Short CV/Education and training

  • 1989 – 1995
    Academic studies at the University Hamburg

  • 1994 – 1995
    Graduated as Diplom Biologin. Topic: "Einfluss des "XP-Motivs" auf die Antigenpräsentation von I-Ad assoziierten Ovalbumin-Peptiden" (very good: 1,0)

  • 1995 – 1999
    Graduated as "Doktorin der Naturwissenschaften" (Dr. rer. nat.) at the University Hamburg, Faculty of Biology. Topic: "Charakterisierung der Antigen-spezifischen und Antigen-unabhängigen Aktivierung von murinen CD8+ T-Zellen durch die Hitzeschock-Proteine HSP70 und GP96 in vivo und in vitro" (very good: 1.1)

  • 1999 – 2001
    Junior Postdoc at the Department of Immunology, Bernhard Nocht Institute for Tropical Medicine. Major Topic: Immune stimulatory functions of autologous HSP60

  • 2002
    Parental leave

  • 2002 – 2007
    Senior Postdoc at the Department of Immunology, Bernhard Nocht Institute for Tropical Medicine. Major Topic: Characterization of the immunological function of the transmembrane protein CD83

  • 2007
    Graduated as "Fachimmunologin" by the German Society for Immunology

  • Since 2007
    Group leader of the laboratory "helminth immunology" at the Bernhard Nocht Institute for Tropical Medicine. Major Topic: Nematode infections in mice: immune response and immune modulation

  • 2010
    Habilitation at the University Hamburg. Topic: "Die Regulation von Lymphozyten Reifung, Aktivierung und Homöostase durch das Transmembranprotein CD83". (Award of the Venia Legendi at the University Hamburg Faculty of Mathematics, Informatics and Natural Sciences for the subject Zoology with Focus on Immunology)

Selected publications

  • Hartmann, W., Schramm, C. and Breloer, M., Litomosoides sigmodontis induces TGF-beta receptor responsive, IL-10-producing T cells that suppress bystander T-cell proliferation in mice. 2015 European Journal of Immunology 45: 2568-2581

  • Breloer, M., W. Hartmann, B. Blankenhaus, M. L. Eschbach, K. Pfeffer, and T. Jacobs. 2015. Cutting Edge: The BTLA-HVEM Regulatory Pathway Interferes with Protective Immunity to Intestinal Helminth Infection. Journal of Immunology 194: 1413-1416

  • Ulges, A., M. Klein, S. Reuter, B. Gerlitzki, M. Hoffmann, N. Grebe, V. Staudt, N. Stergiou, T. Bohn, T. J. Bruhl, S. Muth, H. Yurugi, K. Rajalingam, I. Bellinghausen, A. Tuettenberg, S. Hahn, S. Reissig, I. Haben, F. Zipp, A. Waisman, H. C. Probst, A. Beilhack, T. Buchou, O. Filhol-Cochet, B. Boldyreff, M. Breloer, H. Jonuleit, H. Schild, E. Schmitt, and T. Bopp. 2015. Protein kinase CK2 enables regulatory T cells to suppress excessive T2 responses in vivo. Nature immunology 16: 267-275

  • Blankenhaus, B., M. Reitz, Y. Brenz, M. L. Eschbach, W. Hartmann, I. Haben, T. Sparwasser, J. Huehn, A. Kuhl, T. B. Feyerabend, H. R. Rodewald, and M. Breloer. 2014. Foxp3+ regulatory T cells delay expulsion of intestinal nematodes by suppression of IL-9-driven mast cell activation in BALB/c but not in C57BL/6 mice. PLoS pathogens 10: e1003913.

  • Haben, I., W. Hartmann, and M. Breloer. 2014. Nematode-induced interference with vaccination efficacy targets follicular T helper cell induction and is preserved after termination of infection. PLoS neglected tropical diseases 8: e3170

  • Haben, I., W. Hartmann, S. Specht, A. Hoerauf, A. Roers, W. Muller, and M. Breloer. 2013. T-cell-derived, but not B-cell-derived, IL-10 suppresses antigen-specific T-cell responses in Litomosoides sigmodontis-infected mice. European Journal of Immunology 43: 1799-1805.

  • Kolbaum, J., S. Tartz, W. Hartmann, S. Helm, A. Nagel, V. Heussler, P. Sebo, B. Fleischer, T. Jacobs, and M. Breloer. 2012. Nematode-induced interference with the anti-Plasmodium CD8+ T-cell response can be overcome by optimizing antigen administration. European Journal of Immunology 42: 890-900.

  • Hartmann, W., I. Haben, B. Fleischer, and M. Breloer. 2011. Pathogenic nematodes suppress humoral responses to third-party antigens in vivo by IL-10-mediated interference with Th cell function. Journal of Immunology 187: 4088-4099

  • Blankenhaus, B., U. Klemm, M. L. Eschbach, T. Sparwasser, J. Huehn, A. A. Kuhl, C. Loddenkemper, T. Jacobs, and M. Breloer. 2011. Strongyloides ratti infection induces expansion of Foxp3+ regulatory T cells that interfere with immune response and parasite clearance in BALB/c mice. Journal of Immunology 186: 4295-4305.

  • Kretschmer, B., K. Luthje, S. Schneider, B. Fleischer, and M. Breloer. 2009. Engagement of CD83 on B cells modulates B cell function in vivo. Journal of Immunology 182: 2827-2834.

Complete list of publications

Selected projects

  • One third of the world population is infected with parasitic worms. These parasites delay or avoid elimination by dampening the immune responses of their hosts. Our group uses murine models of worm infections to investigate i) the nature of a protective anti-worm immune response, ii) the mechanisms of worm-induced immune modulation, and iii) the impact of concurrent worm infection on other immune responses in situations of co-infection or vaccination

Additional qualifications

  • 04.2007: Graduated as "Fachimmunologin" by the German Society for Immunology


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