Short CV/Education and training

Education

  • 1985 – 1989
    Master's Degree, University of Pavia, Italy, Faculty: Biology. Grade: 110/110 summa cum laude

  • 1989 – 1993
    Ph.D. Institute of Genetics and Microbiology, University of Pavia, Italy

  • 1995
    Licence (Biologist), University of Pavia, Italy

  • 2011
    Habilitation, Molecular Pathology, Faculty of Medicine, Technical University Munich

Scientific career

  • 1993 – 1995
    Post-doctoral fellow, Department of Microbiology and Molecular Genetics, University of California at Irvine, Irvine, CA, USA

  • 1995 – 1998
    Post-doctoral fellow, Department of Genetics and Microbiology, University of Pavia

  • 1998 – 2000
    Post-doctoral fellow, Human Cancer Genetics Division, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio

  • 2000 – 2002
    Research Scientist, Human Cancer Genetics Division, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio

  • 2001 – 2011
    Adjunct Assistant Professor, Department of Molecular Virology, Immunology and Medical Genetics, College of Medicine, Ohio State University, Columbus, Ohio

  • 2002 – 2007
    Senior Scientist, Institut für Pathologie, Helmholtz Zentrum München

  • Since 2007
    Head of the Neuroendocrine Cell Transformation and Dysfunction Group, Institut für Pathologie, Helmholtz Zentrum München

Selected publications

  • Pellegata NS, Antoniono RJ, Redpath JL and Stanbridge EJ. (1996) DNA damage and p53-mediated cell cycle arrest: a reevaluation. Proc. Natl. Acad. Sci. USA 93, 15209-15214.

  • Pellegata NS, Dieguez-Lucena JL, Joensuu T, Lau S, Montgomery KT, Krahe R, Kivela T, Kucherlapati R, Forsius H and de la Chapelle A. (2000) Mutation in KERA, encoding keratocan, cause cornea plana. Nature Genet. 25, 91-95.

  • Yoon H, Liyanarachchi S, Wright FA, Davuluri R, Lockman JC, De La Chapelle A, Pellegata NS. (2002) Gene expression profiling of isogenic cells with different TP53 gene dosage reveals numerous genes that are affected by TP53 dosage and identifies CSPG2 as a direct target of p53. Proc. Natl. Acad. Sci. U S A 99, 15632-7.

  • Pellegata NS, Quintanilla-Martinez L, Siggelkow H, Samson E, Bink K, Höfler H, Fend F, Graw J, Atkinson MJ. (2006) Germline mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and man. Proc Natl Acad Sci USA 2006, 103:15558-63.

  • Molatore S, Liyanarachchi S, Irmler M, Perren A, Mannelli M, Ercolino T, Beuschlein F, Jarzab B, Wloch J, Ziaja J, Zoubaa S, Neff F, Beckers J, Höfler H, Atkinson MJ, Pellegata N.S. (2010) MENX-associated pheochromocytoma shares gene expression patterns with human pheochromocytoma. Proc Natl Acad Sci USA 107:18493-8.

  • Lee M, Marinoni I, Irmler I, Psaras T, Honegger JB, Beschorner R, Anastasov N, Beckers J, Theodoropoulou M, Roncaroli F, Pellegata NS. (2013) Transcriptome analysis of MENX-associated rat pituitary adenomas identifies novel molecular mechanisms involved in the pathogenesis of human pituitary gonadotroph adenomas. Acta Neuropathol, 126:137-50.

  • Lee M, Wiedemann T, Gross C, Roncaroli F, Braren R, Pellegata NS. (2015) Targeting PI3K/mTOR signaling displays potent antitumor efficacy against nonfunctioning pituitary adenomas. Clinical Cancer Research, 21:3204-3215.

  • Wiedemann T, Bielohuby M, Müller TD, Bidlingmaier M, Pellegata NS. (2016) Obesity in MENX rats is accompanied by high circulating levels of ghrelin and improved insulin sensitivity. Diabetes, 65:406-20.


Membership in scientific bodies/juries

  • Union for International Cancer Control (UICC), since 1998

  • American Association for Cancer Research (AACR), since 2000

  • European Neuroendocrine Tumors Society (ENETS), since 2006

  • European Society of Endocrinology (ESE), since 2012

  • European Network for the Study of Adrenal Tumours (ENS@T), since 2013

  • Appointed to the committee for the external evaluation of the KFO 252 "Microenvironment of the Adrenal in Health and Disease" by the Deutsche Forschungsgemeinschaft (DFG) (in 2011 and 2014)

  • Member of the Regional Scientific Committee for the "IWMEN 2012" international workshop on multiple endocrine neoplasia (2012)

Professional activities

  • Ad Hoc Scientific reviewer: Cancer Research; PlosOne; Cancer Letters; Endocrine-related Cancers; Journal of Clinical Endocrinology and Metabolism; Molecular and Cellular Endocrinology; European Journal of Endocrinology

  • Ad Hoc International Grant Reviewer: Agence Nationale de la Recherche (ANR), France; Association for International Cancer Research (AICR), United Kingdom; Institut National de la Santé et de la Recherche Médicale (Inserm), France

Soft Skills/Other activities and achievements

Other activities and achievements/family

  • Married, 2 children


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