Dr. Polly Leilei Chen

• Since 2015
  President Assistant Professor, National University of Singapore (NUS)
  
  

• Since 2014
  Assistant Professor, Department of Anatomy, NUS
  
  

• Since 2014
  Principal Investigator, Cancer Science Institute of Singapore (CSI), NUS
  
  

• 2013 – 2014
  Research Assistant Professor and CSI special fellow, CSI, NUS
  
  

• 2012
  Senior Research Scientist, CSI,NUS
  
  

• 2005 – 2006
  Clinician, Department of Obstetrics and Gynaecology, Nanjing Drum Tower Hospital, China
  
  

• 2002 – 2005
  Research Associate, Research Centre of Nanjing Drum Tower Hospital, China
  
  

• Tang SJ, Shen H, An O, Hong HQ, Li J, Song Y, Han J, Tay DJ, Ng VHE, Molias FB, Leong KW, Pitcheshwar P, Yang H, Chen L. Cis- and trans-regulation of pre-mRNA splicing by RNA editing enzymes: influencing cancer development. Nature Communications, 11, Article number: 799 (2020). Impact factor: 11.88

• Hong H, An Ő, Chan TH, Ng VHE, Kwok HS, Lin JS, Qi L, Han J, Tay DJ, Tang SJ, Yang H, Song YY, Molias FB, Tenen DG, Chen L. Bidirectional regulation of adenosine-to-inosine (A-to-I) RNA editing by DEAH box helicase 9 (DHX9) in cancer. Nucleic Acids Res, 2018 May 18. Impact factor: 11.56

• Qi L, Song Y, Chan TH, Yang H, Lin CH, Tay ST, Hong H, Tang SJ, Tan KT, Huang XX, Lin JS, Ng VHE, Maury JJP, Tenen DG, Chen L. An RNA editing/dsRNA binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer. Nucleic Acids Res. 2017, 45(18): 10436-10451. Impact factor: 11.56

• Chan TH, Qamra A, Tan KT, Guo J, Yang H, Qi L, Lin JS, Ng VHE, Song Y, Hong H, Tay ST, Liu Y, Lee J, Rha SY, Feng Z, So JBY, The BT, Yeoh KG, Rozen S, Tenen DG, Tan P, Chen L. ADAR-mediated RNA editing predicts progression and prognosis of Gastric Cancer. Gastroenterology. 2016,151(4):637-650. Impact factor: 20.77

• Chan TH, Lin CH, Qi L, Fei J, Li Y, Yong KJ, Liu M, Song Y, Chow RK, Ng VH, Yuan YF, Tenen DG, Guan XY, Chen L*. A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma. Gut. 2014, 63(5):832-43. Impact factor: 17.02

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