Dr. Sonja-Verena Albers
Biological and related sciences, Molecular biology, molecular microbiology, biochemistry, membrane protein biochemistry
Biological and related sciences
Signal Transduction
Chromatin and Transcription
Signal Transduction
Molecular Medicine
Elected as Fellow of the Academy of Medical Sciences, 2006
Elected as Fellow of the Royal Society, 2003
Friedrich Miescher Prize of the Swiss Biochemical Society, 1990
Elected as EMBO Member, 1989
Swiss National Science Foundation Advanced Fellowship, 1984 – 1986
EMBO Long-Term Fellowship, 1981 – 1984
English, German
Mieszczanek J, de la Roche M & Bienz M (2008) A role of Pygopus as an anti-repressor in facilitating Wnt-dependent transcription. Proc Natl Acad Sci USA 105, 19324-19329.
Metcalfe C, Mendoza-Topaz C, Mieszczanek J & Bienz M (2010) Stability elements in the LRP6 cytoplasmic tail confer efficient signaling upon DIX-dependent polymerisation. J Cell Sci 123, 1588-1599.
Metcalfe C, Ibrahim AEK, Graeb M, de la Roche M, Schwarz-Romond T, Fiedler M, Winton DJ, Corfield A & Bienz M (2010) Dvl2 promotes intestinal length and neoplasia in the ApcMin mouse model for colorectal cancer. Cancer Res 70, 6629-6638.
Miller TCR, Rutherford TJ, Johnson CM, Fiedler M & Bienz M (2010) Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor. J Mol Biol 401, 969-984.
Fiedler M, Mendoza-Topaz C, Rutherford TJ, Mieszczanek J & Bienz M (2011) Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating beta-catenin. Proc Natl Acad Sci USA 108, 1937-1942.
Metcalfe C & Bienz M (2011) Inhibition of GSK3 by Wnt signaling – two contrasting models. J Cell Sci 124, 3537-3544.
Mendoza-Topaz C, Mieszczanek J & Bienz M (2011) The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin’s interaction with Dishevelled. Open Biol 1, 110013.
Licchesi JDF, Mieszczanek J, Mevissen TE, Rutherford TJ, Akutsu M, Virdee S, Oualid FE, Chin JW, Ovaa H, Bienz M & Komander D (2011) An Ankyrin-repeat ubiquitin-binding domain determines TRABID’s specificity for atypical ubiquitin chains. Nature Struct Mol Biol 19, 62-71.
de la Roche M, Rutherford TJ, Gupta D, Veprintsev DB, Saxty B, Freund SM & Bienz M (2012) An intrinsically labile alpha-helix abutting the BCL9-binding site of beta-catenin is required for its inhibition by carnosic acid. Nature Commun 3, 680.
Miller TCR, Mieszczanek J, Sánchez-Barrena MJ, Rutherford TJ, Fiedler M & Bienz M (2013) Evolutionary adaptation of the fly Pygo PHD finger towards recognizing histone H3 tail methylated at arginine 2. Structure 21, 2208-2220.
de la Roche M, Ibrahim AEK, Mieszczanek J & Bienz M (2014) LEF1 and B9L shield beta-catenin from inactivation by Axin, desensitizing colorectal cancer cells to tankyrase inhibitors. Cancer Res, in press.
Elected to EMBO Council (1994; served on Council 1995 – 2000)
Chair of EMBO Membership and Publications Committee (1996 – 2001)
MRC Advisory Board (1997 – 1999)
MRC Molecular and Medicine Board (1999 – 2003)
MRC Cross Board (2002 – 2004)
Elected to the Council of the Royal Society (2004; served on Council 2004 – 2006)
Chair of Royal Society Partnership Grants Committee (2007 – 2010)
CR-UK Clinical Fellowship Selection Panel (2010 – 2012)
Royal Society Summer Science Exhibition Committee (2011 – 2013)
European Research Council Starting Grant Panel LS3 (since 2012)
Royal Society Dorothy Hodgkin Fellowship Panel (since 2014)
Chair of Ethical Review Committee of Animal Research at LMB (2000 – 2003)
Director of Studies at LMB (2003 – 2006)
Adjunct Faculty Member, Cancer Research UK Cambridge Research Institute (since 2011)
EMBO Journal (1991 – 1993; 1995 – 1997; 1999 – 2004)
Mechanisms of Development (1990 – 2010)
Development (1998 – 2003)
EMBO Reports (2000 – 2004)
Genes & Development (since 2001)
Trends in Biochemical Sciences (since 2001)
Molecular Cancer (since 2010)
Faculty of 1000 Biology (since 2001)
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Biological and related sciences, Molecular biology, molecular microbiology, biochemistry, membrane protein biochemistry
Biological and related sciences, Health, Cell Biology, Cellular and Molecular Neuroscience, Vascular Biology, Tumour Biology
Biological and related sciences, Physical sciences, Bioelectrochemistry, Synthetic Biology, Chemical Biology
Biological and related sciences, Environment, Plant Ecology, Conservation Biology, Landscape Genomics
Mariann Bienz investigates the mechanisms behind the signalling pathways that switch on gene transcription and how their dysfunction can ultimately cause cancer.