Short CV/Education and training

Education/degrees

  • 1977
    High school degree, latin-greek-philosophy, Como, Italy

  • 1981
    Bachelor of Science in Pharmacology & Toxicology, Biochemistry and Vegetal Physiology, University of Lausanne.

  • 1986
    Doctor of Philosophy in Toxicology, mention "summa cum laude" University of Lausanne, Switzerland.

  • 1998
    Privat-docent

Professional experience:

  • 1987
    Postdoctoral fellow Institute of Pharmacology & Toxicology, University of Lausanne (Prof. J. Diezi)

  • 1988
    Postdoctoral fellow, Occupational Health Sciences Institute, University of Lausanne, Switzerland (Prof. H.Savolainen & Prof.M. Guillemin)

  • 1988 – 1991
    Postdoctoral fellow at the Swiss Institute on Experimental Cancer Research, Epalinges, Switzerland (Dr. P. Cerutti)

  • 1991 – 1993
    Postdoctoral fellow at the National Cancer Institute, Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, USA (Dr. C.C. Harris)

  • 1993 – 1999
    Lecturer, Institute of Pharmacology & Toxicology, University of Lausanne (Prof. J. Diezi)

  • 1999 – 2006
    Substitute Assistant professor, Institute of Pharmacology & Toxicology, University of Lausanne

  • 2006
    Invited scientist DKFZ, Heidelberg

  • since 2007
    group leader, Laboratory of Molecular Oncology, Dept Thoracic Surgery, Lungen- und Thoraxonkologie Zentrum of Zurich University Hospital

Selected publications

  • Okonska A and Felley-Bosco E, “BAP1 missense mutations in cancer: friend or foe?” Trends in Cancer 2019. doi: 10.1016/j.trecan.2019.09.006, in press

  • Okonska A, Bühler S, Rao V, Ronner M, Blijlevens M, van der Meulen-Muileman IH, de Menezes RX, Wipplinger M, Oehl K, Smit EF, Weder W, Stahel RA, Penengo L, van Beusechem VW, Felley-Bosco E. “Functional genomic screen in mesothelioma reveals that loss of function of BRCA1-associated-protein-1 induces chemoresistance to ribonucleotide reductase inhibition” Mol Cancer Ther. 2019 Oct 16. pii: molcanther.0356.2019. doi: 10.1158/1535-7163.MCT-19-0356. [Epub ahead of print] PMID: 31619462

  • Kresoja-Rakic J, Szpechcinski A, Kirschner MB, Ronner M, Minatel B, Martinez VD, Lam WL, Weder W, Stahel R, Früh M, Cerciello F, Felley-Bosco E. “miR-625-3p and lncRNA GAS5 in Liquid Biopsies for Predicting the Outcome of Malignant Pleural Mesothelioma Patients Treated with Neo-Adjuvant Chemotherapy and Surgery” Noncoding RNA. 2019 Jun 17;5(2). pii: E41. doi: 10.3390/ncrna5020041. PMID: 31212997

  • Kresoja-Rakic J, Felley-Bosco E. Desthiobiotin-Streptavidin-Affinity Mediated Purification of RNA-Interacting Proteins in Mesothelioma Cells. J Vis Exp. 2018 Apr 25;(134). doi: 10.3791/57516. PMID: 29757292

  • Felley-Bosco E, Rehrauer H. Non-Coding Transcript Heterogeneity in Mesothelioma: Insights from Asbestos-Exposed Mice. Int J Mol Sci. 2018 Apr 11;19(4). pii: E1163. doi: 10.3390/ijms19041163. PMID: 29641489

  • Oehl K, Kresoja-Rakic J, Opitz I, Vrugt B, Weder W, Stahel R, Wild P, Felley-Bosco E. Live-Cell Mesothelioma Biobank to Explore Mechanisms of Tumor Progression. Front Oncol. 2018 Feb 23;8:40. https://www.frontiersin.org/articles/10.3389/fonc.2018.00040/full . PMID: 29527515

  • Hubert Rehrauer, Licun Wu, Walter Blum, Lazslo Pecze, Thomas Henzi, Véronique Serre-Beinier, Catherine Aquino, Bart Vrugt, Marc de Perrot, Beat Schwaller, Emanuela Felley-Bosco. How asbestos drives the tissue towards tumors: YAP activation, macrophage and mesothelial precursor recruitment, RNA editing and somatic mutations. Oncogene, 37(20):2645-2659. http://www.nature.com/articles/s41388-018-0153-z

  • Kresoja-Rakic, J.; Sulemani, M.; Kirschner, M.B.; Ronner, M.; Reid, G.; Kao, S.; Schwaller, B.; Weder, W.; Stahel, R.A.; Felley-Bosco, E. Posttranscriptional regulation controls calretinin expression in malignant pleural mesothelioma. Frontiers in Genetics 29 May 2017 | https://doi.org/10.3389/fgene.2017.00070

  • Parrotta R, Okonska A, Ronner M, Weder W, Stahel R, Penengo L, Felley-Bosco E. A Novel BRCA1-Associated Protein-1 Isoform Affects Response of Mesothelioma Cellsto Drugs Impairing BRCA1-Mediated DNA Repair. J Thorac Oncol. 2017 Apr 4. pii:S1556-0864(17)30274-5. doi: 10.1016/j.jtho.2017.03.023. PubMed PMID: 28389374.



Complete list of publications

Selected projects

  • RNA editing in mesothelioma

  • From asbestos-exposure to cancer: a systemic approach to detect loss of homeostatic control in the mesothelial environment

  • Preclinical Malignant Pleural Mesothelioma Models To Accelerate Clinical Research On Targeted Therapies

Membership in scientific bodies/juries

  • Swiss Society of Pharmacology and Toxicology , IASLC

Media coverage

  • http://ecancer.org/video/1931/mesothelioma-and-the-tumour-suppressor-gene--nf2.php

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