Dr. Irene Agyepong
Health, Public Health
Health, Physical sciences
Protein chemistry, proteomics, mass spectrometry
Mass Spectrometry, Lipidomics, Proteomics
Chartered Chemist
English
LYNCH A, TAMMIREDDY SR, DOHERTY MK, WHITFIELD PD, CLARKE DJ (2019):The glycine lipids of Bacteroides thetaiotaomicron are important for fitness during growth in vivo and in vitro. Applied Environmental Microbiology, in press
GEARY B, MAGEE K, CASH P, HUSI H, YOUNG IS, WHITFIELD PD, DOHERTY MK* (2019): Acute stress alters the rates of degradation of cardiac muscle proteins, Journal of Proteomics, 191, 124-130
DORGAU B, FELEMBAN M, HILGEN G, KIENING M, ZERTI D, HUNT NC, DOHERTY M, WHITFIELD P, HALLAM D, WHITE K, DING Y, KRASNOGOR N, AL-AAMA J, ASFOUR HZ, SERNAGOR E, LAKO M (2019), Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of human pluripotent stem cell derived retinal organoids, 199, 63-75
BOYAPATI RK, DORWARD DA, TAMBORSKA A, KALLA R, VENTHAM NT, DOHERTY MK, WHITFIELD PD, GRAY M, LOANE J, ROSSI AG, SATSANGI J, HO GT (2018): Mitochondrial DNA is a pro-inflammatory damage-associated molecular pattern (DAMP) released during active IBD, Inflammatory Bowel Diseases, 24, 2113-2122
JEROMSON S, MACKENZIE I, DOHERTY MK, WHITFIELD PD, BELL G, DICK J, SHAW A, RAO F, ASHCROFT S, PHILP A, GALLOWAY S, GALLAGHER I, AND HAMILTON DL. (2018): Lipid remodelling and an altered membrane proteome may drive the effects of EPA and DHA treatment on skeletal muscle glucose uptake and protein accretion, American Journal of Physiology-Endocrinology and Metabolism, 314, E605-E619
TORATI LS, MIGAUD H, DOHERTY MK, SIWY J, MULLEN W, MESQUITA PEC, ALBALAT A. (2017): Comparative proteome and peptidome analysis of the cephalic fluid secreted by Arapaima gigas (Teleostei: Osteoglossidae) during and outside parental care. PLoS One. 12, e0186692
DORWARD DA, LUCAS CD, DOHERTY MK, CHAPMAN GB, SCHOLEFIELD EJ, CONWAY MORRIS A, FELTON JM, KIPARI T, HUMPHRIES DC, ROBB CT, SIMPSON AJ, WHITFIELD PD, HASLETT C, DHALIWAL K, ROSSI AG. (2017): Novel role for endogenous mitochondrial formylated peptide-driven formyl peptide receptor 1 signalling in acute respiratory distress syndrome, Thorax, 72, 928-936.
EDMONDS MJ, GEARY B, DOHERTY MK, MORGAN A. (2017): Analysis of the brain palmitoyl-proteome using both acyl-biotin exchange and acyl-resin-assisted capture methods. Scientific Reports, 7, 3299.
MORRICE N, MCILROY GD, TAMMIREDDY SR, REEKIE J, SHEARER KD, DOHERTY MK, DELIBEGOVIĆ M, WHITFIELD PD, MODY N. (2017): Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice, Scientific Reports, 7, 43782.
MAGALHAES J, GEGG ME, MIGDALSKA A, DOHERTY MK, WHITFIELD PD, SCHAPIRA AHV. (2016): Autophagic lysosome reformation dysfunction in glucocerebrosidase deficient cells: relevance to Parkinson Disease. Human Molecular Genetics, 25, 3432-3445.
PLUCINSKA K, DEKERYTE R, KOSS D, SHEARER K, MODY N, WHITFIELD PD, DOHERTY MK, MINGARELLI M, WELCH A, RIEDEL G, DELIBEGOVIC M, PLATT B. (2016): Neuronal human BACE1 knock-in induces systemic diabetes in mice, Diabetologia, 59,1513-1523.
GEARY B, MAGEE K, CASH P, YOUNG IS, WHITFIELD PD, DOHERTY MK. (2016): Determining synthesis rates of individual proteins in zebrafish (Danio rerio) with low levels of a stable isotope labelled amino acid, Proteomics, 16, 1398-1406.
CATTANEO D, WARRENDER SJ, DUNCAN MJ, KELSALL CJ, DOHERTY MK, WHITFIELD PD, MEGSON IL, MORRIS RE. (2016): Tuning the Nitric Oxide Release from CPO-27 MOFs, RSC Advances, 6, 14059-14067.
GEARY B, CASH P, YOUNG IS, WHITFIELD PD, DOHERTY MK. (2016): Comparing simplification strategies for the carp skeletal muscle proteome. Proteomes, 4,1, 10.
MCILROY GD, TAMMIREDDY SR, MASKREY BH, DOHERTY MK, WATSON DG, DELIBEGOVIĆ M, WHITFIELD PD, MODY N. (2016): Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue, Biochemical Pharmacology, 100, 86-97.
DOHERTY MK, OWEN MA, DAVIES SJ, YOUNG IS, WHITFIELD PD. (2013): Assessment of global proteome dynamics in carp: a model for investigating environmental stress, Journal of Proteome Research, 12, 5246-52.
Lipidomic Investigations of Macrophage Responses in Cardiovascular Disease, 2018 – 2022
Uncoupling the Mechanisms of Protein Degradation, 2016 – 2020
Investigating the Mechanisms of Inflammation, 2016 – 2020
Lipidomic and Proteomic Investigations of Commercial Bivalve Production in Scotland, 2016 – 2020
High performance analytical platforms for lipid and protein profiling, 2015 – 2020
Member of the Royal Society of Edinburgh Young Academy of Scotland
Member of the Royal Society of Chemistry
Policy development particularly in relation to PGR and ECR
Equal opportunities and diversity in academia
Two children age 3 and 7
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Health, Public Health
Physical sciences, Preparative and physical chemistry of polymersNanotechnology
Physical sciences
Biological and related sciences, Health, Cell Biology, Cellular signaling, Cancer biology, Cancer therapy