Dr. Valérie Castellani

Education

• 1989
  Master of Molecular Biology and Genetics, University of Bordeaux, France
  
  

• 1990
  Master of Management and global business, Institut d’administration des Entreprises (IAE), Lyon, France
  
  

• 1998
  PhD of Biology, Neuroscience, University Claude-Bernard of Lyon, France
  
  

• 2006
  HDR, University Claude-Bernard of Lyon, France
  
  

Previous positions

• 1991 – 1992
  ORSTOM, CIBA-GEIGY, Yaoundé, Cameroun. One-year contract at the phytosanitary station to study a pathology of cocoa cultures.
  
  

• 1992 – 1993
  COMITE D’EXPANSION AQUITAINE, Bordeaux, France. One year-contract to develop the relationships between academic scientists and industry in the field of the Biotechnology.
  
  

• 1994 – 1998
  PhD student, INSERM "Cerveau et Vision", University of Lyon, France, Supervision. Dr J. Bolz
  
  

• 1998 – 2000
  Post-doctoral Fellow IBDML, University of Marseille-Luminy, Marseille, France
  
  

• 2000 – 2004
  Research Associate CR2, CNRS
  
  

• 2004 – 2009
  Research Associate CR1, CNRS
  
  

• 2009 – 2014
  Research Director DR2, CNRS
  
  

Current position

• Since 2003
  Group Leader
  
  

• Since 2014
  Research Director DR1, CNRS Neuromyogene Institute, UMR5310 CNRS/U1217 Inserm, University of Lyon, Department of Biology, Lyon, France
  
  

• Arbeille E*, Reynaud F*, Sanyas I, Bozon M, Kindbeiter K, Causeret F, Pierani A, Falk J, Moret F*, Castellani V* (2015) Cerebrospinal fluid-derived Semaphorin3B orients neuroepithelial cell divisions in the apicobasal axis. Nat Commun. 27;6:6366. doi: 10.1038/ncomms7366.

• Delloye-Bourgeois C, Jacquier A, Charoy C, Reynaud F, Nawabi H, Thoinet K, Kindbeiter K, Yoshida Y, Zagar Y, Kong Y, Jones YE, Falk J, Chédotal A, Castellani V (2015) PlexinA1 is a new Slit receptor and mediates axon guidance function of Slit C-terminal fragments. Nat Neurosci. 2014

• Charoy C*, Nawabi H*, Reynaud F, Derrington E, Bozon M, Wright K, Falk J, Helmbacher F, Kindbeiter K, Castellani V (2012) gdnf activates midline repulsion by Semaphorin3B via NCAM during commissural axon guidance. Neuron, 75(6):1051-66.

• Sanyas I, Bozon M, Moret F*, Castellani V* (2012) Motoneuronal Sema3C is essential for setting stereotyped motor tract positioning in limb-derived chemotropic Semaphorins. Development, 139(19):3633-43.

• Nawabi H*, Briançon-Marjollet A*, Clark C, Sanyas I, Takamatsu H, Okuno T, Kumanogoh A, Bozon M, Takeshima K, Yoshida Y, Moret F, Abouzid K, Castellani V (2010) A midline switch of receptor processing regulates commissural axon guidance in vertebrates. Genes&Dev, 24(4):396-41.

• Bechara A, H. Nawabi, F. Moret, A. Yaron, E. Weaver, M. Bozon, K. Abouzid, JL Guan, M. Tessier-Lavigne, V. Lemmon, V. Castellani (2008) FAK-MAPK-dependant adhesion disassembly downstream of L1 contributes to Semaphorin3A-induced growth cone collapse. Embo J;27(11):1549-62.

• Falk J*, A. Bechara*, R. Fiore, C. Hoyo-Becerra, M. Bozon, H. Zhou, G. Rougon, M. Grumet, A. W. Püschel, J.R. Sanes, V. Castellani (2005) Dual functional activity of Semaphorin3B is required for positioning the anterior commissure. Neuron: 48,63-75.

• Castellani V, E. De Angelis, S. Kenwrick, G. Rougon (2002) Cis and trans interactions of L1 with Neuropilin-1 control axonal responses to Semaphorin 3A, EMBO J,21 :6348-57.

• Castellani V, A Chédotal, M. Schachner, C. Faivre-sarrailh, and G. Rougon (2000) Analysis of L1-deficient mouse phenotype reveals a cross-talk between Sema3A and L1 signaling pathways in axonal guidance, Neuron 27(2):237-49 (see comments Neuron 27(2):191).

• Castellani V and J. Bolz (1997) Membrane-associated molecules regulate the formation of layer-specific cortical circuits, Proc.Natl.Acad.Sci 94(13):7030-7035.

Ongoing grants

• FP7 ERC Consolidator YODA 2010, 2012 – 2017

• Labex (Laboratory of Excellence) DevWeCAN operated by the ANR

• Labex (Laboratory of Excellence) CORTEX operated by the ANR

• INCA National Institute of Cancer

• CNRS Pre-maturation program

Organization of scientific meetings/participation to international conferences

• Co-organizer of an annual one-day conference of the French Association "Development of neuronal networks". 80 participants, 2010 – 2014

• Co-organizer of an Embo Workshop "Mechanisms of action of Semaphorins" Cargèse, France, 150 participants, Les Vaulx de Cernay, France, 150 participants, 2008

• Co-organizer of an Embo Workshop "Semaphorin function and mechanism of action: a Decade of semaphorin research" Cargèse, France, 150 participants, 2003

• 19 Conferences in national and international meetings since 2003

Institutional responsibilities

• Member of the Scientific committee of the FRM (Fondation pour la Recherche Médicale), 2014

• Member of the Scientific committee of the FRC (French foundation for brain research, 2010 – 2014

• Member of the Administration committee of the French Society of Neuroscience, 2010 – 2014

• Member of the Scientific council of the Doctoral School BMIC of the University of Lyon, 2011 – 2015

Commissions of trust

• Vice-President of the ANR committee "Neurosciences Mol Cell Dev", 2015

• AERES Review Panel Member Institut Jacque Monod, Paris, France, 2014

• AERES Review Panel Member Institut de la Vision, Paris, France, 2014

• Scientific expert for ERC starting grant evaluation, 2012 – 2013

• Scientific expert for national founding agencies and charities, and International founding agencies in Austria, Ireland, Israel, Belgium, the Netherlands, and UK, since 2003

• Reviewer for scientific journals, since 2003

Memberships of scientific societies

• Member of the French Society of Neuroscience, 2002

• Member of the American Society of Neuroscience, 2002

• Member of the French Society of Development, 2011

• President of the French club "Development of neuronal networks", 2010 – 2014

• French TV LCI: invited to a TV program by Dr Alain

• Ducardonnet (2012)

• Radio interview (2015)

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