Prof. Avan Aihie Sayer
Health, Academic Medicine
Biological and related sciences, Health
Neurobiology, development of the nervous system, formation of neuronal connectivity
Characterization of gene pathways controlling early steps of the formation of the nervous system
Characterization of developmental programs reactivated during tumorigenesis
Grant ANR, 3 years PI, 2010 – 2013
ERC Consolidator fellow, call 2010
Grant FRM Label label, 3 years PI, 2009 – 2011
AFM grant, 3years PI, 2007 – 2008
ANR grant, 3years PI, 2006 – 2009
Wings for Life Spinal Cord Research Foundation 2 years, 2006
FRM New Team grant for equipment PI and ARC grant, 2003 – 2004
ATIP CNRS to start independent group, 3 years, extension ATIP+ 2 years, 2003
Labex (Laboratory of Excellence) team
Foundation for Medical Research (FRM) call Team Label
ATIP CNRS fellow 2003
English, French
Arbeille E*, Reynaud F*, Sanyas I, Bozon M, Kindbeiter K, Causeret F, Pierani A, Falk J, Moret F*, Castellani V* (2015) Cerebrospinal fluid-derived Semaphorin3B orients neuroepithelial cell divisions in the apicobasal axis. Nat Commun. 27;6:6366. doi: 10.1038/ncomms7366.
Delloye-Bourgeois C, Jacquier A, Charoy C, Reynaud F, Nawabi H, Thoinet K, Kindbeiter K, Yoshida Y, Zagar Y, Kong Y, Jones YE, Falk J, Chédotal A, Castellani V (2015) PlexinA1 is a new Slit receptor and mediates axon guidance function of Slit C-terminal fragments. Nat Neurosci. 2014
Charoy C*, Nawabi H*, Reynaud F, Derrington E, Bozon M, Wright K, Falk J, Helmbacher F, Kindbeiter K, Castellani V (2012) gdnf activates midline repulsion by Semaphorin3B via NCAM during commissural axon guidance. Neuron, 75(6):1051-66.
Sanyas I, Bozon M, Moret F*, Castellani V* (2012) Motoneuronal Sema3C is essential for setting stereotyped motor tract positioning in limb-derived chemotropic Semaphorins. Development, 139(19):3633-43.
Nawabi H*, Briançon-Marjollet A*, Clark C, Sanyas I, Takamatsu H, Okuno T, Kumanogoh A, Bozon M, Takeshima K, Yoshida Y, Moret F, Abouzid K, Castellani V (2010) A midline switch of receptor processing regulates commissural axon guidance in vertebrates. Genes&Dev, 24(4):396-41.
Bechara A, H. Nawabi, F. Moret, A. Yaron, E. Weaver, M. Bozon, K. Abouzid, JL Guan, M. Tessier-Lavigne, V. Lemmon, V. Castellani (2008) FAK-MAPK-dependant adhesion disassembly downstream of L1 contributes to Semaphorin3A-induced growth cone collapse. Embo J;27(11):1549-62.
Falk J*, A. Bechara*, R. Fiore, C. Hoyo-Becerra, M. Bozon, H. Zhou, G. Rougon, M. Grumet, A. W. Püschel, J.R. Sanes, V. Castellani (2005) Dual functional activity of Semaphorin3B is required for positioning the anterior commissure. Neuron: 48,63-75.
Castellani V, E. De Angelis, S. Kenwrick, G. Rougon (2002) Cis and trans interactions of L1 with Neuropilin-1 control axonal responses to Semaphorin 3A, EMBO J,21 :6348-57.
Castellani V, A Chédotal, M. Schachner, C. Faivre-sarrailh, and G. Rougon (2000) Analysis of L1-deficient mouse phenotype reveals a cross-talk between Sema3A and L1 signaling pathways in axonal guidance, Neuron 27(2):237-49 (see comments Neuron 27(2):191).
Castellani V and J. Bolz (1997) Membrane-associated molecules regulate the formation of layer-specific cortical circuits, Proc.Natl.Acad.Sci 94(13):7030-7035.
FP7 ERC Consolidator YODA 2010, 2012 – 2017
Labex (Laboratory of Excellence) DevWeCAN operated by the ANR
Labex (Laboratory of Excellence) CORTEX operated by the ANR
INCA National Institute of Cancer
CNRS Pre-maturation program
Co-organizer of an annual one-day conference of the French Association "Development of neuronal networks". 80 participants, 2010 – 2014
Co-organizer of an Embo Workshop "Mechanisms of action of Semaphorins" Cargèse, France, 150 participants, Les Vaulx de Cernay, France, 150 participants, 2008
Co-organizer of an Embo Workshop "Semaphorin function and mechanism of action: a Decade of semaphorin research" Cargèse, France, 150 participants, 2003
19 Conferences in national and international meetings since 2003
Member of the Scientific committee of the FRM (Fondation pour la Recherche Médicale), 2014
Member of the Scientific committee of the FRC (French foundation for brain research, 2010 – 2014
Member of the Administration committee of the French Society of Neuroscience, 2010 – 2014
Member of the Scientific council of the Doctoral School BMIC of the University of Lyon, 2011 – 2015
Vice-President of the ANR committee "Neurosciences Mol Cell Dev", 2015
AERES Review Panel Member Institut Jacque Monod, Paris, France, 2014
AERES Review Panel Member Institut de la Vision, Paris, France, 2014
Scientific expert for ERC starting grant evaluation, 2012 – 2013
Scientific expert for national founding agencies and charities, and International founding agencies in Austria, Ireland, Israel, Belgium, the Netherlands, and UK, since 2003
Reviewer for scientific journals, since 2003
Member of the French Society of Neuroscience, 2002
Member of the American Society of Neuroscience, 2002
Member of the French Society of Development, 2011
President of the French club "Development of neuronal networks", 2010 – 2014
French TV LCI: invited to a TV program by Dr Alain
Ducardonnet (2012)
Radio interview (2015)
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Health, Academic Medicine
Biological and related sciences, Cell Biology, Molecular Biology, Biochemistry, Microscopy
Biological and related sciences, Health, Cell Biology, Cellular signaling, Cancer biology, Cancer therapy
Biological and related sciences, Evolution, genomics, bioinformatics