Short CV/Education and training

  • 1996 – 2001
    Studies in Chemistry, Christian Albrechts University, Kiel, Germany

  • 2001
    Diploma in Chemistry

  • 2002 – 2005
    Dr. rer. nat. in Organic Chemistry, summa cum laude, Max-Planck-Institute of Molecular Physiology, Dortmund, and University Dortmund, Germany

  • 2005 – 2007
    Postdoctoral stay at Harvard University

  • Since 2007
    Group leader at the European Molecular Biology Laboratory

Selected publications

  • K. Pavic, P. Rios, K. Dzeyk, C. Koehler, E. A. Lemke, M. Köhn. Unnatural amino acid mutagenesis reveals dimerization as a negative regulatory mechanism of VHR's phosphatase activity. ACS Chem. Biol. 2014, 9, 1451-1459.

  • C. Meyer, K. Temmerman, M. Tatarek-Nossol, B. Hoeger, V. Pogenberg, J. Bernhagen, M. Wilmanns, A. Kapurniotu, M. Köhn. Development of accessible peptidic tool compounds to study the phosphatase PTP1B in intact cells. ACS Chem. Biol. 2014, 9, 769-776. Highlighted as journal cover.

  • G. Reither, J. Chatterjee, M. Beullens, M. Bollen, C. Schultz, M. Köhn. Chemical activators of protein phosphatase-1 induce calcium release inside intact cells. Chem. Biol. 2013, 20, 1179?1186.

  • J. Chatterjee, M. Köhn. Targeting the untargetable: Recent advances in the selective chemical modulation of protein phosphatase-1 activity. Curr. Opin. Chem Biol. 2013, 17, 361-368.

  • X. Li, M. Wilmanns, J. Thornton, M. Köhn. Elucidating human phosphatase-substrate networks. Sci. Signal. 2013, 6, rs10.

  • P. Rios, X. Li, M. Köhn. Molecular mechanisms of the PRL phosphatases. FEBS J. 2013, 280, 505-524.

  • J. Chatterjee, M. Beullens, R. Sukackaite, J. Qian, B. Lesage, D. Hart, M. Bollen, M. Köhn. Development of a peptide that selectively activates protein phosphatase-1 in living cells. Angew. Chem. Int. Ed. 2012, 51, 10054-10059.

  • M. Bru, S. P. Kotkar, N. Kar, M. Köhn. Development of a solid phase synthesis strategy for soluble phosphoinositide analogues. Chem. Sci. 2012, 3, 1893-1902.

  • V. McParland, G. Varsano, X. Li, J. Thornton, J. Baby, A. Aravind, C. Meyer, K. Pavic, P. Rios, M. Köhn. The metastasis-promoting phosphatase PRL-3 shows activity toward phosphoinositides. Biochemistry 2011, 50, 7579-7590.

Complete list of publications

Selected projects

  • Polynucleotide inhibitors of HCV (postdoc stay)


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