Short CV/Education and training

  • Since 2017
    Junior professor for structure and Function of metalloproteins at Heinrich Heine University Duesseldorf

  • 2015 – 2017
    Leader of a Liebig research group at Heinrich Heine University Duesseldorf

  • 2014 – 2015
    Leader of an independent research group at Heinrich Heine University Duesseldorf

  • 2012 – 2014
    Postdoctoral qualification at Northwestern University in Chicago

  • 2009 – 2012
    Doctorate in Biochemistry at Technical University Munich

  • 2003 – 2008
    Chemistry studies at Technical University Munich

Selected publications

  • Charge-Disproportionation Symmetry Breaking Creates a Heterodimeric Myoglobin Complex with Enhanced Affinity and Rapid Intracomplex Electron Transfer, E. N. Trana, J. M. Nocek, J. V. Woude, I. Span, S. M Smith, A. C. Rosenzweig, B. M. Hoffman, J. Am. Chem. Soc. 2016, 138 (38), 12615–12628.

  • A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism, S. G. Kathman, I. Span, A. T. Smith, Z. Xu, J. Zhan, A. C. Rosenzweig, A. V. Statsyuk, J. Am. Chem. Soc. 2015, 137 (39), 12442-12445.

  • Insights into the Binding of Pyridines to the Iron-Sulfur Enzyme IspH, I. Span, K. Wang, W. Eisenreich, A. Bacher, Y. Zhang, E. Oldfield, M. Groll, J. Am. Chem. Soc. 2014, 136 (22), 7926-7932.

  • Structures of fluoro, amino, and thiol inhibitors bound to the [Fe4S4] protein IspH, I. Span, K. Wang, W. Wang, J. Jauch, W. Eisenreich, A. Bacher, E. Oldfield, M. Groll, Angew. Chem. 2013, 125 (7), 2172-2175.

  • Discovery of acetylene hydratase activity of the iron-sulphur protein IspH,

    I. Span, K. Wang, W. Wang, Y. Zhang, A. Bacher, W. Eisenreich, K. Li, C. Schulz, E. Oldfield, M. Groll, Nat. Commun. 2012, 3, 1042.

  • Are free radicals involved in IspH catalysis? An EPR and crystallographic investigation, W. Wang, K. Wang, I. Span, J. Jauch, A. Bacher, M. Groll, E. Oldfield, J. Am. Chem. Soc. 2012, 134 (27), 11225-11234.

  • Crystal Structures of Mutant IspH Proteins Reveal a Rotation of the Substrate’s Hydroxymethyl Group during Catalysis, I. Span, T. Gräwert, A. Bacher, W. Eisenreich, M. Groll, J. Mol. Biol. 2012, 416 (1), 1-9.

  • Probing the reaction mechanism of IspH protein by x-ray structure analysis, T. Gräwert, I. Span, W. Eisenreich, F. Rohdich, J. Eppinger, A. Bacher, M. Groll, Proc. Natl. Acad. Sci. U. S. A. 2010, 107 (3), 1077-1081.

  • Structure of Active IspH Enzyme from Escherichia coli Provides Mechanistic Insights into Substrate Reduction, T. Gräwert, F. Rohdich, I. Span, A. Bacher, W. Eisenreich, J. Eppinger, M. Groll, Angew. Chem. 2009, 121, 5867-5870.

Complete list of publications

Selected projects

  • Artificial cobalt-sulfur proteins

  • Catalytically active DNA sequences

Membership in scientific bodies/juries

  • Female Research EQuality (FREQ) network

  • Gesellschaft Deutscher Chemiker e.V. (GDCh)

  • Gesellschaft für Biochemie und Molekularbiologie e.V. (GBM)

  • Bund der Freunde der Technischen Universität München e.V.


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