Short CV/Education and training

Present positions

  • Since 2019
    Deputy Head of the Dermatology and Venereology Division, Dept. Medicine Solna, KI

  • Since 2017
    Senior lecturer, research group leader; Karolinska Inst., Department of Medicine, Dermatology and Venereology Unit

  • Since 2016
    Board certified dermatologist, Karolinska University Hospital

Previous positions

  • 2016
    Adjunct senior lecturer and research group leader at KI, Department of Medicine, Dermatology and Venereology Unit

  • 2011 – 2016
    Associate professor, researcher at Karolinska Institutet (share of time 50%)

  • 2007 – 2011
    Assistant professor (forskarassistent), researcher (share of time 50%) Karolinska Institutet, Dept. of Medicine, Dermatology and Venereology Unit

  • 2007 – 2016
    Specialist training in dermatology and venereology, Karolinska Univ. Hospital (50%)

  • 2006
    Postdoctoral researcher, KI, Dept. of Medicine, Dermatology and Venereology Unit

  • 2005
    Postdoctoral researcher, Dept. of Dermatology, Heinrich-Heine Univ., Düsseldorf

Education

  • 2002 – 2005
    PhD in Immunology; Dept. of Dermatology, University of Szeged, Szeged, Hungary

  • 1996 – 2002
    MD, Semmelweis University, Faculty of Medicine, Budapest, Hungary, and University of Szeged, Faculty of Medicine, Szeged, Hungary

Selected publications

  • Srivastava A, Luo L, Lohcharoenkal W, Meisgen F, Pasquali L, Pivarcsi A, Sonkoly E. Cross-talk between IFN-γ and TWEAK through miR-149 amplifies skin inflammation in psoriasis. J Allergy Clin Immunol. 2021 Mar 8:S0091-6749(21)00361-4.

  • Srivastava A, Meisgen F, Pasquali L, Munkhammar S, Xia P, Ståhle M, Landén NX, Pivarcsi A, Sonkoly E. Next-Generation Sequencing Identifies the Keratinocyte-Specific miRNA Signature of Psoriasis. J Invest Dermatol. 2019 Dec;139(12):2547-2550.e12.

  • Pasquali L, Srivastava A, Meisgen F, Das Mahapatra K, Xia P, Xu Landén N, Pivarcsi A, Sonkoly E. The Keratinocyte Transcriptome in Psoriasis: Pathways Related to Immune Responses, Cell Cycle and Keratinization. Acta Derm Venereol. 2019 Feb 1;99(2):196-205.

    Srivastava A, Nikamo P, Lohcharoenkal W, Li D, Meisgen F, Xu Landén N, Ståhle M, Pivarcsi A, Sonkoly E. MicroRNA-146a suppresses IL-17-mediated skin inflammation and is genetically associated with psoriasis. J Allergy Clin Immunol. 2017 Feb;139(2):550-561.

  • Meisgen F, Xu Landén N; Wang A, Réthi B, Bouez C, Zuccolo M, Gueniche A, Ståhle M, Sonkoly E, Breton L, Pivarcsi A. MiR-146a negatively regulates TLR2-induced inflammatory responses in keratinocytes. J Invest Dermatol 2014;134(7):1931-40.

  • Meisgen F, Xu Landén N, Bouez C, Zuccolo M, Gueniche A, Ståhle M,Sonkoly E, Breton L, Pivarcsi A. Activation of Toll-like receptors alters the microRNA expression profile of keratinocytes. Exp Dermatol. 2014; 23(4):281-3.

  • Pivarcsi A, Meisgen F, Xu N, Ståhle M, Sonkoly E. Changes in the level of serum microRNAs in psoriasis patients after anti-tumor necrosis factor-α therapy. Br J Dermatol 2013; 169(3):563-70.

  • Xu N., Meisgen F., Butler L.M., Han G., Wang X.J., Söderberg-Nauclér C., Ståhle M., Pivarcsi A., Sonkoly E. MicroRNA-31 is overexpressed in psoriasis and modulates inflammatory cytokine and chemokine production in keratinocytes via targeting STK40. J Immunol, 2012; 190(2):678-88.

  • Meisgen F, Xu N, Wei T, Janson PC, Obad S, Broom O, Nagy N, Kauppinen S, Kemény L, Ståhle M, Pivarcsi A, Sonkoly E. MiR-21 is up-regulated in psoriasis and suppresses T cell apoptosis. Exp Dermatol. 2012;21(4):312-4.

  • The expression of microRNA-203 during human skin morphogenesis. Wei T, Orfanidis K, XuN, Janson P, Ståhle M, Pivarcsi A and Sonkoly E. Dermatol. 2010 (9):854-6.

  • Sonkoly E, Janson P, Majuri M, Savinko T, Fyhrquist N, Xu N, Wei T, Stenvang J, Kauppinen S, Alenius H, Lauerma A, Homey B, Winqvist O, Ståhle M, Pivarcsi A. MiR-155 is overexpressed in atopic dermatitis and modulates T cell proliferative responses by targeting CTLA-4. J All Clin Immunol. 2010; 126(3):581-9.e1-20.



Complete list of publications

Selected projects

  • Investigation of non-coding RNAs in psoriasis

  • Psoriasis is the most common chronic inflammatory skin disease in adults, affecting 2-3% of the population. Psoriasis has a significant impact on patients’ quality of lfe and is now considered as a sytemic disease with significant comorbidities. Our group’s main scientific focus is to explore the role of non-coding regulatory RNAs, including miRNAs and long non-coding RNAs, in psoriasis, to understand their roles in the disease and to explore the possibilities of non-coding RNA modulation for topical and systemic treatment. Another main goal for our research is the identification of miRNA-based biomarkers for prediction of treatment response and diagnosis of comorbidities.

Membership in scientific bodies/juries

  • Board member of the ESDR (European Society for Dermatological Research), since 2019

  • Chair of the Scientific and Educational advisory board at the Unit of Dermatology, Karolinska Univ. Hospital (since 2018, member since 2013)

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