Engelholm LH, Taipale J, Alitalo K, Keski-Oja J and LEHTI K. Fibroblast growth factor receptor-4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation. Cancer Research 70: 7851-61, 2010.

  • 10. LEHTI K, Allen E, Holmbeck K, Birkedal-Hansen H, Miyake Y, Chun T, and Weiss SJ. MT1-MMP-PDGF receptor-β axis regulates mural cell investment of the microvasculature. Genes & Development. 19: 979-991, 2005.


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